Lipid emulsion treatment of amlodipine toxicity

Lipid Emulsion Treatment of Nonlocal Anesthetic Drug Toxicity

“…13 Thus, after lipid emulsion ameliorates the hemodynamic depression induced by drug toxicity and decreases the dosage of vasopressor (norepinephrine and dopamine) required for the treatment of hemodynamic depression in nonlocal anesthetic drug toxicity, earlier termination of lipid emulsion administration may produce recurrence of hemodynamic depression or re-elevation of plasma amlodipine concentration because the half-life of lipid emulsion is much shorter than that of these lipid soluble nonlocal anesthetic drugs. 14 In addition, the timing of lipid emulsion administration in most cases of toxicity induced by nonlocal anesthetic drugs is only at the terminal stage when there is intractable cardiovascular collapse (Table 1). Thus, further research regarding the optimal dosing regimen and timing of lipid emulsion treatment in nonlocal anesthetic drug toxicity and the pharmacokinetic interaction of lipid emulsion with various offending drugs that induce toxicity after oral administration is needed.…”