Lipid-lowering agents for preventing melanoma

Dellavalle, R.; McNealy, Kristie; Graber, Marla M.; Morelli, John N.; Schilling, Lisa M.

doi:10.1002/14651858.cd003697

Cochrane Database of Systematic Reviews 2002

DOI: 10.1002/14651858.cd003697

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Lipid-lowering agents for preventing melanoma

R. Dellavalle

Kristie McNealy

Marla M. Graber

et al.

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2003

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Cited by 1 publication

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Chemoprevention of Melanoma: An Unexplored Strategy

Demierre

Nathanson

2003

JCO

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The incidence and mortality of melanoma has continued to increase steeply-faster than most other preventable cancers in the United States. Current sun protection strategies have yet to reduce this increased incidence and mortality. Chemoprevention, defined as the use of natural or synthetic agents to delay, reverse, suppress, or prevent premalignant molecular or histologic lesions from progressing to invasive cancer, has become an important area in cancer research. Melanoma, with its associated risk factors and its known precursors or premalignant lesions, should lend itself well to chemoprevention. Prerequisites for this research should include determination of the molecular mechanisms of ultraviolet (UV) melanomagenesis; use of animal models to test candidate prevention agents; use of molecular and histologic markers as surrogate end point markers; collection of epidemiological, basic science, or in vitro data on potential chemoprevention candidate drugs; and selection of a high-risk patient population in which to carry out clinical chemoprevention trials. Preliminary data available in all these areas are reviewed. Possible mechanisms and molecular targets for the chemoprevention of UV-induced melanoma are discussed. This recent information should stimulate research in the chemoprevention of melanoma.

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Chemoprevention of Melanoma: An Unexplored Strategy

Demierre

Nathanson

2003

JCO

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Lipid-lowering agents for preventing melanoma

Cited by 1 publication

References 23 publications

Chemoprevention of Melanoma: An Unexplored Strategy

Chemoprevention of Melanoma: An Unexplored Strategy

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