Lipid based nanovectors containing ruthenium complexes: a potential route in cancer therapy

Abstract

Ruthenium complexes offer new perspectives in cancer therapy; towards this aim we have synthesized a new amphiphilic unimer able to coordinate ruthenium complexes and to form liposomes.

RuIII Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

“…In 2012, almost simultaneously, two different research groups -Walsby et al [87] and Paduano et al [88][89][90] -revisited a pyridine analogue of NAMI-A, called NAMI-Pyr by the first group and AziRu by the second. Its structure had been described previously by Attia et al in 1993.…”

“…This leads to partial hydrolysis of the complexes and eventually to formation of polyoxo species. [88][89][90][105][106][107][108][109] [101,104] Thus, in order to obtain long-lived Ru III -based antineoplastic agents, a prodrug approach, involving the decoration of the ruthenium complex with amphiphilic nanovectors, has been proposed by Paduano et al for the in vivo delivery of these compounds.…”

Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles

“…To the best of our knowledge, these are the first examples of ruthenium nanoparticles to be evaluated as potential antitumour agents. It should be noted, however, that ruthenium based lipovectors that assemble to form lamellar vesicles have recently been reported [24]. It should be noted that while most attention has been focused towards mononuclear arene ruthenium anticancer compounds [2,3,25], there has been increasing interest in polynuclear complexes [26][27][28][29], including clusters [30], which display excellent pharmacological properties.…”

Cancer nanotechnology: Recent trends and developments

“…Ruthenium and complexes of several other heavy metals have shown potential applications in cancer therapeutics. Lipid based nanovectors containing such complexes have also been put forth as a potential route in cancer 24 .…”