Lipid Membrane Dipolar Potential Control for Electrochemical Biosensor Development

Abstract

The dipolar potentials of bilayer membranes are investigated as physical features which can be selectively altered by membrane chemical composition changes or membrane intrinsic receptor‐stimulant complexing interactions. The results imply that selective dipolar potential modification can lead to analytically useful signals in the form of transmembrane ion permeability changes. The dipolar potential and membrane molecular packing/fluidity apparently operate interdependently in a synergic manner which can chemically amplify analytical ion current signals.

Chemical sensors

“…The reason is that the chemical modulation of the barrier properties of phospholipid membranes is the very essence of the sensory and nerve-impulse transmission mechanisms in living organisms (335). The principles of the use of the barrier properties of the membranes for chemical sensing have been elaborated (14, 336) and some preliminary experiments to support these hypotheses have been made (337)(338)(339)(340)(341)(342). Other supporting evidence comes from the patch-microelectrode techniques in which the permeability of natural membranes for ions in monitored (343).…”