Lipid-core nanocapsules: mechanism of self-assembly, control of size and loading capacity

Abstract

Nanotechnology in pharmaceutics has the potential to improve drug efficacy by influencing drug distribution in tissues. Nanocarriers have been developed as drug delivery systems to be administered by different biological routes. To ensure the nanotechnological properties, pre-formulation studies are especially critical in determining the influence of the process parameters on the size and polydispersity of particles. Thus, the objective of this work was to establish the mechanism of self-assembly, by determining the influence of the critical aggregation concentration of the materials in the organic phase on the final average particle size and polydispersity of polymeric lipid-core nanocapsules obtained by interfacial deposition of polymer. Measurements of the surface tension and viscosity of the organic and aqueous phases were correlated with the particle size and the concentration of raw materials. We demonstrated that the lipid-core nanocapsules are formed on the nanoscopic scale as unimodal distributions, if the aggregation state of raw materials in the organic phase tends to infinite dilution. The strategy for controlling the particle size distribution is a valuable tool in producing lipid-core nanocapsule formulations with different loading capacities intended for therapeutics.

Controlled release of raloxifene by nanoencapsulation: effect on in vitro antiproliferative activity of human breast cancer cells

“…Furthermore, this analysis allowed the observation of the Brownian motion of the individual nanoparticles. 25 …”

“…Furthermore, in order to reject the hypothesis that the higher numbers of particles in the nanocapsule suspensions of Eudragit ® RS100 were related to the formation of nanocrystals due to the presence of excessive raloxifene, scattering intensity and size distribution between NC-RS and RH-NC-RS were correlated. According to Jornada et al 25 scattering intensity of colloids varies with the presence of drug nanocrystals. When comparing these formulations, blank nanocapsules show a similar plot by NTA as RH-loaded nanocapsules and we can suggest that drug nanocrystals do not exist in our formulations.…”

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

“…30 The polymer, PCL (0.1 g), sorbitan monostearate (0.038 g), capric/caprylic triglyceride (0.165 mL) and Hst (0.005 g) were dissolved in acetone (27 mL). In another flask, polysorbate 80 (0.077 g) was dispersed in 53 mL of water.…”

The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways

“…[21][22][23] At 40°C, indomethacin (0.010 g), poly(ε-caprolactone) (0.100 g), capric/caprylic triglycerides (0.33 mL), and sorbitan monostearate (0.077 g) were dissolved in acetone (27 mL). In a separate flask, polysorbate 80 (0.077 g) was added to 53 mL of water.…”