Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat—The HELENA Study

Spinneker, André; Egert, Sarah; González‐Gross, Marcela; Breidenassel, Christina; Albers, Ulrike; Stoffel‐Wagner, Birgit; Huybrechts, Inge; Μanios, Yannis; Venneria, Eugenia; Molnár, Denés; Widhalm, Kurt; Moreno, Luís A.; Stehle, Peter

doi:10.1038/ejcn.2011.222

Cited by 24 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin E is transported in circulation by plasma lipoproteins mainly LDL and HDL [ 23 , 24 ]. Mean cholesterol values reported in this study were closed to those reported in European children and adolescents in the HELENA and IDEFICS studies [ 25 , 26 ] and slightly lower than those reported among French children [ 27 – 29 ]. Since α-tocopherol is known to increase with the degree of hyperlipidemia and is dependent on lipid metabolism for delivery to tissues, adjustment for total cholesterol or lipids is also important to assess vitamin E status in some special conditions such as cholestasis or cystic fibrosis [ 24 , 30 ].…”

Section: Discussioncontrasting

confidence: 83%

Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia

Cuerq

Restier

Drai

et al. 2016

Orphanet J Rare Dis

View full text Add to dashboard Cite

BackgroundChylomicron retention disease (CMRD), a rare genetic hypocholesterolemia, results in neuro-ophtalmologic damages, which can be prevented by high doses of vitamin E during infancy. In these patients, plasma vitamin E concentration is significantly reduced due to defects of chylomicron secretion. Vitamin E in adipose tissue (AT) and red blood cells (RBC) have been proposed as potential relevant biomarkers of vitamin E status but no reference values in children are available. The objectives were (i) to establish age-reference intervals in healthy children for α-tocopherol in plasma, red blood cells (RBC) and adipose tissue (AT) and (ii) to determine the variations of α-tocopherol in patients with CMRD after oral treatment with vitamin E.MethodsThis prospective study included 166 healthy children (1 month - 18 years) and 4 patients with CMRD. Blood and AT were collected in healthy children during a scheduled surgery and in patients before and after a 4-month treatment with α-tocopherol acetate.ResultsThe reference ranges for α-tocopherol were 11.9 - 30 μmol/L in plasma, 2.0 - 7.8 μmol/L packed cells in RBC and 60 - 573 nmol/g in AT. α-tocopherol levels in plasma correlated with those of RBC (r = 0.31; p < 0.01).In patients with CMRD after 4 months treatment, α-tocopherol concentrations remained less than 70 % of the control values in plasma, increased by 180 % to reach normal values in RBC, and remained stable in the normal range in AT.ConclusionThis study establishes pediatric reference intervals for α-tocopherol in plasma, RBC and AT. These values will be beneficial in assessing accurate α-tocopherol status in children and to optimize the monitoring of rare diseases such as CMRD. Our data suggest that RBC α-tocopherol, appears as a relevant biomarker to appreciate the effectiveness of treatment with α-tocopherol in patients with a rare primary hypocholesterolemia. The biopsy of AT could be used at diagnosis to assess the severity of the vitamin E deficiency and periodically after a long duration of vitamin E therapy to assess whether the treatment is effective, based on reference intervals defined in this study.

show abstract

Section: Discussioncontrasting

confidence: 83%

Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia

Cuerq

Restier

Drai

et al. 2016

Orphanet J Rare Dis

View full text Add to dashboard Cite

show abstract

“…It has been reported that obesity is associated with an increased cholesterol synthesis rate, equal to about 20 mg d −1 for each kilogram of body fat . BMI was shown to be positively correlated with TG and LDL‐C, and negatively with HDL‐C ; and overweight/obesity is positively associated with the prevalence of dyslipidaemia in adolescents . Our review finds that 70% of the interventions had a similar effect on adiposity measures and blood lipids; interventions having a significant desirable effect on adiposity measures led to a significantly greater improvement in LDL‐C, HDL‐C and TG.…”

Section: Discussionmentioning

confidence: 54%

Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta‐analysis

Cai

Wilson

et al. 2014

Obesity Reviews

View full text Add to dashboard Cite

Summary Aim We aimed to assess the effects of childhood obesity prevention programs on blood lipids in high-income countries. Methods We searched MEDLINE®, Embase, PsychInfo, CINAHL®, clinicaltrials.gov, and the Cochrane Library up to April 22, 2013 for relevant randomized controlled trials, quasi-experimental studies, and natural experiments published in English. Studies were included if they implemented diet and/or physical activity intervention(s) with ≥ one year follow up (or ≥ six months for school-based intervention studies) in 2 to 18 years old, and were excluded if they targeted only overweight/obese children, or those with a pre-existing medical condition. Results Seventeen studies were finally included. For total cholesterol, the pooled intervention effect was −0.97 mg/dL (95% CI: −3.26, 1.32; P=0.408); for low density lipoprotein-cholesterol (LDL-C), −6.06 mg/dL (95% CI: −11.09, −1.02; P=0.018); for high density lipoprotein-cholesterol (HDL-C), 1.87 mg/dL (95% CI: 0.39, 3.34; P=0.013); and for triglycerides, −1.95 mg/dL (95% CI: −4.94, 1.04; P=0.202). Most interventions (70%) showed similar significant or no effects on adiposity- and lipids outcomes: 15% interventions improved both adiposity- and lipids outcomes; 55% had no significant effects on either. Conclusions Childhood obesity prevention programs had a significant desirable effect on LDL-C and HDL-C. Two-thirds of interventions showed similar significant or no effects in adiposity- and lipids outcomes. Assessing lipids outcomes provide additional useful information on obesity prevention program benefits.

show abstract

“…It is worthwhile comparing the data from this cohort of European children with those from another European cohort of adolescents (HELENA 42 ) studied in 2006-hence comparing two European birth cohorts with a time interval of on average around 6 years.…”

Section: Discussionmentioning

confidence: 99%

Blood lipids among young children in Europe: results from the European IDEFICS study

et al. 2014

Self Cite

View full text Add to dashboard Cite

on behalf of the IDEFICS consortium BACKGROUND: Measurement of cholesterol and triglyceride (TG) fractions in blood has become standard practice in the early detection of atherosclerotic disease pathways. Considerable attention is given nowadays to the presence of these risk factors in children and to start preventive campaigns early in life. In this context, it is imperative to have valid comparative frameworks for interpretation of lipid levels. The aim of this study is to present sex-and age-specific reference values on blood lipid levels in European children aged 2.0-10.9 years. METHODS: Fasting blood was obtained via either venipuncture or capillary sampling. In 13 579 European non-obese children (50.3% boys), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TG and TC/HDL-C ratio levels were measured with a point-of-care analyser (Cholestech). Sex-and age-specific reference values were computed with the GAMLSS method with the statistical software R. RESULTS: Reference curves and 1st, 3rd, 10th, 25th, 50th, 75th, 90th, 97th and 99th percentile values are presented. HDL-C showed a positive trend with age, from 2 years onwards, but was relatively stable above the age of 7. For LDL-C and TC, linear but small age-related trends were seen. The TC/HDL-C values showed a gradual negative trend from the age of 2 up to 6 and were relatively stable afterwards. For TG, no age trend was found (P = 0.285). Boys had higher mean HDL-C values than girls (1.414 vs 1.368 mmol l − 1 ), and lower TC, LDL-C, TC/HDL-C and TG values (3.981 vs 4.087 mmol l − 1 ; 2.297 vs 2.435 mmol l − 1 ; 2.84 vs 3.01mmol l − 1 ; and 0.509 vs 0.542 mmol l − 1 , respectively). CONCLUSIONS: These new and recent references could serve as a European orientation of blood lipid values in children in the context of standard medical practice and for the purpose of public health screening.

show abstract

Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat—The HELENA Study

Cited by 24 publications

References 36 publications

Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia

Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia

Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta‐analysis

Blood lipids among young children in Europe: results from the European IDEFICS study

Contact Info

Product

Resources

About