Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity

Banerjee, Dipanjan; Patra, Debarun; Sinha, Archana; Roy, Soumyajit; Pant, Rajat; Sarmah, Raktim; Dutta, Rajdeep; Bhagabati, Sarada Kanta; Tikoo, Kulbhushan; Pal, Durba; Dasgupta, Suman

doi:10.1007/s00018-022-04306-1

Cited by 8 publications

(3 citation statements)

References 68 publications

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“…The differentiation of 3T3-L1 cells into adipocytes was further confirmed by performing oil-red O staining and imaging following the protocol described earlier ( 44 ). Briefly, adipocytes were fixed in a solution containing 4% formaldehyde for a duration of 10 min.…”

Section: Methodsmentioning

confidence: 99%

Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity

Patra,

Ramprasad,

Sharma

et al. 2024

Journal of Biological Chemistry

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Section: Methodsmentioning

confidence: 99%

Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity

Patra,

Ramprasad,

Sharma

et al. 2024

Journal of Biological Chemistry

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“…CypA activates the surface receptor CD147, thereby activating NF-κB signaling, which increases the expression of pro-inflammatory cytokines, inducing adipocyte inflammation. Simultaneously, it hinders adipocyte differentiation by suppressing the expression of PPARγ and C/EBPβ through leucine zipper tumor suppressor 2 (LZTS2) mediated downregulation of β-catenin [263,264]. These findings suggest that CypA may attenuate adipose tissue function and improve insulin sensitivity.…”

Section: Cypamentioning

confidence: 99%

“…However, other studies suggest that CypA-CD147 interaction mediates obesity-induced macrophage-adipocyte crosstalk and, thus, may represent a novel target for the treatment of insulin resistance and type 2 diabetes [263]. CypA activates the surface receptor CD147, thereby activating NF-κB signaling, which increases the expression of pro-inflammatory cytokines, inducing adipocyte inflammation.…”

Section: Cypamentioning

confidence: 99%

Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated

Kim,

Lee,

et al. 2023

Nutrients

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Endoplasmic reticulum (ER) stress plays a pivotal role in adipogenesis, which encompasses the differentiation of adipocytes and lipid accumulation. Sustained ER stress has the potential to disrupt the signaling of the unfolded protein response (UPR), thereby influencing adipogenesis. This comprehensive review illuminates the molecular mechanisms that underpin the interplay between ER stress and adipogenesis. We delve into the dysregulation of UPR pathways, namely, IRE1-XBP1, PERK and ATF6 in relation to adipocyte differentiation, lipid metabolism, and tissue inflammation. Moreover, we scrutinize how ER stress impacts key adipogenic transcription factors such as proliferator-activated receptor γ (PPARγ) and CCAAT-enhancer-binding proteins (C/EBPs) along with their interaction with other signaling pathways. The cellular ramifications include alterations in lipid metabolism, dysregulation of adipokines, and aged adipose tissue inflammation. We also discuss the potential roles the molecular chaperones cyclophilin A and cyclophilin B play in adipogenesis. By shedding light on the intricate relationship between ER stress and adipogenesis, this review paves the way for devising innovative therapeutic interventions.

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A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo

Choudhary

Patra

Sinha

et al. 2023

European Journal of Pharmacology

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Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity

Cited by 8 publications

References 68 publications

Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity

Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity

Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated

A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo

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