Lipid metabolism and cancer

Bian, Xueli; Li, Rui; Meng, Ying; Xing, Dongming; Xu, Daqian; Lu, Zhimin

doi:10.1084/jem.20201606

Cited by 511 publications

(388 citation statements)

References 206 publications

(242 reference statements)

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“…Dysregulated lipid metabolism is the most prominent metabolic alteration in various cancers, playing a vital role in their proliferation, invasion, metastasis, and response to different therapies [ 51 ]. FABP5 , also known as epidermal FABP (E-FABP), is essential for KC homeostasis and differentiation, and maintenance of the skin-water permeability barrier by participating in fatty acid metabolism [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma

et al. 2021

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Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer characterized by high invasiveness, heterogeneity, and mainly occurs in the ultraviolet (UV)-exposed regions of the skin, but its pathogenesis is still unclear. Here, we generated single-cell transcriptome profiles for 350 cells from six primary UV-induced cSCCs, together with matched adjacent skin samples, and three healthy control skin tissues by single-cell RNA-sequencing technology based on Smart-seq2 strategy. A series of bioinformatics analyses and in vitro experiments were used to decipher and validate the critical molecular pattern of cSCC. Results showed that cSCC cells and normal keratinocytes were significantly distinct in gene expression and chromosomal copy number variation. Furthermore, cSCC cells exhibited 18 hallmark pathways of cancer by gene set enrichment analysis. Differential expression analysis demonstrated that many members belonging to S100 gene family, SPRR gene family, and FABP5 were significantly upregulated in cSCC cells. Further experiments confirmed their upregulation and showed that S100A9 or FABP5 knockdown in cSCC cells inhibited their proliferation and migration through NF-κB pathway. Taken together, our data provide a valuable resource for deciphering the molecular pattern in UV-induced cSCC at a single-cell level and suggest that S100A9 and FABP5 may provide novel targets for therapeutic intervention of cSCC in the future.

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Section: Discussionmentioning

confidence: 99%

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma

et al. 2021

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“…Lipid metabolism in cancer: an overview Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules regulating proliferation, survival, metastasis, and response to environmental cue and therapy [30,31]. Specifically, highly proliferative cancer cells show a strong lipid avidity, by either increasing uptake of exogenous lipids and lipoproteins, or boost the endogenous lipid synthesis (lipogenesis) [31,32] (Fig.…”

Section: Accepted Articlementioning

confidence: 99%

“…stimulates FASN expression resulting in elevated palmitate production [30]. PPARs are widely regarded as monitors of intracellular non-esterified fatty acid (NEFA) levels and the composition of the intracellular NEFA pool is likely an important factor controlling PPAR signaling [144].…”

Section:  Conclusion and Future Perspectivesmentioning

confidence: 99%

PPARα at the crossroad of metabolic–immune regulation in cancer

et al. 2021

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Rewiring metabolism to sustain cell growth, division and survival is the most prominent feature of cancer cells. In particular, dysregulated lipid metabolism in cancer has received accumulating interest, since lipid molecules serve as cell membrane structure components, secondary signaling messengers, and energy sources. Given the critical role of immune cells in host defense against cancer, recent studies have revealed that immune cells compete for nutrients with cancer cells in the tumor microenvironment and accordingly develop adaptive metabolic strategies for survival at the expense of compromised immune functions. Among these strategies, lipid metabolism reprogramming toward fatty acid oxidation is closely related to the immunosuppressive phenotype of tumor infiltrated immune cells, including macrophages, dendritic cells, etc. Therefore, it is important to understand the lipid-mediated crosstalk between cancer cells and immune cells in the tumor microenvironment.Peroxisome proliferator-activated receptors (PPARs) consist of a nuclear receptor family for lipid sensing, and one of the family members PPARα is responsible for fatty acid oxidation, energy homeostasis and regulation of immune cell functions. In this review, we discuss the emerging role of PPARα-associated metabolic-immune regulation in tumor infiltrated immune cells, and key metabolic events and pathways involved, and as well as their influences on anti-tumor immunity.

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“…Cancer cells in the tumor microenvironment, where nutrient availability is consistently changing during tumor progression, harness lipid metabolism to support their proliferation, survival, migration, invasion, and metastasis [ 1 ]. When nutrients in the tumor microenvironment are sufficient, lipids such as triglycerides, steryl esters, and retinyl esters are stored in lipid droplets, which are dynamic lipid‐rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin (PLIN) family.…”

mentioning

confidence: 99%

“…They increase fatty acid uptake by upregulating the expression of fatty acid transporters, which include the cluster of differentiation 36 (CD36, also known as fatty acid translocase), the family of fatty acid transport proteins (FATPs, also known as SLC27), and plasma membrane fatty acid‐binding proteins (FABPs). Similarly, increased uptake of cholesterol in the form of low‐density lipoproteins (LDLs) is mediated by LDL receptors (LDLRs) that are transcriptionally upregulated by activated SREBP1 and PTEN loss‐induced PI3K/AKT activation [ 1 ]. Third, cancer cells mobilize endogenous structural lipids.…”

mentioning

confidence: 99%

Lipid metabolism and cancer

Cited by 511 publications

References 206 publications

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma

PPARα at the crossroad of metabolic–immune regulation in cancer

A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells

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