Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

Mitrofanova, Darya; Dakik, Pamela; McAuley, Mélissa; Medkour, Younes; Mohammad, Karamat; Titorenko, Vladimir I.

doi:10.2741/4638

Cited by 12 publications

(24 citation statements)

References 241 publications

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“…After the neutral lipids triacylglycerols (TAG) are synthesized in the endoplasmic reticulum (ER), they are stored in lipid droplets (LD) as the source of free (non-esterified) fatty acids for energy metabolism and phospholipid biosynthesis [ 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. One of the characteristic traits of Q and NQ cell sub-populations formed in S. cerevisiae cultured under CR conditions is a considerable decline in TAG concentration, as compared to age-matched Q and NQ cell sub-populations developed in this yeast cultured under non-CR conditions ( Figure 2 F) [ 24 , 25 ].…”

Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning

confidence: 99%

“…Cardiolipins (CL) are signature lipids of the inner mitochondrial membrane essential for the maintenance of proper morphology and functionality of yeast mitochondria [ 68 , 75 , 76 , 77 , 78 , 79 ]. Mitochondria of both Q and NQ cell sub-populations in S. cerevisiae limited in calorie supply exhibit an increase in CL concentration beginning of the PD growth phase ( Figure 2 G) [ 24 , 25 ].…”

Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning

confidence: 99%

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Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast

Mohammad

Junio

Tafakori

et al. 2020

IJMS

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After Saccharomyces cerevisiae cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discussed here. We also describe various hallmarks of quiescent and non-quiescent yeast cells. A complex aging-associated program underlies cellular quiescence in budding yeast. This quiescence program includes a cascade of consecutive cellular events orchestrated by an intricate signaling network. We examine here how caloric restriction, a low-calorie diet that extends lifespan and healthspan in yeast and other eukaryotes, influences the cellular quiescence program in S. cerevisiae. One of the main objectives of this review is to stimulate an exploration of the mechanisms that link cellular quiescence to chronological aging of budding yeast. Yeast chronological aging is defined by the length of time during which a yeast cell remains viable after its growth and division are arrested, and it becomes quiescent. We propose a hypothesis on how caloric restriction can slow chronological aging of S. cerevisiae by altering the chronology and properties of quiescent cells. Our hypothesis posits that caloric restriction delays yeast chronological aging by targeting four different processes within quiescent cells.

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Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning

confidence: 99%

Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning

confidence: 99%

Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast

Mohammad

Junio

Tafakori

et al. 2020

IJMS

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“…Lipids are a vital nutrient widely utilized in almost all tissues of the body, and they play a key role in animal growth and development [21]. However, lipid transport requires special protein transporters in circulation (blood) because lipids are water-insoluble and amphiphilic [7,22]. Hence, in the present study, we first focused on genes encoding lipid transporters, including ALB, CHKA, and APOH.…”

Section: Discussionmentioning

confidence: 99%

“…An earlier transcriptomic analysis in chickens showed that the gene expression difference between high RFI (HRFI) and low RFI (LRFI) animals can be explained by differences in cell division, growth, proliferation and apoptosis, protein synthesis, lipid metabolism, and transport of cellular molecules [6]. Particularly, components of lipid metabolism, including fatty acid profiles, lipid transport, lipid oxidation, and enzyme activities affect feed efficiency traits [7]. Lipid transport plays an especially crucial role in lipid metabolism and involves two opposite biological processes in tissues: loading, involving energy utilization and storage, and unloading, involving endogenous synthesis and lipid release [8].…”

Section: Introductionmentioning

confidence: 99%

Expression of genes related to lipid transport in meat-type ducks divergent for low or high residual feed intake

Jin

Zang

et al. 2020

Asian-Australas J Anim Sci

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Objective: This study examined the effects of divergence in residual feed intake (RFI) on expression profiles of key genes related to lipid transport in the liver and duodenal epithelium and their associations with feed efficiency traits in meat-type ducks. Methods: A total of 1,000 male ducks with similar body weight (1,042.1±87.2 g) were used in this study, and their individual RFI was calculated from 21 to 42 d of age. Finally, the 10 highest RFI (HRFI) and 10 lowest RFI (LRFI) ducks were chosen for examining the expression of key genes related to lipid transport in the liver and duodenal epithelium using quantitative polymerase chain reaction. Results: In the liver, expression levels of albumin (ALB), CD36 molecule (CD36), fatty acid hydroxylase domain containing 2 (FAXDC2), and choline kinase alpha (CHKA) were significantly higher in LRFI ducks than in HRFI ducks (p<0.01); negative correlations (p<0.05) between expression levels of ALB, CD36, FAXDC2, and CHKA and RFI were detected in the liver. Additionally, ALB expression was strongly positively correlated (p<0.05) with CD36, FAXDC2, CHKA, and apolipoprotein H (APOH) expression in the liver. In duodenal epithelium, we found that mRNA levels of ALB, CD36, FAXDC2, and APOH were significantly higher in LRFI ducks than in HRFI ducks (p<0.01); RFI was strongly negatively correlated (p<0.05) with ALB, FAXDC2, and APOH expression, while ALB expression was strongly positively correlated with APOH expression (p<0.01) in duodenal epithelium. Furthermore, expression levels of both ALB and FAXDC2 genes were significantly associated with feed conversion ratio and RFI in both liver and duodenal epithelium (p<0.05). Conclusion: Our findings therefore suggest that ALB and FAXDC2 genes might be used as potential gene markers designed to improve feed efficiency in future meat-type duck breeding programs.

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“…Lipid homeostasis is of utmost importance to maintain longevity of yeast cells and persistent deviations thereof can lead to cell demise and a phenomenon described as liponecrosis 105 179 180 181 . Several observations indicate that alterations in lipid homeostasis induce mechanisms involved in protein quality control.…”

Section: Ph Control Stress Tolerance and Longevitymentioning

confidence: 99%

pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity

Deprez¹,

Eskes²,

Wilms³

et al. 2018

Microb Cell

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The plasma membrane H+-ATPase Pma1 and the vacuolar V-ATPase act in close harmony to tightly control pH homeostasis, which is essential for a vast number of physiological processes. As these main two regulators of pH are responsive to the nutritional status of the cell, it seems evident that pH homeostasis acts in conjunction with nutrient-induced signalling pathways. Indeed, both PKA and the TORC1-Sch9 axis influence the proton pumping activity of the V-ATPase and possibly also of Pma1. In addition, it recently became clear that the proton acts as a second messenger to signal glucose availability via the V-ATPase to PKA and TORC1-Sch9. Given the prominent role of nutrient signalling in longevity, it is not surprising that pH homeostasis has been linked to ageing and longevity as well. A first indication is provided by acetic acid, whose uptake by the cell induces toxicity and affects longevity. Secondly, vacuolar acidity has been linked to autophagic processes, including mitophagy. In agreement with this, a decline in vacuolar acidity was shown to induce mitochondrial dysfunction and shorten lifespan. In addition, the asymmetric inheritance of Pma1 has been associated with replicative ageing and this again links to repercussions on vacuolar pH. Taken together, accumulating evidence indicates that pH homeostasis plays a prominent role in the determination of ageing and longevity, thereby providing new perspectives and avenues to explore the underlying molecular mechanisms.

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Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

Cited by 12 publications

References 241 publications

Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast

Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast

Expression of genes related to lipid transport in meat-type ducks divergent for low or high residual feed intake

pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity

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