Lipid-dendrimer hybrid nanosystem as a novel delivery system for paclitaxel to treat ovarian cancer

Liu, Yuanjie; Ng, Y.K.; Toh, Ming Ren; Chiu, Gigi N.C.

doi:10.1016/j.jconrel.2015.11.004

Cited by 51 publications

(21 citation statements)

References 47 publications

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“…These molecules have two major drawbacks: low hydrosolubility and high nonspecific toxicity. Hence, the use of dendrimers is a promising strategy [ 70 , 71 , 72 , 73 ].…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focused on dendrimer complexes of ibuprofen, indomethacin, piroxicam, ketoprofen and diflunisal. In the context of the development of antibiotic-resistant bacterial strains, dendrimer complexes of fluoroquinolones, macrolides, beta-lactamines and aminoglycosides have shown promising effects. Regarding antiviral therapy, studies have been performed to develop dendrimer conjugates with tenofovir, maraviroc, zidovudine, oseltamivir and acyclovir, among others. Furthermore, cardiovascular therapy has strongly addressed dendrimers. Employed in imaging diagnostics, dendrimers reduce the dosage required to obtain images, thus improving the efficiency of radioisotopes. Dendrimers are macromolecular structures with multiple advantages that can suffer modifications depending on the chemical nature of the drug that has to be transported. The results obtained so far encourage the pursuit of new studies.

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“…These molecules have two major drawbacks: low hydrosolubility and high nonspecific toxicity. Hence, the use of dendrimers is a promising strategy [ 70 , 71 , 72 , 73 ].…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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“…In addition, these drugs are associated with toxic effects due to lack of tumor specificity. Dendrimers have emerged in as promising platforms for these molecules [ 41 , 128 , 129 , 130 , 131 ] and Table 3 presents a summary of the main studies discussed in this section.…”

Section: Dendrimers As Drug Delivery Carriers In Cancer Therapymentioning

confidence: 99%

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

2017

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Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them promising structures for functionalization and also for conjugation with drugs and DNA/RNA. Their architecture, which can be controlled by different synthesis processes, allows the control of characteristics such as shape, size, charge, and solubility. Dendrimers have the ability to increase the solubility and bioavailability of hydrophobic drugs. The drugs can be entrapped in the intramolecular cavity of the dendrimers or conjugated to their functional groups at their surface. Nucleic acids usually form complexes with the positively charged surface of most cationic dendrimers and this approach has been extensively employed. The presence of functional groups in the dendrimer’s exterior also permits the addition of other moieties that can actively target certain diseases and improve delivery, for instance, with folate and antibodies, now widely used as tumor targeting strategies. Dendrimers have been investigated extensively in the medical field, and cancer treatment is one of the greatest areas where they have been most used. This review will consider the main types of dendrimer currently being explored and how they can be utilized as drug and gene carriers and functionalized to improve the delivery of cancer therapy.

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“…The delivery of paclitaxel ( 4 ) for the treatment of ovarian cancer using lipid-dendrimer hybrid has been investigated [ 30 ]. Paclitaxel is a hydrophobic anticancer drug used for treatment of various cancers.…”

Section: Experimental Insights On Pamam-drug Interactions For Enhamentioning

confidence: 99%

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

et al. 2018

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Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers in pre-clinical and clinical settings. Besides formulation strategies, factors such as pH, PAMAM dendrimer generation, PAMAM dendrimer concentration, nature of the PAMAM core, special ligand and surface modifications of PAMAM dendrimer have an influence on drug solubility and other recommendable pharmacological properties. This review, therefore, compiles the recently reported applications of PAMAM dendrimers in pre-clinical and clinical uses as enhancers of solubility and other desirable properties such as sustained and controlled release, bioavailability, bio-distribution, toxicity reduction or enhancement, and targeted delivery of small molecules with emphasis on cancer treatment.

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Lipid-dendrimer hybrid nanosystem as a novel delivery system for paclitaxel to treat ovarian cancer

Cited by 51 publications

References 47 publications

Applications and Limitations of Dendrimers in Biomedicine

Applications and Limitations of Dendrimers in Biomedicine

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

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