Lipid-hybrid cell-derived biomimetic functional materials: A state-of-the-art multifunctional weapon against tumors

Liu, Wen-Shang; Wu, Lili; Chen, C.H.; Zheng, Hongliang; Gao, Jie; Lu, Zhengmao; Li, Meng

doi:10.1016/j.mtbio.2023.100751

Cited by 9 publications

(10 citation statements)

References 280 publications

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“…Increased immune cell infiltration is another characteristic of the BBTB change . The disorganized and heterogeneous BBTB structure promotes leakage of blood products, a phenomenon known as the enhanced permeability and retention (EPR) effect, which is typical in many cancerous tissues . Overall, understanding the distinct properties of BBTB presents opportunities to develop strategies to safely and effectively overcome this barrier and improve drug delivery to brain tumors.…”

Section: Abnormal Bbb Structure In Cns Diseasesmentioning

confidence: 99%

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

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The blood−brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics. In this Review, first we introduce the anatomical structure and physiological functions of the BBB. Second, we present the endogenous and exogenous transport mechanisms by which NPs cross the BBB. We report various forms of nanomaterials, carriers, and their cargos, with their detailed BBB uptake and permeability characteristics. Third, we describe the effect of regulating the size, shape, charge, and surface ligands of NPs that affect their BBB permeability, which can be exploited to enhance and promote neurotheranostics. We classify typical functionalized nanomaterials developed for BBB crossing. Fourth, we provide a comprehensive review of the recent progress in developing functional polymeric nanomaterials for applications in multimodal bioimaging, therapeutics, and drug delivery. Finally, we conclude by discussing existing challenges, directions, and future perspectives in employing functionalized nanomaterials for BBB crossing.

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Section: Abnormal Bbb Structure In Cns Diseasesmentioning

confidence: 99%

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

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“…MSCs are versatile stem cells found in numerous tissues that have the ability to develop into different types of cells, such as osteoblasts, adipocytes, chondrocytes, and myofibroblasts. They are commonly employed in the fields of wound healing, chondrogenesis, and nerve regeneration ( 134 ). Due to their innate ability to specifically target tumors, MSCs can be utilized for the delivery of therapeutic medicines to tumor locations.…”

Section: Membrane Biomimetic Nanoparticlesmentioning

confidence: 99%

“…Due to their innate ability to specifically target tumors, MSCs can be utilized for the delivery of therapeutic medicines to tumor locations. Nevertheless, it is crucial to conduct thorough investigations to determine the exact function of MSCs in the formation of tumors in order to evaluate any potential hazards that they may provide, such as the emergence of metastasis ( 134 ). When comparing MSCs to MSCMs, it is pointed out that MSCMs provide a safer method for delivering drugs.…”

Section: Membrane Biomimetic Nanoparticlesmentioning

confidence: 99%

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Zhang,

Wang

2024

Front. Oncol.

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Early detection of cancer is crucial to reducing fatalities and improving patient outcomes. Metastasis is the first stage of aggressive cancers, often occurring before primary lesions can be seen. It occurs when cancerous cells disseminate to distant, non-malignant organs through the bloodstream, known as circulating tumor cells (CTCs). CTCs, or cancer tumor cells, are valuable indicators for predicting treatment response, metastasis progression, and disease progression. However, they are primarily used for research due to challenges like heterogeneity, separation from blood, and lack of clinical validation. Only a few methods have been approved for clinical use. One area of research is the isolation and identification of CTCs, which could significantly impact early cancer detection and prognosis. Current technologies using whole-blood samples use size, immunoaffinity, and density approaches, along with positive and negative enrichment techniques. Surface modification of nanomaterials is important for effective cancer therapies because it improves their ability to target and reduces interactions with healthy tissues. Consequently, researchers have created biomimetic nanoparticles covered with cell membranes using functional, targeted, and biocompatible coating technology. Nanoparticles with membranes can target specific cells, stay in circulation for longer, and avoid immune responses, which makes them much better at capturing CTCs. This study examines the current opportunities and difficulties associated with using cell membrane–coated nanoparticles as a capture technique for CTCs. In addition, we examine potential future developments in light of the current obstacles and investigate areas that require further research to fully understand its growing clinical possibilities.

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“…The potential of membrane hybridization technology to amalgamate functional proteins derived from diverse cellular membranes is tempered by the challenges associated with identifying a compatible fusion strategy for distinct membrane types [ 39 ]. Such impediments could precipitate the incorporation of extraneous molecules, with consequent deleterious responses.…”

Section: Strategies For Engineered Cell Membranesmentioning

confidence: 99%

Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications

Guan,

Xing,

Liu

2024

Nanomaterials

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Recent strides in nanomaterials science have paved the way for the creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering the integration of natural cell membranes into sophisticated nanocarrier architectures, cell membrane camouflage has emerged as a transformative approach for regulated drug delivery, offering the benefits of minimal immunogenicity coupled with active targeting capabilities. Nevertheless, the utility of nanomaterials with such camouflage is curtailed by challenges like suboptimal targeting precision and lackluster therapeutic efficacy. Tailored cell membrane engineering stands at the forefront of biomedicine, equipping nanoplatforms with the capacity to conduct more complex operations. This review commences with an examination of prevailing methodologies in cell membrane engineering, spotlighting strategies such as direct chemical modification, lipid insertion, membrane hybridization, metabolic glycan labeling, and genetic engineering. Following this, an evaluation of the unique attributes of various nanomaterials is presented, delivering an in-depth scrutiny of the substantial advancements and applications driven by cutting-edge engineered cell membrane camouflage. The discourse culminates by recapitulating the salient influence of engineered cell membrane camouflage within nanomaterial applications and prognosticates its seminal role in transformative healthcare technologies. It is envisaged that the insights offered herein will catalyze novel avenues for the innovation and refinement of engineered cell membrane camouflaged nanotechnologies.

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Lipid-hybrid cell-derived biomimetic functional materials: A state-of-the-art multifunctional weapon against tumors

Cited by 9 publications

References 280 publications

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications

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