Lipid content in the musculature of the lower leg assessed by fat selective MRI: Intra‐ and interindividual differences and correlation with anthropometric and metabolic data

Machann, Jürgen; Bachmann, Oliver; Brechtel, Klaus; Dahl, Dominik; Wietek, Beate; Klumpp, Bernhard; Häring, H.-U.; Claussen, Claus D.; Jacob, Stephan; Schick, Fritz

doi:10.1002/jmri.10255

Cited by 70 publications

(72 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this fatty depot, lipids are stored as adipocytes located between and within individual skeletal muscle groups (interand intramuscular fat, respectively), or as fat droplets within the muscle cells' cytoplasm (intramyocellular lipids (IMCL)). The fat concentration varies greatly over the compartment (4,8,9), and fat concentrations below 0.5 % may be expected in some muscle groups (10).…”

Section: Fat Quantification In Skeletal Muscle Using Multigradient-ecmentioning

confidence: 99%

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

Peterson

Romu

Brorson

et al. 2015

J. Magn. Reson. Imaging

View full text Add to dashboard Cite

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal 1 Fat quantification in skeletal muscleFat quantification in skeletal muscle using multigradient-echo imaging: comparison of fat and water references 2 Fat quantification in skeletal muscle AbstractPurpose: To compare the precision, accuracy, and repeatability of water/fat imaging-based fat quantification in muscle tissue using small or large flip angles (FAs), and a water or fat reference for calculation of the proton density fat fraction (FF). Materials and methods:An Intralipid phantom and both forearms of six patients suffering from lymphedema and ten healthy volunteers were investigated in a 1.5T scanner. Two multigradient-echo sequences with eight echo times and FAs of 10° and 85° were acquired, respectively. For healthy volunteers, the acquisition of the right arm was performed twice with repositioning. From each set, water reference FF and fat reference FF images were reconstructed and the average FF and the standard deviation were calculated within the subfascial compartment. The small FA water reference was considered the reference standard.Results: The use of a fat reference effectively avoided bias due to T 1 weighting when using a large FA. The large FA fat reference approach also resulted in the highest precision, but no significant difference in repeatability between the various methods was detected. Conclusion:The precision of fat quantification in muscle tissue can be increased with maintained accuracy using a larger flip angle, if a fat reference instead of a water reference is used.

show abstract

Section: Fat Quantification In Skeletal Muscle Using Multigradient-ecmentioning

confidence: 99%

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

Peterson

Romu

Brorson

et al. 2015

J. Magn. Reson. Imaging

View full text Add to dashboard Cite

show abstract

“…Schick et al (120)(121)(122)(123) suggested and used fatselective imaging sequences based on spatial-spectral excitation that provides highly selective fat images of musculature and allows a quantitative assessment of the muscular fat in vivo. Binomial pulse trains allow selective excitation of spin ensembles in a specific chemical shift range (124).…”

Section: Mri Of Muscular Fat and Estimation Of Other Lipid Compartmenmentioning

confidence: 99%

“…Two examples in the lower row illustrate the performance of the sequence in vivo. Fat-selective images of a 28-yearold insulin-sensitive male volunteer (a) and a 34-year-old insulin-resistant male volunteer (b) show the higher amount of lipids in all muscle groups of the patient (123). The homogeneous background signal is due to IMCL.…”

Section: Combination Of 1 H-mrs Of Imcl and Other Mrs Techniquesmentioning

confidence: 99%

Role of proton MR for the study of muscle lipid metabolism

et al. 2006

Self Cite

View full text Add to dashboard Cite

1 H-MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became particularly important when it was recognized that IMCL levels are related to insulin sensitivity. While this relation is rather complex and depends on the training status of the subjects, various other influences such as exercise and diet also influence IMCL concentrations. This may open insight into many metabolic interactions; however, it also requires careful planning of studies in order to control all these confounding influences. This review summarizes various historical, methodological, and practical aspects of 1 H-MR spectroscopy (MRS) of muscular lipids. That includes a differentiation of bulk magnetic susceptibility effects and residual dipolar coupling that can both be observed in MRS of skeletal muscle, yet affecting different metabolites in a specific way. Fitting of the intra-(IMCL) and extramyocellular (EMCL) signals with complex line shapes and the transformation into absolute concentrations is discussed. Since the determination of IMCL in muscle groups with oblique fiber orientation or in obese subjects is still difficult, potential improvement with high-resolution spectroscopic imaging or at higher field strength is considered. Fat selective imaging is presented as a possible alternative to MRS and the potential of multinuclear MRS is discussed. 1 H-MRS of muscle lipids allows non-invasive and repeated studies of muscle metabolism that lead to highly relevant findings in clinics and patho-physiology.

show abstract

“…Several studies performed in obese individuals have demonstrated a correlation between the amount of ectopic lipid stores found inside SkM cells, referred to as intramyocellular lipids (IMCL), and parameters of lipid oversupply like body mass index (BMI), waist-to-hip ratio, central adiposity, and percent body fat (32,66,73,101). Whereas small amounts of intracellular triglycerides represent an important energy source especially for skeletal and cardiac muscle in periods of low glucose supply, increasing amounts of ectopic lipid depositions have been demonstrated to be able to impair organ function, known as lipotoxicity.…”

Section: Ectopic Lipid Stores Impair Organ Functionmentioning

confidence: 99%