Lipid Levels in Serum, Liver and Aorta of the
Vervet Monkey

Kritchevsky, David; Davidson, Larry M.; Kim, Hong; Winter, P.A.D.

doi:10.1159/000460327

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…As introduced above, NAFLD, along with its sequelae, including nonalcoholic steatohepatitis (NASH), has emerged as the most prevalent liver disease, and new approaches for managing NAFLD and NASH are needed. As far back as the mid-1970s it was noted that NHPs, like humans, were susceptible to the accumulation of excess lipids in the liver (Kritchevsky et al 1973). More recently, however, studies in a number of NHP species have focused specifically on the pathogenesis of NAFLD and NASH (Bose et al 2010;Cydylo et al 2017;Kamath et al 2011;Kavanagh et al 2013;Nagarajan et al 2008).…”

Section: Fatty Liver Diseasementioning

confidence: 99%

Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field

et al. 2017

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Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease, and fatty liver disease, are becoming increasingly widespread in both the developed and developing world. There is an urgent need to identify new approaches for the prevention and treatment of these costly and prevalent metabolic conditions. Accomplishing this will require the use of appropriate animal models for preclinical and translational investigations in metabolic disease research. Although studies in rodent models are often useful for target/pathway identification and testing hypotheses, there are important differences in metabolic physiology between rodents and primates, and experimental findings in rodent models have often failed to be successfully translated into new, clinically useful therapeutic modalities in humans. Nonhuman primates represent a valuable and physiologically relevant model that serve as a critical translational bridge between basic studies performed in rodent models and clinical studies in humans. The purpose of this review is to evaluate the evidence, including a number of specific examples, in support of the use of nonhuman primate models in metabolic disease research, as well as some of the disadvantages and limitations involved in the use of nonhuman primates. The evidence taken as a whole indicates that nonhuman primates are and will remain an indispensable resource for evaluating the efficacy and safety of novel therapeutic strategies targeting clinically important metabolic diseases, including dyslipidemia and atherosclerosis, type 2 diabetes, hepatic steatosis, steatohepatitis, and hepatic fibrosis, and potentially the cognitive decline and dementia associated with metabolic dysfunction, prior to taking these therapies into clinical trials in humans.

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Section: Fatty Liver Diseasementioning

confidence: 99%

Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field

et al. 2017

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Total Fatty Acids of Various Mammalian Organs Nonparametric Statistical Correlations

Gershbein

Baburao

1981

Fette, Seifen, Anstrichm.

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konnen jedoch dann keine Einwande erhoben werden, wenn sich die Erzeugnisse von vergleichbaren deutlich in ihren Eigenschaften oder in der Zusammensetzung unterscheiden. Die hervorhebende Angabe ist aber an eine Verkehrsbezeichnung gebunden, aus der eindeutig zu erkennen ist, dai3 gehartete Erzeugnisse vorliegen. Da bei zubereiteten Lebensmitteln ein Hinweis auf die Verwendung von geharteten Fetten nicht gefordert wird, sind hervorhebende Qualitatshinweise nur dann vertret-bar, wenn das gehartete Speisefett besonders herausgestellt wird oder wenn sich die Hervorhebung auf das gesamte Lebensmittel bezieht. Allerdings sollten bei Verarbeitung von geharteten Speisefetten, unabhangig von der Art und Beschaffenheit, qualitatsbezeichnende Herausstellungen uber ,,fein" oder ahnlich nicht hinausgehen.

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