Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents

Dupuy, Anne‐Marie; Carrière, Isabelle; Scali, Jacqueline; Cristol, Jean‐Paul; Ritchie, Karen; Dartigues, Jean‐François; Gambert, Philippe; Ancelin, Marie-Laure

doi:10.1080/13697130701877108

Cited by 16 publications

(5 citation statements)

References 40 publications

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“…This gender difference may be related to different hormonal status. Estrogen which could modify the cholesterol metabolic process was lower in postmenopausal women [39]. Animal study has suggested sex differences linked to a difference in LDL receptor [40].…”

Section: Discussionmentioning

confidence: 99%

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi’an, China

Zhao

Shang

et al. 2019

Lipids Health Dis

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BackgroundSerum lipids [total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)] are risk factors for stroke, but the relationships between serum lipids and cognitive impairment have not been verified completely. In this study, we studied the relationships between serum lipids and cognitive impairment and explored whether gender and age had effects on the relationships.MethodsIn this cross-sectional study, we collected serum lipids and cognitive function information from 1762 participants (aged 40–85). Univariate analysis, multivariate analysis, and both gender- and age-based stratified multivariate analysis were used.ResultsIn the entire sample set, there was no significant correlation between serum lipid parameters (TC, LDL-C, HDL-C and TG) and cognitive impairment. In both gender- and age-based stratified multivariate analysis, high serum TC was positively associated with cognitive impairment in the elderly (> 55) male participants (OR = 4.404, 95% CI = 1.264–15.344, p = 0.02), and high serum LDL-C was positively correlated with cognitive impairment in the elderly female subjects (OR = 2.496, 95% CI = 1.057–5.896, p = 0.037), while high serum TG was negatively associated with cognitive impairment in the middle-aged (≤ 55) male participants (OR = 0.157, 95% CI = 0.051–0.484, p = 0.001).ConclusionsThe relationships between serum lipids and cognitive impairment are gender- and age- dependent, with high serum TC and LDL-C may be risk factors of cognitive impairment in the elderly male and female subjects respectively, while high serum TG may be protector of cognitive impairment in the middle-aged male participants.

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Section: Discussionmentioning

confidence: 99%

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi’an, China

Zhao

Shang

et al. 2019

Lipids Health Dis

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“…Previous studies of dyslipidemia in primary care in France have either focused on LDL-C and/or TC22–24 or have reported values for individual lipids (TC and triglycerides;25 LDL-C, HDL-C, and triglycerides26) according to NCEP ATP III guidelines 25,26. Studies of mixed dyslipidemias in European countries have applied NCEP ATP III guidelines27 or modified JES III guidelines 28.…”

Section: Introductionmentioning

confidence: 99%

Mixed dyslipidemias in primary care patients in France

Laforest¹,

Ambegaonkar²,

Souchet³

et al. 2012

VHRM

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ObjectiveTo determine the prevalence of single and mixed dyslipidemias among patients treated with statins in clinical practice in France.MethodsThis is a prospective, observational, cross-sectional, pharmacoepidemiologic study with a total of 2544 consecutive patients treated with a statin for at least 6 months.Main outcome measuresPrevalence of isolated and mixed dyslipidemias of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides among all patients and among patients at high cardiovascular risk; clinical variables associated with attainment of lipid targets/normal levels in French national guidelines.ResultsAt least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients. Dyslipidemias of LDL-C, HDL-C, and triglycerides were present in 27.7%, 12.4%, and 28.7% of all patients, respectively, and in 51.0%, 18.2%, and 32.5% of high-risk patients, respectively. Among all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%. Age, gender, body mass index and Framingham Risk Score >20% were the factors significantly associated with attainment of normal levels for ≥2 lipid levels.ConclusionsAt least one dyslipidemia persisted in half of all patients and two-thirds of high cardiovascular risk patients treated with a statin. Dyslipidemias of HDL-C and/or triglycerides were as prevalent as elevated LDL-C among high cardiovascular risk patients.

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“…LDL-C was determined by the Friedwald formula (22). Genotyping of ApoE and 5-HTTLPR was performed as described previously (23).…”

Section: Socio-demographic and Clinical Variablesmentioning

confidence: 99%

Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study)

Ancelin

Carrière

Boulenger

et al. 2010

Biological Psychiatry

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Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents

Cited by 16 publications

References 40 publications

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi’an, China

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi’an, China

Mixed dyslipidemias in primary care patients in France

Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study)

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