Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study

Harrison, Stephanie L; Lane, Deirdre A.; Banach, Maciej; Mastej, Mirosław; Lip, Gregory Y.H.; Al-Shaer, B.; Andrusewicz, W; Andrzejczuk-Rosa, M.; Anusz-Gaszewska, E.; Baginska, Anna; Balawajder, P.; Banka, Gaurav; Barańska-Skubisz, E.; Przyczyna, B. Barbara; Bartkowiak, Susan; Bartodziej, Jarosław; Bartosiewicz, Małgorzata; Basałyga, M.; Batyra, A.; Bak, Annette; Bednarz, Mark S.; Bejnar, K.; Bernacki, W.; Betiuk-Kwiatkowska, M.; Biegaj, S.; Bien, Mauo Ying; Bilski, W.; Biłogan, M.; Biruta-Pawłowska, G.; Biskup, A.; Błaszczyk, Barbara; Błaszczyk, H.; Błońska-Jankowska, T.; Bogacka-Gancarczyk, B.; Bojanowska, Marzena; Bonda, Elżbieta; Borowik-Skwarek, J.; Borowska, J; Bruckner, James V.; Brzostek, Jerzy; Brzuchacz, M.; Budzyńska, M.; Bulzacka-Fugiel, I.; Bulzak, J.; Bunikowski, K.; Cebulska, A.; Celka, T.; Cempel-Nowak, E.; Chechliński, W; Chludzińska, A.; Chmiel, D.; Chmielewska, Magdalena; Cichy, M.; Ciemięga, A.; Ciepluch, A.; Cieszyńska, I.; Czajka, Beata; Czapla, Beata; Czerner, M.; Czerwińska, B; Czuryszkiewicz, W; Daleka, E.; Dawid, Z.; Dąbrowska, Magdalena; Da̧browska, Renata; Dąbrowski, Dariusz; Dąbrowski, M; Demczyszyn, K.; Dębowska-Serwińska, A.; Dmochowski, Jacek; Dobrzecka-Kiwior, J.; Dolanowska, E.; Dolanowski, H.; Dołek, P.; Domagała, Michał; Domański, Henryk; Doszel, A.; Duda, D.; Dudkowska, Magdalena; Dudziuk, B.; Dybciak, P.; Dymanowski, M.; Dziadzio-Bolek, L.; Eicke, Martin; Elhassan, Huda H M; Eremus, A.; Fąferek-Muller, M.; Figura-Roguska, E.; Fijałkowska-Kaczmarek, I.; Flis, Marta; Florczak, T.; Florczuk, Mateusz; Foryszewska-Witan, E.; Frydrych, W.; Fugiel, Andrzej; Futyma, E.; Gaca-Jaroszewicz, A.; Gajdamowicz, I.; Ganczarski, K.; Gatnar, Aleksander; Gers, M.; Głowacki, Andrzej; Głód, K.; Godula, J; Gołąb, J.; Golebiewski, Matthew; Goszczyńska, Ewa; Gościcka, Katarzyna; Górna-Hajduga, A.; Górny, E.; Grabowska, T.; Grabowski, R; Graczyk-Duda, A.; Gromow, A.; Grudewicz, A.; Gruszecka, Jolanta; Gruszka, Agata; Gryboś, J.; Grzebyk, J; Grzechowiak, A.; Grzesiak, D.; Grześkowiak, T.; Guźla, A.; Hachuła, G.; Hawel, B.; Hiltawska, H.; Honkowicz, E.; Ignatowicz, J.; Imielski, K.; Iwaniura, A.; Jagieła-Szymala, A.; Jalć-Sowała, M.; Janczylik, A.; Janisz, E.; Janiszek, M.; Jankiewicz-Ziobro, K; Januszewska, Katarzyna; Jaremek, A.; Jaros-Urbaniak, A.; Jarosz, Józef; Jarosz, Piotr Michał; Jasinski, W; Jezierska-Wasilewska, M.; Jędraszewski, T.; Jedrzejowska, Anna Sysa; Józefowicz, Ralph F.; Jóźwiak, Jacek Jerzy; Juźwin, K; Kacprzak, E.; Kaczmarek-Szewczyk, J.; Kaczmarzyk, M; Kandziora, R.; Kaniewski, C.; Karolak-Brandt, L.; Kasperczyk, Sławomir; Kasperek-Dyląg, E.; Kedziora, I.; Kępa, A.; Kiciński, J; Kielak-Al-Hosam, J.; Kiełczawa, Ł.; Kilimowicz, P.; Kitliński, K.; Kiwka, T.; Klein, U.; Klichowicz, L.; Klimowicz, Aleksandra; Klonowski, B.; Kmolek, B.; Kobyłko-Klepacka, E.; Kocoń, A.; Kolenda, A.; Kollek, E.; Kopeć, M; Koper-Kozikowska, B.; Koralewska, J; Korczyńska, M.; Korzeniewski, M.T.; Kosk, A.; Kotarski, K; Kowalczyk, Edward; Kowalczyk, Monika; Kowalik, Ilona; Kozak-Błażkiewicz, B.; Kozik, M; Kozlowska, D; Kozłowska, Elżbieta; Kozłowska, Marta; Kozubski, T.; Kózka, K.; Kraśnik, Leonard; Krezel, T; Krochmal, B; Krol, Bernardo; Król, Grzegorz Bojarski i Anna; Król, J; Królikowska, T.; Kruszewska, H.; Krygier-Potrykus, B; Krystek, W.; Krzysztoń, Janusz; Kubicki, T.; Kuczmierczyk-El-Hassan, A.; Kuczyńska-Witek, W.; Kujda, D.; Kurowski, Andrzej; Kurzelewska-Solarz, I.; Kwaczyńska, M.; Kwaśniak, Małgorzata; Kwaśniak, P.; Kwietniewska, T.; Łebek-Ordon, A.; Lebiedowicz, A.; Lejkowska-Olszewska, L.; Lentas, M.; Lesiewicz-Ksycińska, A.; Limanowski, M.; Łoniewski, S.; Łopata, J A; Łubianka, B.; Łukasiuk, I.; Łużna, M.; Łysiak, M; Łysik, B; Machowski, Z; Maciaczyk-Kubiak, J.; Mackiewicz-Zabochnicka, G.; Magner-Krężel, Z; Majda, S.; Malinowski, Paige; Mantyka, J.; Marchlik, Erica; Martyna-Ordyniec, G.; Marzec, Jacqui; Marzec, Maria; Matejko-Wałkiewicz, R.; Mazur, Marta; Michalczak, Magdalena; Michalska-Żyłka, A.; Michniewicz, M.; Mika-Staniszewska, D.; Mikiciuk, E.; Mikołajczak, T.; Milewski, Janusz; Miller, Edward B.; Misiaszek, Brian; Mizik-Łukowska, M.; Młyńczyk-Pokutycka, E.; Mocek, M.; Moczała, M.; Morawska-Hermanowicz, M.; Moryc, P.; Moskal, Adrian; Moskal, S.; Moździerz, Aleksandra; Moździerz, P.; Mrozińska, M.; Mrozowicz, K.; Mróz, G.; Munia, T.; Mura, Aleksandra; Muras-Skudlarska, M.; Murawska, E.Z.; Murawski, Ł.; Murawski, Robert; Musielak, R.; Nadaj, K.; Nagarnowicz, W; Napierala, Randal; Niedźwiecka, Marta; Niemirski, A; Nikiel, J.; Nosál, Matej; Nowacki, Wojciech; Nowak, Jolanta; Nyrka, M.; Obst, Anne; Ochowicz, J.; Ogonowska, E.; Oleszczyk, M.; Ołdakowski, A.; Ołowniuk-Stefaniak, I.; Ordowska-Rejman, J.; Orliński, M.; Osińska, B; Ostańska-Burian, A.; Paciorkowska, A.; Paczkowska, U.; Paluch, Łukasz; Pałka, L.; Paszko-Wojtkowska, J.; Paszkowska, A; Pawlak-Ganczarska, E.; Pawlik, Wiesław W.; Pawlowska, Izabela; Paździora, M.; Permiakow, G.; Petlic-Marendziak, A.; Piasecka, T.; Piaścińska, E.; Piktel, A.; Pilarska-Igielska, A.; Piotrkowska, A.; Piwowar-Klag, K; Planer, M.; Plewa, J.; Płatkiewicz, P.; Płonczyńska, B.; Podgórska, Anna; Polewska, M.; Porębska, B.; Porwoł, P.; Potakowska, I.; Prokop, A; Przybylski, Jacek; Przybyła, Monika; Psiuk, H.; Ptak, Krzysztof; Puzoń, G.; Rabiza, N.; Rachwalik, S.; Raczyńska, E.; Raniszewska, M.; Romanek-Kozik, A.; Rosa, Antonio Manuel Sánchez de la; Rosa, Kaleizu Teodoro; Rozewicz, A.; Rudzka-Kałwak, J.; Rusak, J; Rutkowska, D.; Rybacki, Marcin; Rybińska, D.; Rycyk-Sadowska, A.; Rynda, L.; Rynkiewicz, B.; Sadowska-Krawczyk, B.; Sadowska-Zarzycka, M.; Sarnecka, B.; Sawalach-Tomanik, E.; Sidor-Drozd, B.; Siemieniak-Dębska, M.; Sieroń, Aleksander; Siewniak-Zalewska, B.; Sikora, Alex; Sitarska-Pawlina, B.; Skorupski, Josh; Skrzypińska-Mansfeld, I.; Skubisz, J.; Skwarek, R.; Słodyczka, M.; Smentek, M.; Smolińska, K; Solarz, B; Weronika, SOSNOWSKA,; Sroka, B; Stachura, H.; Stangreciak, D.; Staniak, M.; Stańczyk, Z.; Stańszczak-Ozga, D.; Startek, E.; Stefańczyk, Marta; Stelmach, Rafaël; Sternadel-Rączka, E.; Sternik, M.; Stepien, Jacqueline M; Stocka, J; Stokowska-Wojda, M.; Studler-Karpińska, M.; Suchorukow, W; Sufryd, W.; Supłacz, B.; Sygacz, J; Szczepański, L; Szkandera, Joanna; Szłapa-Zellner, J; Szydlarska, D.; Śliwa, Tomasz; Śliwka, Joanna; Śmiejkowski, Ł.; Targońska, A.; Tesarska, E.; Tobiasz, M; Tomaka, Joe; Tomalska-Bywalec, K.; Tomiak, Eva; Topczewski, S.; Trawińska, A.; Trela-Mucha, L.; Trojanowski, D.; Trzaskowska, M.; Trzcińska-Larska, B.; Trznadel-Mozul, A.; Ulanicka-Liwoch, K; Urbanowicz, María; Uthke-Kluzek, A.; Waczyński, J.; Walczak, J; Warsz, L.; Wasyńczuk, M.; Wąchała-Jędras, U.; Wasowicz, Dareczka K.; Wczysła, J.; Wenda, F.; Werner-Kubicka, E.; Weryszko, E.; Węgrzynowska, B.; Wiaksa, M.; Wiankowski, M.; Wicherek, A.; Wieczorek, Ryszard; Wiencek, Robert G.; Wienzek-Tatara, G.; Wierzbicka, B; Wierzbicki, Mark A.; Wilczyńska, Barbara; Wilmańska, Dorota; Winiarski, Paweł; Wiszniewska-Pabiszczak, A.; Witkowska, Magdalena; Witzling, J.; Wlaź, A.; Wojtkowiak, I.; Woydyłło, J; Woźniak, Kamila; Wójtowicz, Anna; Wrona, Julia; Wronska, Malgorzata; Wujkowska, H.; Wyrąbek, J.; Wysokiński, O.; Zakrzewski, R.; Zaleska-Zatkalik, J.; Zaleski, Jan; Dybciak, M. Zalewska-; Zalewska, Elżbieta; Zalewska-Uchimiak, B.; Zawadzka-Krajewska, J; Zawadzki, Jacek; Zieliñski, Aleksander; Zubrycka, E.; Żybort, I.; Żymełka, M.

doi:10.1016/j.atherosclerosis.2020.08.026

Cited by 32 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with AA in our study needed lesser ACEI/ARBs and β-blockers probably due to limitations of renal and heart functions. We also found lower LDL, which was consistent with a previous study [ 31 ], as well as total cholesterol and body weight, in AA patients. Of all the factors that were significantly different between the AA and non-AA groups, only TSP-1, Hs-CRP, and age were found statistically significant by multivariate logistic regression analysis in our predictive model, which suggests a possibly stronger relationship between the incidence of AA and inflammation as well asage.…”

Section: Discussionsupporting

confidence: 93%

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Liao

Pan

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR 1.033; 95% CI 1.003–1.065, p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstract

show abstract

Section: Discussionsupporting

confidence: 93%

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Liao

Pan

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Patients with AA in our study needed lesser ACEI/ARBs and β-blockers probably due to limitations of renal and heart functions. We also found lower LDL, which was consistent with a previous study [29], as well as total cholesterol and body weight, in AA patients. Of all the factors that were significantly different between the AA and non-AA groups, only TSP-1, Hs-CRP, and age were found statistically significant by multivariate logistic regression analysis in our predictive model, which suggests a possibly stronger relationship between the incidence of AA and inflammation and age.…”

Section: Baseline Characteristics Of Ami Patientssupporting

confidence: 93%

Association of Atrial Arrhythmias With Thrombospondin-1 in Patients With Acute Myocardial Infarction

Liao

Pan

et al. 2021

Preprint

View full text Add to dashboard Cite

Objectives: Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods: A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results: Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR, 1.033; 95% CI, 1.003–1.065, p = 0.034), Hs-CRP (OR, 1.023; 95% CI, 1.006–1.041, p = 0.008), age (OR, 1.067; 95% CI, 1.004–1.135, p = 0.038) and LVDd (OR, 1.142; 95% CI, 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion: TSP-1 is a potential novel indicator of atrial arrhythmias during AMI.

show abstract

“…Similarly, longitudinal population data from the Czech Republic showed that statins were the most commonly prescribed regimen, with 79% of patients receiving statins in recent years [28]. Despite the availability of statins, recently published studies focusing on individual countries in CEE have highlighted the significant burden of dyslipidaemia in this region and the need for further action to achieve optimal LDL-C levels in CEE [29][30][31][32][33]. The LIPIDOGRAM studies are the largest population-based surveys assessing the prevalence of dyslipidaemia in Poland, which demonstrated that the number of patients with dyslipidaemia in Poland remains high [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the availability of statins, recently published studies focusing on individual countries in CEE have highlighted the significant burden of dyslipidaemia in this region and the need for further action to achieve optimal LDL-C levels in CEE [29][30][31][32][33]. The LIPIDOGRAM studies are the largest population-based surveys assessing the prevalence of dyslipidaemia in Poland, which demonstrated that the number of patients with dyslipidaemia in Poland remains high [29][30][31]. CV risk factors have also been shown to be elevated among Polish primary care patients.…”

Section: Discussionmentioning

confidence: 99%

Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background and aims: Central and Eastern Europe (CEE) is a largely understudied region, despite having the highest cardiovascular disease mortality in Europe. This analysis aimed to assess the proportion of patients in CEE who achieved their LDL-C goals based on individual cardiovascular risk recommended by the 2016 and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines. Methods: The DA VINCI study was a cross-sectional observational study of primary and secondary prevention patients receiving lipid-lowering therapy across Europe between June 2017 and November 2018. Results: In total, 2154 patients were enrolled from the Czech Republic (n = 509), Hungary (n = 319), Poland (n = 460), Romania (n = 259), Slovakia (n = 123) and Ukraine (n = 484). At LDL-C measurement, most patients were on either moderate-or high-intensity statin monotherapy (53% and 32%, respectively). Despite this, only 44% of patients achieved risk-based LDL-C goals recommended by the 2016 ESC/EAS guidelines, ranging from 21% in Ukraine to 50% in Hungary and Romania. Only 24% of patients overall achieved the risk-based LDL-C goals recommended by the 2019 ESC/EAS guidelines, ranging from 11% in Ukraine to 32% in Poland. Conclusions: Among patients receiving lipid-lowering therapy, more than half did not achieve their 2016 LDL-C goals. In one of the first comparative analyses evaluating 2019 risk-based goal attainment among countries in CEE, three-quarters of patients did not meet their 2019 LDL-C goals, highlighting a significant gap between guidelines and clinical practice for lipid management in CEE.

show abstract

Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study

Cited by 32 publications

References 35 publications

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Association of Atrial Arrhythmias With Thrombospondin-1 in Patients With Acute Myocardial Infarction

Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study

Contact Info

Product

Resources

About