Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats

Khanna, Ashok; Rizvi, Farhan; Chander, Ramesh

doi:10.1016/s0378-8741(02)00136-8

Cited by 215 publications

(150 citation statements)

References 9 publications

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“…This reduction was associated with a decrease in the LDL fraction, which equates to a higher risk factor for coronary heart disease. This result suggests that the cholesterollowering activity of these novel compounds can be a result from the enhancement of the LDL catabolism through the hepatic receptor (Khanna et al, 2002).…”

Section: Discussionmentioning

confidence: 92%

Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(Benzoylphenyl)-1H-indole-2-carboxamides as Potent Antihypertriglyceridemic Agents

Shahwan

Shattat

Al-Qirim

et al. 2010

Zeitschrift Für Naturforschung C

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The N-(benzoylphenyl)-1H-indole-2-carboxamide derivatives 1 -6 were synthesized, and the lipid-lowering effects of two of these novel compounds were studied using hyperlipidemic rats as an experimental model. Treatment of ethyl-1H-indole-2-carboxylate with aminobenzophenones in the presence of sodium ethoxide and DMF, followed by purifi cation using column chromatography, gave the target compounds in good yields. The tested animals were divided into control, hyperlipidemic, compounds 2-, 3-and bezafi brate-treated groups. At a dose of 15 mg/kg body weight, compounds 2, 3 and bezafi brate signifi cantly reduced the elevated plasma triglyceride levels after 7 and 24 h. Furthermore, the high-density lipoprotein-cholesterol levels were remarkably increased in all treated groups after 7 and 24 h compared to the hyperlipidemic control group. However, only compounds 2-and 3-treated groups obviously showed a signifi cant reduction in plasma total cholesterol levels after 24 h. It is therefore reasonable to assume that 2 and 3 may have a promising potential in the treatment of hyperlipidemia and coronary heart diseases.

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Section: Discussionmentioning

confidence: 92%

Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(Benzoylphenyl)-1H-indole-2-carboxamides as Potent Antihypertriglyceridemic Agents

Shahwan

Shattat

Al-Qirim

et al. 2010

Zeitschrift Für Naturforschung C

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“…A shift in the Ca 2+ curves to the right would have confirmed CCB Effect on tyloxapol-induced hyperlipidemia. The tyloxapol-induced hyperlipidemic model 12 was followed with slight modifications. Male SD rats weighing 160-180 g were randomly divided into three groups (n¼6 each).…”

Section: Pharmacological Parametersmentioning

confidence: 99%

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

et al. 2009

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The objective of this study was to investigate the possible mode(s) of action for the medicinal use of Orchis mascula (OM) (family Orchidaceae) in hypertension and dyslipidemia. In spontaneously hypertensive rats (SHRs), OM significantly (Po0.05) reduced systolic blood pressure to 174.2±9.63 vs. 203.4±7.13 mm Hg (mean±s.e.m.; n¼7-10) and improved endothelial dysfunction by increasing acetylcholine-induced relaxation. In normotensive anesthetized rats, the crude extract of OM (Om.Cr) at 10 and 30 mg kg À1 caused a dose-dependent attenuation of mean arterial pressure. OM also decreased serum triglycerides to 29.28 ± 6.99 vs. 93.84 ± 5.7 mg per 100 ml (Po0.001), low-density lipoprotein-cholesterol to 5.99 ± 1.27 vs. 21.9 ± 3.5 mg per 100 ml (Po0.05) and atherogenic index to 0.096±0.017 vs. 0.36±0.08 mg per 100 ml (Po0.05). OM significantly reduced lipid levels in tyloxapol and high fat diet-induced hyperlipidemia. In a second model, OM also reduced gain in body weight with a reduction in daily diet consumption. In isolated rabbit aorta, Om.Cr caused concentration-dependent relaxation of both phenylephrine and high K + (80 mM)-induced contractions and a rightward shift of the calcium concentration-response curves similar to the effect seen with verapamil. In conclusion, OM shows antihypertensive and endothelial-modulating effects mediated through multiple pathways that include direct vasodilation by calcium channel blockade and reduction of plasma lipids by inhibition of biosynthesis, absorption and secretion. This study rationalizes the medicinal use of OM in hypertension and dyslipidemia. However, further studies are required to identify the active constituents of this plant.

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“…The presence of hyperlipidemia compounds in aqueous extract of Phragmites australis that may act as inhibitors for some enzymes such as hydroxy methyl glutaryl-CoA reductase, which participates in cholesterol synthesis or reduce intestinal absorption of cholesterol [29] or the plant extract might stimulate the production of insulin which in turn inhibits lipoprotein lipase activity or reduces lipid peroxidation [30]. On the other hand flavonoid contents in aqueous extract of Phragmites australis have a role in enhancing absorption of low-density lipoprotein (LDL) by increasing LDL receptors, increasing the activity of lecithin-cholesterol acyltransferase (LCAT) and tissue lipases and/or inhibition of acetylCoA carboxylase [31,32]. In the present study, the significant rises in serum glutamate-oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), amylase and alkaline phosphatase (ALP) activities that were observed in alloxan-induced diabetic rats when compared to the control.…”

Section: Discussionmentioning

confidence: 99%

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Derouiche

Manel

Hamida

2017

Int J Pharm Pharm Sci

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Objective: The present study was aimed to investigate the effects of the aqueous extract of rhizome of phragmites australis on carbohydrate metabolism, some enzyme activities and pancreatic tissue in alloxan induced diabetic rats. Methods:Wistar rats were divided into three groups (n=6) as control, diabetic group and test groups (Diabetic+AEPA). Diabetes in rats was induced by alloxane using a single peritoneal injection of 150 mg/kg dose. Aqueous extract of Phragmites australis was supplemented (200 mg/kg b. w) orally for three weeks. The aqueous extract of Phragmites australis was prepared and phytochemical were analyzed by using standard methods. Blood glucose level, pancreas histology and various biochemical parameters were assessed. Results:The results of the phytochemical analysis of aqueous extract of Phragmites australis (AEPA) revealed the presence of tannin, terpenoids, glycosides and flavonoids. Compared with the control, a significant decrease in the body weight gain (p<0.01) and increase in food intake (p<0.001) were noticed in the diabetic group. The biochemical evaluation showed significantly higher values for glucose (p<0.001), lipid profile (p<0.05), transaminases (p<0.05), amylase and alkaline phosphatase (p<0.001) activities in diabetic group compared with the control. Histology of the pancreas showed congestion of vessels and focal area of necrosis in diabetic untreated rats. However, treatment with aqueous extract of Phragmites australis significantly normalized blood glucose, serum biochemical profile and pancreas histomorphology. Conclusion:It is suggested that aqueous extract of Phragmites australis exhibits a benefic effect in rat to a great extent in attenuating and restoring the damage sustained by diabetes.

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Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats

Cited by 215 publications

References 9 publications

Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(Benzoylphenyl)-1H-indole-2-carboxamides as Potent Antihypertriglyceridemic Agents

Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(Benzoylphenyl)-1H-indole-2-carboxamides as Potent Antihypertriglyceridemic Agents

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

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