Lipid droplet-hitchhiking probe creates Trojan foam cells for fluorescence/photoacoustic imaging of atherosclerotic plaques

Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

“…Additionally, under low-intensity focused ultrasound irradiation, the PFP-HMME@PLGA/MnFe 2 O 4 -Ram group showed substantially enhanced US signals that reached their peak at 4 min post-injection in plaque-bearing rabbits. Lastly, in vivo PA imaging revealed gradually remarkable signals of plaques that peaked at 90 min in the PFP-HMME@PLGA/MnFe 2 O 4 -Ram group compared to the control [201] Copyright 2022, Elsevier. F) Schematic illustration of the construction and application of PFP-HMME@PLGA/MnFe 2 O 4 -Ram nanoplatform.…”

“…( Figure A). [ 201 ] The nanoprobe exploited the homologous targeting effect of Trojan foam cells to hitchhike on the LD, facilitating precise localization within plaque region (Figure 8B,C). The ICG had both FL and PA signals, which were available for imaging in either the FL or PA modality.…”

Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

“…Inspired by this, Zhu et al prepared an LD-hitchhiking liposome (DCP) with high cell internalization and plaque accumulation capacity consisting of dioleoylphosphatidylserine (DOPS) as a LD inducer and cypate (an analog of ICG)-grafted lysophosphocholine (Cypate-PC) as a probe for FL/PA bimodal imaging of atherosclerotic plaques (Figure 14A). [195] Cypate-PC shared similar FL/PA performance as ICG and could be used for FL/PA imaging in vivo. After intravenous injection, DCP liposomes were ingested by monocytes and DOPS of DCP liposomes induced the generation of LDs in monocytes, resulting in monocytes (termed Trojan foam cells) displaying similar features as foam cells.…”

“…These results demonstrated that both A-E) Reproduced with permission. [195] Copyright 2022, Elsevier.…”

“…D) FL images of mice after different treatments. E) US and PA images of long-axis sections of mice after different treatments.A-E) Reproduced with permission [195]. Copyright 2022, Elsevier.…”