Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions

Hiller, John Kim; Jangmo, Andreas; Tesli, Martin; Jahołkowski, Piotr; Hoseth, Eva; Steen, Nils Eiel; Haram, Marit

doi:10.1016/j.bpsgos.2023.07.004

Cited by 4 publications

(2 citation statements)

References 148 publications

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“…All these data support previous hypotheses that lipids are essential for cell signaling and brain homeostasis, impacting neuronal membrane properties and signaling pathways [ 60 , 61 ]. Such changes in lipid metabolism can influence neuron function, potentially leading to acute neuropsychiatric disorders conditions like delirium by affecting fatty acid synthesis, membrane integrity, neuroinflammation, and neuron apoptosis [ 55 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Resultsmentioning

confidence: 99%

Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting

Viegas,

Araújo,

Ramalhete

et al. 2024

Metabolites

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Delirium presents a significant clinical challenge, primarily due to its profound impact on patient outcomes and the limitations of the current diagnostic methods, which are largely subjective. During the COVID-19 pandemic, this challenge was intensified as the frequency of delirium assessments decreased in Intensive Care Units (ICUs), even as the prevalence of delirium among critically ill patients increased. The present study evaluated how the serum molecular fingerprint, as acquired by Fourier-Transform InfraRed (FTIR) spectroscopy, can enable the development of predictive models for delirium. A preliminary univariate analysis of serum FTIR spectra indicated significantly different bands between 26 ICU patients with delirium and 26 patients without, all of whom were admitted with COVID-19. However, these bands resulted in a poorly performing Naïve-Bayes predictive model. Considering the use of a Fast-Correlation-Based Filter for feature selection, it was possible to define a new set of spectral bands with a wider coverage of molecular functional groups. These bands ensured an excellent Naïve-Bayes predictive model, with an AUC, a sensitivity, and a specificity all exceeding 0.92. These spectral bands, acquired through a minimally invasive analysis and obtained rapidly, economically, and in a high-throughput mode, therefore offer significant potential for managing delirium in critically ill patients.

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Section: Resultsmentioning

confidence: 99%

Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting

Viegas,

Araújo,

Ramalhete

et al. 2024

Metabolites

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“…All relevant papers published up to March 2024 were included. The search strategy was constructed based on both the PRISMA-ScR guidelines and prior scoping reviews of biomarker research in psychiatry [ 65 , 66 , 67 ]. In the first step of this review, a broad search strategy was used to retrieve citations related to the broad area of yoga-based interventions for depression.…”

Section: Review Processmentioning

confidence: 99%

Are There Biological Correlates of Response to Yoga-Based Interventions in Depression? A Critical Scoping Review

Rajkumar

2024

Brain Sciences

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Depression is the most common mental disorder worldwide. Both antidepressants and psychotherapy are effective in treating depression, but the response to these treatments is often incomplete. Yoga-based interventions (YBIs) have been advocated by some researchers as a promising form of alternative treatment for depression. Recent research has attempted to identify the biological mechanisms associated with the antidepressant actions of YBIs. In this scoping review, conducted according to the PRISMA-ScR guidelines, the PubMed and Scopus databases were searched to retrieve research on biomarkers of response to YBIs in patients with depression. These studies were also critically reviewed to evaluate their methodological quality and any sources of bias. Nineteen studies were included in the review. Based on these studies, there is preliminary evidence that YBIs may be associated with increased serum brain-derived neurotrophic factor (BDNF) and reduced serum cortisol and interleukin-6 (IL-6) in patients with depression. However, many of these changes were also observed in the control arms, and the overall quality of the research was low. At present, it cannot be concluded that there are reliable biomarkers of response to YBIs in depression, though there are some potential biological correlates. Further advances in this field will depend critically on improvements in study design, particularly the minimization of sources of bias and the selection of more specific and sensitive biomarkers based on existing evidence from other treatment modalities.

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Special Section: Metabolic Psychiatry

Barch

2023

Biological Psychiatry Global Open Science

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Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions

Cited by 4 publications

References 148 publications

Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting

Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting

Are There Biological Correlates of Response to Yoga-Based Interventions in Depression? A Critical Scoping Review

Special Section: Metabolic Psychiatry

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