Lipid Levels Including Oxidized LDL in Women with History of Preeclampsia

Abstract

Preeclampsia (PE), a leading cause of maternal and perinatal morbidity and mortality worldwide, is a hypertensive disorder of unknown aetiology characterized by proteinuria, coagulation abnormalities and different systemic manifestations. Since there are no studies regarding the evaluation of oxidized LDL (oxLDL) in women with a history of PE, we focused on the evaluation of lipid profile and oxLDL plasma concentration several years after pregnancy to see if these women have any modifications in these parameters that may be linked to the risk of cardiovascular disease (CVD) in the future. Ninety women with a history of PE and 60 controls in a median interval of 6 years after pregnancy were recruited. Plasma oxLDL levels were measured using a two-site enzyme immunoassay. Concentration of cholesterol, triglycerides (TG), HDL-cholesterol (HDLc) and LDL-cholesterol (LDLc) were measured by automated enzymatic assays. To evaluate apoA and apoB levels automated immunoturbidimetric assays were used. In the group of women with a history of PE, gestational age at delivery was significantly earlier in comparison with the control group, whereas birth weight was significantly lower and there were more caesarean sections. Systolic and diastolic blood pressures were significantly higher in women with a history of PE than in the control group. Significantly higher obesity anthropometric markers (BMI and waist-to-hip ratio) were found in women with a history of PE. As consistent with other authors' findings, blood pressure was higher in these women, but lipid profile did not seem to play a role in the increased risk of cardiovascular disease.

The association between preeclampsia and arterial stiffness

“…These discrepancies may stem from the differences in the severity of preeclampsia, and the time elapsed since preeclampsia between the four studies. Some studies have found an increased level of highdensity lipoprotein and triglycerides [81,82], whereas others have reported similar levels of plasma lipids as compared with controls [83,84]. Further research is needed in this area.…”

Preventing cardiovascular disease after hypertensive disorders of pregnancy: Searching for the how and when

“…Weighted mean values for HDL-C and LDL-C are displayed in Figure 3(c) and ( d ). 35 , 71 , 72 , 74 , 80 , 81 , 84 , 89 , 91 , 95 , 99 – 103 , 106 – 111 , 113 , 114 , 117 – 119 The large standard deviation for mean HDL-C in the 10-year post-partum group is because this category yields only one study. 89 …”

“…68,69 When two manuscripts were published on the same cohort, the oldest was excluded. 70–72

Figure 1.Flowchart (last search 20 October 2015). HDP: hypertensive disorder during pregnancy

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Waist hip ratio in early pregnancy as a clinical indicator of serum lipid levels and predictor of pregnancy complications

“…10 Similarly, Portelinha et al reported an association between obesity anthropometric markers (BMI and WHR) in women with a history of pre eclampsia. 11 Significantly raised levels of VLDL were reported in patients who developed preeclampsia in a study by Kumari et al 12 Though in the present study, the WHR showed a strong positive correlation with the BMI, it is worth noting that mean BMI of the subgroup of women with WHR>0.80 (mean BMI 21.1 Kg/m 2 ; range 18-25Kg/m 2 ; SD±1.5), was in the normal range for Indian population i.e. <23Kg/m 2 .…”