Lipid composition of the matrix of human submandibular salivary gland stones

Slomiany, Bronislaw L.; Murty, V.L.N.; Aono, Mitsuru; Slomiany, Amalia; Mandel, Irwin D.

doi:10.1016/0003-9969(82)90191-1

Cited by 31 publications

(23 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…25,28,36 Few sialoliths are constituted of only organic material; most salivary stones contain calcium phosphates, either as hydroxyapatite or carbonate apatite. 52,61 The organic matrix comprises approximately 20% of the dry weight of parotid stones. Submandibular stones contain less organic material: approximately 9-12% of the dry weight.…”

Section: Biochemical Compositionmentioning

confidence: 99%

See 1 more Smart Citation

Salivary stones: symptoms, aetiology, biochemical composition and treatment

et al. 2014

View full text Add to dashboard Cite

Salivary stones, also known as sialoliths, are calcified concrements in the salivary glands. Sialoliths are more frequently located in the submandibular gland (84%), than in the parotid gland (13%). The majority of the submandibular stones are located in Wharton's duct (90%), whereas parotid stones are more often located in the gland itself. Salivary stones consist of an amorphous mineralised nucleus, surrounded by concentric laminated layers of organic and inorganic substances. The organic components of salivary stones include collagen, glycoproteins, amino acids and carbohydrates. The major inorganic components are hydroxyapatite, carbonate apatite, whitlockite and brushite. The management of salivary stones is focused on removing the salivary stones and preservation of salivary gland function which depends on the size and location of the stone. Conservative management of salivary stones consists of salivary gland massage and the use of sialogogues. Other therapeutic options include removal of the stone or in some cases surgical removal of the whole salivary gland.

show abstract

Section: Biochemical Compositionmentioning

confidence: 99%

“…62,63 The organic part consists of collagen, neutral and acid glycoproteins, other proteins, lipids and carbohydrates such as glucose and mannose. 33,60,61,63 In submandibular stones, protein contributes approximately 5% to the stone weight whereas lipids contribute 1%. 61,63…”

Section: Biochemical Compositionmentioning

confidence: 99%

Salivary stones: symptoms, aetiology, biochemical composition and treatment

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Kiittner (2) in 1896 eonsideted the possibilities that salivary calculi might be primary or secondary to chronic sialadenitis, and that they trtight arise ftotn an irtegularity of the ductal lining, in an obstructed lobule, or frotn bacteria fortning a deposit. Although thctc have been tnany subsequent studies using a variety of techtiiques (1,(3)(4)(5)(6)(7)(8)(9)(10), the genesis of salivary calculi has not been established. Thus the fortuitous observation of inttacellular tnicrocalculi in nortnal sublingual salivary glands of cats used in an experimental study (11,12) led to the present investigation.…”

mentioning

confidence: 99%

Ultrastructural and histochemical observations on intracellular and luminal microcalculi in the feline sublingual salivary gland

Epivatianos

Harrison

Garrett

et al. 1986

J Oral Pathology Medicine

View full text Add to dashboard Cite

Epivatianos A, Harrison JD, Garrett JR, Davies KJ, Senkus R. Ultrastructural and histochemical obseivations on intracellular and luminal tiiictocalculi in the feline sublingual salivaty gland. J Otal Pathol 1986: 15: 513-517.As the genesis of salivaiy calculi in man has not been established, the fortuitous observation of tnicrocalculi iti sublingual glarids of cats ptotnpted this study. Microcalculi wete seen occasionally within acinar cells and lutnina and macrophages, and rately intetstitially. Miciocalculi wete stained with the periodic-acid/Schilf technique, and acid-phosphatase activity was associated with intracellular microcalculi. Intracellular microcalculi were seen ultrastructurally in acinar cells in membrane-bound vacuoles that also contaiticd debris and sometimes what appeated to be secretory tnaterial. X-ray tnicroanalysis showed the mictocalculi to consist of crystals containing calciutn and phosphorus. The observations suggest that the tnicrocalculi fortn within autophagosotncs in acinar cells by a ptecipitatioti of calciutn and phosphorus ptesent in degenerate tnaterial, and that (he tniciocalculi eventually enter lutnina, whete they tnay be dischatgcd in the saliva or retaiticd and enlarge.

show abstract

“…Untersuchungen zur Genese der Mikrolithen im Tiermodell [52] zeigten, dass diese durch Autophagozytose von kalziumreichen Zellorganellen entstehen. Hinweise für diesen Mechanismus der Bildung von Mikrolithen in Analogie beim Menschen nannten auch andere Autoren [24,25,54,76,180,194]. Die Häu-figkeit der Bildung von Mikrolithen ist umgekehrt proportional zur Sekretionsleistung der jeweiligen Speicheldrüsen [77,207].…”

Section: Ursachen Der Sialolithiasisunclassified

“…submandibularis überwiegend aus anorganischen Substanzen ± gerade im Submandibularisspeichel ist das Löslichkeitsprodukt für verschiedene Kalziumverbindungen oft überschritten [176,194]. Bei Steinen der Gl.…”

Section: Ursachen Der Sialolithiasisunclassified

Die Sialolithiasis und deren Behandlung

Zenk¹,

H²

2001

Laryngorhinootologie

View full text Add to dashboard Cite

Lipid composition of the matrix of human submandibular salivary gland stones

Cited by 31 publications

References 16 publications

Salivary stones: symptoms, aetiology, biochemical composition and treatment

Salivary stones: symptoms, aetiology, biochemical composition and treatment

Ultrastructural and histochemical observations on intracellular and luminal microcalculi in the feline sublingual salivary gland

Die Sialolithiasis und deren Behandlung

Contact Info

Product

Resources

About