Lipid-lowering and antioxidative effects of<i>Apium graveolens</i>L. root flavonoid extracts

He, Yuan; Shi, Yang; Zhang, Airong; Zhang, Xiaoxia; Sun, Jing; Tian, Lianhua

doi:10.1039/c9ra04481g

Cited by 11 publications

(5 citation statements)

References 41 publications

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“…It is rich in compounds including limonene, selinene, glycosides, flavonoids, and vitamins [11]. ese constituents are also reported to prevent cardiovascular diseases [12], jaundice [13], urinary tract obstruction [14], gout [15], and rheumatic disorders [16,17]. Celery seeds are spicy, carminative [18], diuretic [19], appetizer [20], stimulant, hypotensive [21], aphrodisiac, anti-inflammatory, and laxative [22].…”

Section: Introductionmentioning

confidence: 99%

Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC‐TOF‐MS and UHPLC‐MS/MS

Qiao

Yang

Zhao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Although several studies have been performed on Apium graveolens L.(celery) seeds, their antiliver fibrosis effects remain to be unexplored. Firstly, we detected the effects of celery seeds extracted with different concentrations of aqueous ethanol on the proliferation of HSC-LX2 cells. Then, we detected the effects of fractions of the optimal effect extract on the proliferation and apoptosis of HSC-LX2 cells. Finally, the compounds of petroleum ether (PP), ethyl acetate (PE), n-butyl alcohol (PB), and water fractions (PW) of the optimal effect extract were determined by GC-TOF-MS and UHPLC-MS/MS, to confirm the potentially antifibrotic compounds combined with pharmacodynamic experiment of monomer compounds in vitro. The results revealed that 60% ethanol extract of celery seeds (60-extract) exhibited remarkable inhibition effect on the proliferation of HSC-LX2 cells compared with 95% ethanol and aqueous extract. Besides, it validated that the inhibition rates of PP, PE, PB, and PW on the proliferation of HSC-LX2 cells were 75.14%, 73.52%, 54.09%, and 43.36%, and their percentage of apoptotic cells were 37.5%, 4.3%, 0.7%, and 0.1% at high doses, respectively. Additionally, it was manifested that apigenin, aesculetin, and butylphthalide have major contribution to the overall compounds of celery seeds, and the inhibition effects on the cell proliferation clearly elevated with increase in their contents. In essence, apigenin, aesculetin, and butylphthalide may hopefully become the natural products of antiliver fibrosis, which laid a foundation for the subsequent development of celery seeds as antiliver fibrosis drugs.

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Section: Introductionmentioning

confidence: 99%

Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC‐TOF‐MS and UHPLC‐MS/MS

Qiao

Yang

Zhao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Thus, these drugs reduce the fatty acid synthesis and cellular fatty acid uptake. The previous studies reported that A. graveolence Lin seeds [28,29] Piperine [21] and vinegar [30,31] downregulate ACC, FAS. A. graveolence Lin seeds [29,32] Piperine, [21] P. anisum Lin seeds, [23] and A. cepa Lin bulb inhibits the activity of HMG-CoA reductase in animal models [26] A. cepa Lin bulb also inhibits lipogenic enzyme Glucose 6 phosphate dehydrogenase and malic enzyme.…”

Section: Discussionmentioning

confidence: 95%

“…The previous studies reported that A. graveolence Lin seeds [28,29] Piperine [21] and vinegar [30,31] downregulate ACC, FAS. A. graveolence Lin seeds [29,32] Piperine, [21] P. anisum Lin seeds, [23] and A. cepa Lin bulb inhibits the activity of HMG-CoA reductase in animal models [26] A. cepa Lin bulb also inhibits lipogenic enzyme Glucose 6 phosphate dehydrogenase and malic enzyme. [26] Suppression of ACC, FAS, [33] HMG-CoA reductase, [34] Glucose 6 phosphate dehydrogenase, and malic enzyme activity [35] reduces biosynthesis of endogenous lipids.…”

Section: Discussionmentioning

confidence: 95%

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2022

IJGP

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Background: Metabolic syndrome is a cluster of risk factors for CVD and diabetes. The number of individuals with metabolic syndrome continues to rise. The current study aimed to test the efficacy and safety of an Integrative Unani personalized regimen (IUPR) in reducing the risk factors of metabolic syndrome. Materials and Methods: Patients according to NCEP ATP III criteria were selected, 50 patients (30 in the test group and 20 in the control group) completed the study. The test group was treated with an IUPR and the control group was treated for respective risk factors with standard drugs for 2 months. The response was measured by changes in TC, TG, HDL, FBS, BP, WC, and Weight. Results: IUPR was found superior in reducing body weight, waist circumference, and BP (P < 0.01), equivalent in reducing serum triglyceride and fasting blood sugar level and inferior in reducing total cholesterol compared to standard drugs provided for respective risk factors after 2 months of intervention. HDL increased by 1.033 mg/dl in the test and decreased in the control group by 4.850 mg/dl. Conclusion: In metabolic syndrome lipid storage increases due to the deterrence of the pathological mechanisms. Unani regimen caused a reduction in risk factors of the metabolic syndrome might be by attenuation in physiological changes possibly by reverting rate-limiting enzymes and increasing energy expenditure. Long-term high-quality trials with dietary modification are needed to get optimal results.

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“…A reasonable explanation for this result is that the increase in temperature increased the solubility of the powders. After superfine pulverization, the particle size of the AR powders decreased, and their specific surface area substantially increase significantly, thereby exposing the hydrophilic groups of the powders and increasing the contact area with water (He, Shi, et al, 2019b). Therefore, the powders with a small particle size dissolved better in water than those with a large particle size, thereby improving the WSI of the AR powders.…”

Section: Resultsmentioning

confidence: 99%

Effects of superfine pulverization technology on the morphology, microstructure, and physicochemical properties of Apium graveolens L. root

Sun

Wang

et al. 2022

Microscopy Res & Technique

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Lipid-lowering and antioxidative effects ofApium graveolensL. root flavonoid extracts

Abstract: Apium graveolens L. root flavone extract can improve hyperlipidemia induced by high-fat emulsion diet in rats.

Cited by 11 publications

References 41 publications

Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC‐TOF‐MS and UHPLC‐MS/MS

Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC‐TOF‐MS and UHPLC‐MS/MS

Untitled

Effects of superfine pulverization technology on the morphology, microstructure, and physicochemical properties of Apium graveolens L. root

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