Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles

Sorita, Guilherme Dallarmi; Santamaria‐Echart, Arantzazu; Gozzo, Angela Maria; Gonçalves, Odinei Hess; Leimann, Fernanda Vitória; Manrique, Yaidelin A.; Fernandes, Isabel P.; Barreiro, María Filomena

doi:10.1016/j.apt.2021.03.028

Cited by 22 publications

(10 citation statements)

References 76 publications

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“…The bands from 1575 to 1608 cm −1 are attributed to the C=C stretching vibrations of aromatic rings, and the bands located at 1130-1160 cm −1 are from ether (C-O-C) groups in the structure of CUR. The peaks at around 1500 cm −1 are attributed to stretching vibrations of C-C bands present in the aromatic ring, and signals observed in the region between 700-900 cm −1 are assigned to C-H bands of CUR [57]. Furthermore, FTIR spectra of microparticles revealed the presence of characteristic signals for sodium alginate.…”

Section: Characterisation Of the Obtained Multifunctional Microcarriersmentioning

confidence: 97%

Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function

et al. 2022

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The design of multifunctional microcarriers has attracted significant attention because they combine various functions within a single system. In this study, we developed a set of multilayered hydrogel microcarriers, which were first loaded with chemotherapeutic curcumin (CUR), then, using the layer-by-layer (LbL) technique, coated through a polyelectrolyte shell consisting of chitosan (CHIT) or poly(allylamine hydrochloride) (PAH). As an outer layer with antimicrobial function, newly synthesised alkylene quaternary ammonium salt functionalised polyelectrolytes (A-QAS-PEs) were applied. For this purpose, poly(acrylic acid) (PAA) was decorated with different hydrophobic side chains (n-hexane and n-dodecane side entities) and different degrees of substitution (m) of quaternary ammonium groups (abbreviated as PAA-C(O)O-(CH2)n-N+(CH3)3(m); n = 6, 12; m = 8–14%). The grafting approach of PAA with the alkylene quaternary ammonium salt moiety was performed under mild reaction conditions using Steglich esterification followed by quaternisation. The structure of antimicrobial decorated PAA was confirmed by 1H NMR and FTIR, and the mean diameter of all multifunctional microparticles was characterised by SEM. The viscoelastic properties of the functional layers were studied using quartz crystal microbalance with a dissipation (QCM-D). The release of CUR from the microcarriers was described using a hybrid model, i.e., a combination of first-order kinetics and the Korsmeyer-Peppas model. The antimicrobial activity of functionalised PAA and multilayered CUR-loaded hydrogel microcarriers with quaternary ammonium function was assessed against Staphylococcus aureus and Serratia marcescens by the agar diffusion assay method. Only a limited inhibition zone of PAA was observed, but in the case of both antimicrobial decorated PAA and the corresponding multilayered nanocarriers, the inhibitory activity increase was achieved against both strains of bacteria.

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Section: Characterisation Of the Obtained Multifunctional Microcarriersmentioning

confidence: 97%

Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function

et al. 2022

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“…It is affected by the process (operating parameters and equipment) and formulation variables (e.g. hydrophilic or hydrophobic active ingredient and characteristics of the encapsulating material) ( Bertoni, Albertini, & Passerini, 2019 ; Sorita et al, 2021 ).…”

Section: Properties Of the Microencapsulation Process By Spray Chillingmentioning

confidence: 99%

“…Microencapsulation by spray chilling consists of the formation of solid lipid microparticles through the atomization of active ingredients that can be of hydrophilic or hydrophobic origin, dissolved or dispersed in molten lipid encapsulating materials ( Oriani et al, 2016 ). It is possible to obtain a solution, emulsion, or dispersion, depending on the solubility of the compounds, which is atomized in a refrigeration chamber, in which the droplets solidify when in contact with cold air, giving rise to solid lipid microparticles with characteristics of a powdered product ( Sorita et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation by spray chilling in the food industry: Opportunities, challenges, and innovations

Figueiredo

Silva

Oliveira

et al. 2022

Trends in Food Science & Technology

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“…The literature reports three classes of methods that have been used for micro- or nanoparticle formulations. The method used to produce the particles affects the encapsulation efficiency and can be classified as (i) physical methods: spray-drying and freeze-drying (Geranpour et al, 2020 ; Okino et al, 2021 ; Sorita et al, 2021 ; Waterhouse et al, 2017 ); (ii) physical–chemical methods: coacervation, emulsification, and supercritical fluid micronization (Mendonça et al, 2019 ; Rudke et al, 2019 ); and (iii) chemical methods: interfacial polymerization and complexation by molecular inclusion (Vakilinezhad et al, 2019 ).…”

Section: Encapsulation Strategies To Improve Proanthocyanidin/procyan...mentioning

confidence: 99%

Phenolic Fraction from Peanut (Arachis hypogaea L.) By-product: Innovative Extraction Techniques and New Encapsulation Trends for Its Valorization

Sorita

Leimann

Ferreira

2022

Food Bioprocess Technol

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Peanut skin is a by-product rich in bioactive compounds with high nutritional and pharmaceutical values. The phenolic fraction, rich in proanthocyanidins/procyanidins, is a relevant class of bioactive compounds, which has been increasingly applied as functional ingredients for food and pharmaceutical applications and is mostly recovered from peanut skins through low-pressure extraction methods. Therefore, the use of green high-pressure extractions is an interesting alternative to value this peanut by-product. This review addresses the benefits of the phenolic fraction recovered from peanut skin, with a focus on proanthocyanin/procyanidin compounds, and discusses the improvement of their activity, bioavailability, and protection, by methods such as encapsulation. Different applications for the proanthocyanidins, in the food and pharmaceutical industries, are also explored. Additionally, high-pressure green extraction methods, combined with micro/nanoencapsulation, using wall material derived from peanut industrial processing, may represent a promising biorefinery strategy to improve the bioavailability of proanthocyanidins recovered from underutilized peanut skins.

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Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles

Cited by 22 publications

References 76 publications

Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function

Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function

Microencapsulation by spray chilling in the food industry: Opportunities, challenges, and innovations

Phenolic Fraction from Peanut (Arachis hypogaea L.) By-product: Innovative Extraction Techniques and New Encapsulation Trends for Its Valorization

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