Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob

Picard, John; Meek, T.

doi:10.1111/j.1365-2044.2005.04494.x

Cited by 86 publications

(59 citation statements)

References 9 publications

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“…This is the first report of the use of lipid emulsion in a peri-arrest situation. The use of lipid emulsion has previously been recommended after standard resuscitative measures have proven ineffective as its safety is unknown when administered in the high doses used in lipid rescue [12,13]. However, pretreatment with a lipid infusion has been shown to increase the bupivacaine dose required to induce asystole in rats [2].…”

Section: Discussionmentioning

confidence: 99%

Levobupivacaine‐induced seizures and cardiovascular collapse treated with Intralipid^®

McCahon²,

et al. 2007

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Summary Lipid emulsion has been used in the successful treatment of local anaesthetic‐induced cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous reports of levobupivacaine toxicity in humans have been characterised by neurological signs and symptoms, without serious cardiovascular events. We present a case in which presumed intravenous injection of levobupivacaine led to neurological and cardiovascular consequences. This was treated successfully by resuscitation that included intravenous Intralipid® infusion.

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Section: Discussionmentioning

confidence: 99%

Levobupivacaine‐induced seizures and cardiovascular collapse treated with Intralipid^®

McCahon²,

et al. 2007

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“…These studies did not employ adrenaline as part of their resuscitation protocols. 1,3,26 However, current American Heart Association Advanced Cardiac Life Support protocol advocates the use of adrenaline during CPR. 46 These conflicting approaches have initiated research regarding the relevant role of lipid in resuscitation.…”

Section: The Use Of Propofol For Lipid Rescuementioning

confidence: 99%

“…36 Human case reports 11,19,20,[37][38][39][40][41][42][43][44][45] describing successful lipid rescue are therefore invaluable. 26 When should lipid therapy be started?…”

Section: Reviewmentioning

confidence: 99%

“…25 The lipid flux theory is based on the powerful ability of local anaesthetics to inhibit the carnitine transporter system, the enzyme system responsible for transfer of long-chain fatty acids into the mitochondrial matrix for β-oxidation. 4,9,26,27 Administration of lipid emulsion provides medium-and short-chain fatty acids to supply the mitochondria with sufficient substrate. 26,28 Weinberg suggests that restoring the heart's preferred fuel supply (fatty acids) could explain why resuscitation is so rapid following lipid emulsion.…”

Section: Reviewmentioning

confidence: 99%

“…4,9,26,27 Administration of lipid emulsion provides medium-and short-chain fatty acids to supply the mitochondria with sufficient substrate. 26,28 Weinberg suggests that restoring the heart's preferred fuel supply (fatty acids) could explain why resuscitation is so rapid following lipid emulsion. 28 There is collateral evidence supporting the lipid flux hypothesis.…”

Section: Reviewmentioning

confidence: 99%

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