Lipid membrane composition influences drug release from dioleoylphosphatidylethanolamine-based liposomes on exposure to ultrasound

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

“…This will be accomplished by using high frequency focused US probes. However, previous studies have shown that sonosensitivity of the liposomes are comparable using 40 kHz and 1.13 MHz US (Evjen et al, 2011b).…”

“…(standard liposomal DXR) during in vitro exposure to US Evjen et al, 2011a;Evjen et al, 2011b). An US enhanced therapeutic activity of DSPE-based liposomal DXR was demonstrated in tumoured mice (Hagtvet et al, 2010).…”

New Developments in Liposomal Drug Delivery

“…Enhanced permeation of the blood−brain barrier has also been observed. 282,283 An US stimulus transfers energy to the encapsulated gas pockets in the ELIPs, leading to bubble expansion and collapse causing disruptions to the liposome bilayer membrane 284,285 and release of the encapsulated materials. NF-κB oligonucleotides were encapsulated in ELIPs (800 nm), which released the oligonucleotides efficiently on application of a 1 MHz continuous wave of US.…”

Ultrasound Improves the Uptake and Distribution of Liposomal Doxorubicin in Prostate Cancer Xenografts

“…The release of doxorubicin from liposomes may be caused by either thermal or mechanical effects. Evjen and co-workers found that lipid composition can influence the degree of US-mediated drug release from liposomes (Evjen et al 2011b) and suggested that certain sonosensitive liposomes may release their contents as result of destabilization of the lipid bilayer (Evjen et al 2011a). A previous study using DEPC-based liposomes reported that these liposomes remain stable during incubation at 37 C (Afadzi et al 2012), indicating that the liposomes are not affected by the temperature in the tumors.…”