Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells

Wang, Zheng; Cheng, Qian; Tang, Ke; Sun, Yanling; Zhang, Ke-Ke; Zhang, Yi; Luo, Shunqun; Zhang, Huafeng; Ye, Duyun; Huang, Bo

doi:10.1016/j.canlet.2015.04.030

Cited by 60 publications

(48 citation statements)

References 43 publications

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“…CXCR5 expressing B cells stimulated by CXC13 coupled CpG-ODN can trigger the cytolytic effect of CD8 + T cells leading to the abrogation of metastasis in 4T1.2 tumour-bearing mice [23]. Resveratrol, Lipoxin, Glucosides of Paeony have also inhibited Bregs through STAT3 and/or ERK inactivation leading to a reduction in IL-10 and TGF-β levels thus exerting an anti-tumour effect [87]. B-cell homeostasis and thus polarity will largely be determined by the degree of inflammation within the tumour, factors such as tissue hypoxia, intra-tumoural vascularity, cytokine milieu and cellular infiltration are all factors which are likely to exert control over the pro versus anti-tumour B-cell balance but as yet there is little evidence describing the Breg/B effector ratio in tumour biology, and this is likely due to the transient inducible nature of Bregs.…”

Section: B-cell Milieu In Nsclcmentioning

confidence: 99%

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Patel

Richter

Drayson

et al. 2020

Cancer Immunol Immunother

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Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro-or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.

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Section: B-cell Milieu In Nsclcmentioning

confidence: 99%

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Patel

Richter

Drayson

et al. 2020

Cancer Immunol Immunother

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“…Overexpression is associated with poor prognosis in urothelial cancer [73] Lipoxins (lipoxin A4) Suppressing the polarization of B regulatory cells [74] (vasodilator), heparin (anticoagulant), serotonin, dopamine, tryptase, and chymase. The mast cell activation stimulates the production of leukotrienes and cytokines (e.g., TNF-α) and the cell degranulation [86].…”

Section: Thromboxanesmentioning

confidence: 99%

Neuroimmunoendocrine Interactions in Tumorigenesis and Breast Cancer

Ruiz-Manzano¹,

Ochoa-Mercado²,

Segovia-Mendoza³

et al. 2020

Tumor Progression and Metastasis

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Organism homeostasis is regulated through the tri-directional relationships between immune, endocrine, and nervous systems. These relationships are established by a complex network of chemokines, cytokines, hormones (peptide and non-peptide), neurotransmitters, and neurohormones that act onto its target cells, through common receptors. Despite initial attribution of the exclusive action of each molecule group (neurotransmitters, hormones, and cytokines), to the function of one specific system (nervous, endocrine, and immune, respectively), ligand and receptor pleiotropy and redundancy showed the multidirectional communication between systems. Cancer and metabolic and autoimmune diseases get established when homeostasis is disrupted. These interactions act in different disease levels, in cancer, since initial immunosurveillance phase, until immunosubversion and metastasis, in all cases is crucial for tumor development, cancer outcome, and patient prognosis.

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“…In the ascites of ovarian cancer patients, the frequencies of IL-10 + B cells are also positively correlated with the frequencies of CD4 + Foxp3 + Tregs [61]. In another study, when targeting Bregs by Lipoxin A4, the number of Tregs decreases in the draining lymph nodes and tumor tissues [80], thereby emphasizing the important effect of Bregs on inducing the frequency and distribution of Tregs. Kessel et al also demonstrated that human Bregs can enhance the expression of Foxp3 and CTLA-4 (markers for the suppressive capability of the function of Tregs) in Tregs through cell-to-cell contact [72].…”

Section: Negative Effect Of B Lymphocytes On the Immune Systemmentioning

confidence: 99%

Positive and negative functions of B lymphocytes in tumors

et al. 2016

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Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing. On the other hand, B lymphocytes have tumor-promoting functions. A typical type of B lymphocytes, termed regulatory B cells, is confirmed to attenuate immune response in a tumor environment. In this paper, we summarize the current understanding of B-cell functions in tumor immunology, which may shed light on potential therapeutic strategies against cancer.

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Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells

Cited by 60 publications

References 43 publications

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Neuroimmunoendocrine Interactions in Tumorigenesis and Breast Cancer

Positive and negative functions of B lymphocytes in tumors

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