Lipid-enveloped zinc phosphate hybrid nanoparticles for codelivery of H-2Kb and H-2Db-restricted antigenic peptides and monophosphoryl lipid A to induce antitumor immunity against melanoma

Zhuang, Xiangting; Wang, Tingting; Zhao, Yongdan; Hu, Xiaomeng; Bao, Yuling; Guo, Yuanyuan; Song, Qingle; Gao, Li; Tan, Songwei; Zhang, Zhiping

doi:10.1016/j.jconrel.2016.02.035

Cited by 74 publications

(50 citation statements)

References 45 publications

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“…It is likely that TRP2 was successfully encapsulated within EXOs via pore formation in the EXO membranes by saponin during incubation. Although the loading efficiency of TRP2 was not greater than those from previous studies that used zinc phosphate nanoparticles and liposome‐coated gold nanoparticles, our study is the first report of a peptide antigen loading method for TRP2 within EXOs via saponin incubation.…”

contrasting

confidence: 66%

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Park

Choi

et al. 2018

Macromolecular Bioscience

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Exosomes (EXO) are considered to be versatile carriers for biomolecules; however, the delivery of therapeutic peptides using EXOs poses several challenges. In this study, the efficiency of serum‐derived EXOs in delivering tyrosinase‐related protein‐2 (TRP2) peptides to lymph nodes is determined. TRP2 peptides are successfully incorporated into EXOs, which show a uniform and narrow size distribution of around 45 nm. The TRP2‐incorporated exosomes (EXO‐TRP2) are efficiently internalized into macrophages and dendritic cells, and are seen to display a punctate distribution. EXOs loaded with TRP2 together with MPLA, (EXO‐MPLA‐TRP2) result in a strong release of proinflammatory cytokines (TNF‐α and IL‐6) from both RAW264.7 and DC2.4 cells. Finally, subcutaneous injection of fluorescently labeled EXO‐TRP2 followed by ex vivo imaging using in vivo imaging system (IVIS) show a strong fluorescent signal in the lymph nodes after only 1 h, which is maintained until at least 4 h after injection. Taken together, the findings suggest that serum‐derived EXOs can serve as promising carriers to deliver therapeutic peptides to lymph nodes for immunotherapy.

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contrasting

confidence: 66%

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Park

Choi

et al. 2018

Macromolecular Bioscience

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“…Zhang et al designed lipid-coated zinc phosphate hybrid nanoparticles coupled with vaccine based on the specific immune response in vivo, in order to transfer peptide and adjuvant to achieve tumor immunotherapy. 77 Based on the study of metastatic melanoma model, it was confirmed that the nano-vaccine could enhance the presentation of tumor antigen and induce cytotoxic T lymphocytes (CTL) response, and enhance the monitoring of immune system to tumor growth, metastasis. This nanoparticle-based vaccine can also be applied for the treatment of other tumors and thus has a bright future in the tumor immune treatment.…”

Section: Main Types Of Nanoparticles Liposomesmentioning

confidence: 97%

“…This nanoparticle-based vaccine can also be applied for the treatment of other tumors and thus has a bright future in the tumor immune treatment. 77 …”

Section: Main Types Of Nanoparticles Liposomesmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

132

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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“…In 2017, Nel and co‐workers developed mesoporous silica nanoparticles to deliver an indoleamine 2,3‐dioxygenase (IDO) inhibitor (blocking the immunosuppressive IDO pathway) and a chemotherapeutic drug (oxaliplatin) to attenuate tumor growth . Last, Zhang and co‐workers developed a liposome‐coated zinc phosphate hybrid nanoparticle for coencapsulating the antigenic peptides (TRP2 and GP100) and monophosphoryl lipid A (MPLA) (a TLR4 agonist) …”

Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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Lipid-enveloped zinc phosphate hybrid nanoparticles for codelivery of H-2Kb and H-2Db-restricted antigenic peptides and monophosphoryl lipid A to induce antitumor immunity against melanoma

Cited by 74 publications

References 45 publications

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Materials for Immunotherapy

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