Lipid-Induced Mechanisms of Metabolic Syndrome

Denisenko, Yulia K.; Kytikovа, O. Yu.; Новгородцева, Т. П.; Аntonyuk, M. V.; Gvozdenko, T. A.; Кантур, Т. А.

doi:10.1155/2020/5762395

Cited by 51 publications

(30 citation statements)

References 110 publications

(223 reference statements)

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“…Oxidative stress is associated with a wide range of diseases, such as diabetes mellitus and metabolic syndrome (including hyperlipidemia, hyperglycemia, hypertension, and obesity), which all of which are risk factors for cardiovascular diseases (Denisenko et al., 2020 ; Gil‐del Valle et al., 2005 ). To date, several studies have been carried out to evaluate the effect of saffron on different OS markers in these aforementioned diseases and others (Razavi & Hosseinzadeh, 2017 ; Pour et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials

Morvaridzadeh

Agah

Estêvão

et al. 2021

Food Science & Nutrition

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Section: Discussionmentioning

confidence: 99%

Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials

Morvaridzadeh

Agah

Estêvão

et al. 2021

Food Science & Nutrition

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“…Several lipid mediators are derived from the metabolism of PUFA such as AA, DHA, and eicosapentaenoic acid (EA, ω-3, 20:5). For instance, oxidation of AA to produce prostaglandins, thromboxanes, and leukotrienes are involved in pro-inflammatory response, while the metabolism of AA to yield lipoxins, and that of DHA and EA to yield resolvins, protectins, and maresins are involved in the anti-inflammatory response ( Denisenko et al, 2020 ). These PUFA are essential fatty acids and need to be obtained through diet.…”

Section: Chronic Inflammation and Plasmalogenmentioning

confidence: 99%

Plasmalogens and Chronic Inflammatory Diseases

2021

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It is becoming widely acknowledged that lipids play key roles in cellular function, regulating a variety of biological processes. Lately, a subclass of glycerophospholipids, namely plasmalogens, has received increased attention due to their association with several degenerative and metabolic disorders as well as aging. All these pathophysiological conditions involve chronic inflammatory processes, which have been linked with decreased levels of plasmalogens. Currently, there is a lack of full understanding of the molecular mechanisms governing the association of plasmalogens with inflammation. However, it has been shown that in inflammatory processes, plasmalogens could trigger either an anti- or pro-inflammation response. While the anti-inflammatory response seems to be linked to the entire plasmalogen molecule, its pro-inflammatory response seems to be associated with plasmalogen hydrolysis, i.e., the release of arachidonic acid, which, in turn, serves as a precursor to produce pro-inflammatory lipid mediators. Moreover, as plasmalogens comprise a large fraction of the total lipids in humans, changes in their levels have been shown to change membrane properties and, therefore, signaling pathways involved in the inflammatory cascade. Restoring plasmalogen levels by use of plasmalogen replacement therapy has been shown to be a successful anti-inflammatory strategy as well as ameliorating several pathological hallmarks of these diseases. The purpose of this review is to highlight the emerging role of plasmalogens in chronic inflammatory disorders as well as the promising role of plasmalogen replacement therapy in the treatment of these pathologies.

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“…Furthermore, several cross-sectional studies have linked NAFLD to diabetes and MS suggesting NAFLD precedes the development of these conditions Lonardo et al (2015) . Lipids play crucial roles in the pathogenesis of various metabolic conditions such as NAFLD, insulin resistance and MS Denisenko et al (2020) . Accumulated evidence suggests that different FAs play specific roles depending on their carbon length, degree of saturation, chain conformation and whether they are an even or odd chain FA Zhou et al (2020) .…”

Section: Introductionmentioning

confidence: 99%

Regulation of odd chain fatty acid metabolism in the development of metabolic diseases in mice fed a low protein diet

Ampong

2022

Preprint

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Nonalcoholic fatty liver disease (NAFLD) and Metabolic syndrome (MS) have become a global health concern as incidence of these metabolic disorders is growing rapidly in developing countries particularly in the Middle East, South America and Africa. Studies have shown that protein restriction is associated with increased risk of metabolic diseases, possibly through effects on fatty acid (FA) metabolism. In the present study, we investigated whether a low protein diet modulates FA metabolism and whether methyl donor supplementation can ameliorate these effects and improve metabolic health. Male C57BL/6 mice were fed either a low protein diet (LPD, 90 g/kg protein, n=8), a LPD supplemented with methyl donors (MD-LPD; choline chloride, betaine, methionine, folic acid, vitamin B12, n=8) or normal protein diet (NPD, 180 g/kg protein, n=8) for 7 weeks prior to analysis of serum fatty acid profiles by GC FID and MS and liver fatty acid synthesis and uptake gene expression by RT-qPCR. We observed significant depletion of serum C15:0 and C17:0 in LPD-fed males compared to NPD. Serum long chain saturated FAs C18:0 and C24:0 were increased in LPD male mice compared to NPD. Gene expression analysis revealed an upregulation of hepatic cluster of differentiation 36 (CD36) expression in LPD mice compared to NPD suggesting increased fat uptake in the liver. However, when LPD diet was supplemented with methyl donors, we observed either no change in serum C15: 0 and an increased serum C17:0 compared to LPD with no methyl donor supplementation. Again, methyl donor supplementation upregulated fatty acid desaturase 1 (FADS1), thioredoxin-1 (TRX1) and catalase (CAT) expression in the liver of MD-LPD fed mice compared to LPD mice. Altogether, our study revealed that odd chain fatty acids (OCFA)s are key early markers observed in a suboptimal diet-induced metabolic changes and may be potential targets to improve metabolic health outcomes.

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Lipid-Induced Mechanisms of Metabolic Syndrome

Cited by 51 publications

References 110 publications

Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials

Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials

Plasmalogens and Chronic Inflammatory Diseases

Regulation of odd chain fatty acid metabolism in the development of metabolic diseases in mice fed a low protein diet

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