Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

Pavel, Ileana‐Alexandra; Girardon, Maxime; Hajj, Sarah El; Parant, Stéphane; Amadei, Federico; Kaufmann, Stefan; Tanaka, Motomu; Fierro, Vanessa; Celzard, Alain; Canilho, Nadia; Pasc, Andreea

doi:10.1039/c8tb01114a

Cited by 18 publications

(16 citation statements)

References 29 publications

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“…Many of the above-mentioned aspects can be addressed by silica NPs exhibiting a lipid coating. Indeed, silica NPs can encapsulate active molecules such as drugs or diagnostic agents or enzymes (Pavel et al, 2018) in the mesoporous nanoparticle core, preventing their potential degradation (Ashley et al, 2012). On the other hand, the NP lipid coating improves NP biocompatibility and eventually controls the release of the active molecules from the NP core.…”

Section: Lipid-coated Nanoparticles Application In Nanomedicinementioning

confidence: 99%

“…On the other hand, the NP lipid coating improves NP biocompatibility and eventually controls the release of the active molecules from the NP core. Lipid digestion and the NP core overtime degradation in the non-toxic silica acid and related by-products make lipid-coated silica NPs highly biocompatible (Pavel et al, 2018). The biocompatibility of silica nanoparticles, coated with a SLB of 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[methoxy(poly(ethylene glycol))-2000] (PEG 2000 -DSPE) and Gd-DTPA-bis(stearylamide) (Gd-DTPA-DSA), is increased 10-fold compared to bare silica NPs (Van Schooneveld et al, 2008).…”

Section: Lipid-coated Nanoparticles Application In Nanomedicinementioning

confidence: 99%

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Understanding the Nano-bio Interfaces: Lipid-Coatings for Inorganic Nanoparticles as Promising Strategy for Biomedical Applications

2019

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Inorganic nanoparticles (NPs) exhibit relevant physical properties for application in biomedicine and specifically for both the diagnosis and therapy (i.e. theranostic) of severe pathologies, such as cancer. The inorganic NP core is often not stable in aqueous suspension and can induce cytotoxic effects. For this reason, over the years, several coating strategies were suggested to improve the NP stability in aqueous solutions as well as the NP biocompatibility. Among the various components which can be used for NP coatings, lipids, and in particular phospholipids emerged as versatile molecular building blocks for the production of NP coatings suitable for biomedical application. The recent synthetic efforts in NP lipid coatings allows today to introduce on the NP surface a large variety of lipid molecules eventually in mixture with amphiphilic or hydrophobic drugs or active molecules for cell targeting. In this review, the most relevant examples of NP lipid-coatings are presented and grouped in two main categories: supported lipid bilayers (SLB) and hybrid lipid bilayers (HLB). The discussed scientific cases take into account the most commonly used inorganic NP for biomedical applications in cancer therapy and diagnosis.

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Section: Lipid-coated Nanoparticles Application In Nanomedicinementioning

confidence: 99%

Section: Lipid-coated Nanoparticles Application In Nanomedicinementioning

confidence: 99%

Understanding the Nano-bio Interfaces: Lipid-Coatings for Inorganic Nanoparticles as Promising Strategy for Biomedical Applications

2019

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“…26 Lipid-coated MSNs have been reported to have a 10-fold higher half-life and biocompatibility compared to those of bare silica. 27 The goal of this study is to explore the potential of lipidcoated MSNs for the controlled and targeted delivery of BBR to improve the in vivo performance. To achieve this goal, MSNs were synthesized with the Stober process, and the synthesized MSNs were loaded with BBR using the "passive method".…”

Section: Introductionmentioning

confidence: 99%

Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation

Singh

Rathore

et al. 2021

ACS Biomater. Sci. Eng.

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Selective permeability of the blood–brain barrier limits effective treatment of neurodegenerative disorders. In the present study, brain-targeted lipid-coated mesoporous silica nanoparticles (MSNs) containing berberine (BBR) were synthesized for the effective treatment of Alzheimer’s disease (AD). The study involved synthesis of Mobil Composition of Matter-41 (MCM-41) mesoporous silica nanoparticles (MSNs), BBR loading, and lipid coating of MSNs (MSNs-BBR-L) and in vitro and in vivo characterization of MSNs-BBR-L. The liposomes (for lipid coating) were prepared by the thin-film hydration method. Transmission electron microscopy (TEM) images indicated 5 nm thickness of the lipid coating. Dynamic light scattering (DLS) and TEM results confirmed that the size of synthesized MSNs-BBR-L was in the range of 80–100 nm. The X-ray diffraction (XRD) pattern demonstrated retention of the ordered structure of BBR after encapsulation and lipid coating. Fourier transform infrared (FTIR) spectrum confirmed the formation of a lipid coat over the MSN particles. MSNs-BBR-L displayed significantly (p < 0.05) higher acetylcholine esterase (AChE) inhibitory activity. The study confirmed significant (p < 0.05) amyloid fibrillation inhibition and decreased the malondialdehyde (MDA) level by MSNs-BBR-L. Pure BBR- and MSNs-BBR-L-treated AD animals showed a significant decrease in the BACE-1 level compared to scopolamine-intoxicated mice. Eight times higher area under the curve for MSNs-BBR-L (2400 ± 27.44 ng h/mL) was recorded compared to the pure BBR (295.5 ± 0.755 ng h/mL). Overall, these results highlight the utility of MSNs-BBR-L as promising drug delivery vehicles for brain delivery of drugs.

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“…Some types of nanoparticles, such as inorganic, are coated with lipids in order to enhance their biocompatibility [107]. Such coatings also help to control the release of drugs and improve their biopharmaceutical properties [108]. However, the criteria of long circulation time are widely debated recently, because it could be beneficial only for those NDDs that have a better tumor accumulation due to EPR effect [72].…”

Section: Biopharmaceutical Properties and Anticancer Activitymentioning

confidence: 99%

Challenges towards Targeted Drug Delivery in Cancer Nanomedicines

2021

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Despite cancer nanomedicine celebrates already thirty years since its introduction, together with the achievements and progress in cancer treatment area, it still undergoes serious disadvantages that must be addressed. Since the first observation that macromolecules tend to accumulate in tumor tissue due to fenestrated endothelial of vasculature, considered as the “royal gate” in drug delivery field, more than dozens of nanoformulations have been approved and introduced into the practice for cancer treatment. Lipid, polymeric, and hybrid nanocarriers are biocompatible nano-drug delivery systems (NDDs) having suitable physicochemical properties and modulate payload release in response to specific chemical or physical stimuli. Biopharmaceutical properties of NDDs and their efficacy in animal models and humans can significantly affect their impact and perspective in nanomedicine. One of the future directions could be focusing on personalized cancer treatment, considering the heterogeneity and complexity of each patient tumor tissue and the designing of multifunctional targeted NDDs combining synthetic nanomaterials and biological components, like cellular membranes, circulating proteins, RNAi/DNAi, which enforce the efficacy of NDDs and boost their therapeutic effect.

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Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

Abstract: Coating of mesoporous silica carriers with dioleoylphosphatidylcholine allowed triggering of the selective delivery of functional enzymes by lipolysis under simulated intestinal conditions.

Cited by 18 publications

References 29 publications

Understanding the Nano-bio Interfaces: Lipid-Coatings for Inorganic Nanoparticles as Promising Strategy for Biomedical Applications

Understanding the Nano-bio Interfaces: Lipid-Coatings for Inorganic Nanoparticles as Promising Strategy for Biomedical Applications

Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation

Challenges towards Targeted Drug Delivery in Cancer Nanomedicines

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