Lipid metabolism around the body clocks

Petrenko, Volodymyr; Sinturel, Flore; Riezman, Howard; Dibner, Charna

doi:10.1016/j.plipres.2023.101235

Cited by 39 publications

(7 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrolyzed lipids enter the hepatocytes in the form of free fatty acids and are either β-oxidized to produce energy or stored in the liver as TG. Moreover, hepatocytes use free fatty acids or glucose for the biosynthesis of glycosphingolipids, which are principal components of cell membranes and play important roles in intracellular signal transduction [ 58 , 59 ]. PCs and LPC are key byproducts in the glycerophospholipid metabolism pathway [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying Ramulus mori (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice

Wang,

Xu,

et al. 2023

Nutrients

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder, with a global prevalence of 25%. Currently, there remains no approved therapy. Ramulus mori (Sangzhi) alkaloids (SZ-As), a novel natural medicine, have achieved comprehensive benefits in the treatment of type 2 diabetes; however, few studies have focused on its role in ameliorating hepatic lipid metabolic disturbance. Herein, the therapeutic effect and mechanism of SZ-As on a high-fat diet (HFD) combined with streptozotocin (STZ)-induced NAFLD mice were investigated via incorporating transcriptomics and lipidomics. SZ-As reduced body weight and hepatic lipid levels, restored pathological alternation and converted the blood biochemistry perturbations. SZ-A treatment also remarkedly inhibited lipogenesis and enhanced lipolysis, fatty acid oxidation and thermogenesis. Transcriptomics analysis confirmed that SZ-As mainly altered fatty acid oxidative metabolism and the TNF signaling pathway. SZ-As were further demonstrated to downregulate inflammatory factors and effectively ameliorate hepatic inflammation. Lipidomics analysis also suggested that SZ-As affected differential lipids including triglyceride (TG) and phosphatidylcholine (PC) expression, and the main metabolic pathways included glycerophospholipid, sphingomyelins and choline metabolism. Collectively, combined with transcriptomics and metabolomics data, it is suggested that SZ-As exert their therapeutic effect on NAFLD possibly through regulating lipid metabolism pathways (glycerophospholipid metabolism and choline metabolism) and increasing levels of PC and lysophosphatidylcholine (LPC) metabolites. This study provides the basis for more widespread clinical applications of SZ-As.

show abstract

Section: Discussionmentioning

confidence: 99%

Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying Ramulus mori (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice

Wang,

Xu,

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…Circadian oscillators play pivotal roles in regulating nearly all the aspects of body physiology via temporal orchestration of gene transcription, post-transcriptional events, protein synthesis and post-translational modifications (reviewed in (Bass, 2017;Finger et al, 2020)). Furthermore, lipids and metabolites follow diurnal profiles in blood and tissues, highlighting the critical importance of circadian rhythmicity for metabolic landscape (Chua et al, 2013;Held et al, 2020;Petrenko et al, 2022;Petrenko et al, 2023;Sinturel et al, 2023). The organspecific fluctuations observed in the circadian landscape emphasize the fine-tuning required for each organ and even each cell type to perform its biological role (Gachon et al, 2017;Petrenko et al, 2018;Sinturel et al, 2020).…”

Section: In Memoriammentioning

confidence: 99%

“…The circadian system and body metabolism are tightly interconnected through behavioural and molecular pathways (Allada & Bass, 2021;Bass, 2016;Finger et al, 2020;Gachon et al, 2017;Munch & Kramer, 2019;Reinke & Asher, 2019;Sinturel et al, 2020). Increasing body of evidence imply that in humans, circadian clock perturbation is associated with islet dysfunction and T2D pathogenesis (Perelis, Marcheva, et al, 2015;Perelis, Ramsey, & Bass, 2015;Petrenko et al, 2020;Petrenko et al, 2022;Petrenko et al, 2023;Saini et al, 2016). Indeed, disruption of the clock machinery in primary human islet cells using a siRNA targeting the core clock gene CLOCK revealed that a functional circadian clock is required for proper absolute and temporal regulation of glucagon and insulin secretion via regulation of the islet hormone secretory granule exocytosis, and for regulating membrane fluidity.…”

Section: Passing the Baton: Investigating Molecular Clockwork And Dai...mentioning

confidence: 99%

Human primary cells can tell body time: Dedicated to Steven A. Brown

Katsioudi,

Biancolin,

Jiménez‐Sanchez

et al. 2024

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

The field of chronobiology has advanced significantly since ancient observations of natural rhythms. The intricate molecular architecture of circadian clocks, their hierarchical organization within the mammalian body, and their pivotal roles in organ physiology highlight the complexity and significance of these internal timekeeping mechanisms. In humans, circadian phenotypes exhibit considerable variability among individuals and throughout the individual's lifespan. A fundamental challenge in mechanistic studies of human chronobiology arises from the difficulty of conducting serial sampling from most organs. The concept of studying circadian clocks in vitro relies on the groundbreaking discovery by Ueli Schibler and colleagues that nearly every cell in the body harbours autonomous molecular oscillators. The advent of circadian bioluminescent reporters has provided a new perspective for this approach, enabling high‐resolution continuous measurements of cell‐autonomous clocks in cultured cells, following in vitro synchronization pulse. The work by Steven A. Brown has provided compelling evidence that clock characteristics assessed in primary mouse and human skin fibroblasts cultured in vitro represent a reliable estimation of internal clock properties in vivo. The in vitro approach for studying molecular human clocks in cultured explants and primary cells, pioneered by Steve Brown, represents an invaluable tool for assessing inter‐individual differences in circadian characteristics alongside comprehensive genetic, biochemical and functional analyses. In a broader context, this reliable and minimally invasive approach offers a unique perspective for unravelling the functional inputs and outputs of oscillators operative in nearly any human tissue in physiological contexts and across various pathologies.

show abstract

“…Lipids are a group of organic compounds that have various physiological functions [ 1 , 2 ]. Dyslipidaemia, often manifesting as elevated triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and total cholesterol (TC) levels and diminished high-density lipoprotein (HDL) cholesterol levels [ 3 ], has been shown to contribute to the progression of cardiovascular diseases (CVDs), diabetes and obesity [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Mildly elevated serum bilirubin and its correlations with lipid levels among male patients undergoing health checkups

Bai,

Qiao,

Zhang

2023

Lipids Health Dis

View full text Add to dashboard Cite

Background Bilirubin’s ability to lower lipid levels was confirmed by several studies, but those studies mainly focused on total bilirubin (TBil). The present study aimed to elucidate the correlations of the two subtypes of bilirubin with lipid levels. Methods A total of 1732 male patients undergoing health checkups were categorized into three groups according to the levels of direct bilirubin (DBil) and indirect bilirubin (IBil). The differences in medical characteristics among the three groups were analysed. Results Subjects in the elevated DBil group had the lowest serum alanine aminotransferase (ALT), total cholesterol (TC), blood urea nitrogen (BUN), γ-glutamyl transpeptidase (γ-GT), fasting blood glucose (FBG), haemoglobin (HGB), and triglyceride (TG) levels in contrast to the other groups (P < 0.01), while subjects in the elevated IBil group had the highest ALT, γ-GT, BUN, serum creatinine (SCR), HGB, TC, and TG levels among the three groups (P < 0.01). DBil levels exhibited a significant negative correlation with TC (r = -0.777, P < 0.01) and TG (r = -0.397, P < 0.01) levels, while IBil levels exhibited a significant positive correlation with TC (r = 0.790, P < 0.01) and TG (r = 0.302, P < 0.01) levels. The frequencies of abnormal TC, TG, HGB and BUN levels were the lowest in the elevated DBil group, while the levels of these four variables were the highest in the elevated IBil group. Mildly elevated DBil levels were related to lower TG (OR = 0.112, 95% CI = 0.027–0.458) and TC (OR = 0.097, 95% CI = 0.013–0.700), and mildly elevated IBil levels were connected with increased TC (OR = 3.436, 95% CI = 2.398–4.924) and TG (OR = 1.636, 95% CI = 1.163–2.303). DBil was an independent protective factor against increased TC (OR = 0.702, 95% CI = 0.602–0.817, P < 0.01) and TG (OR = 0.632, 95% CI = 0.541–0.739, P < 0.01) levels, and IBil was an independent risk factors for increased TC (OR = 1.251, 95% CI = 1.176–1.331, P < 0.01). Conclusions DBil was an independent protective factor against high TC and TG levels. IBil was an independent risk factors for elevated TC levels. The prognostic value of IBil levels warrants further attention.

show abstract

Lipid metabolism around the body clocks

Cited by 39 publications

References 125 publications

Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying Ramulus mori (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice

Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying Ramulus mori (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice

Human primary cells can tell body time: Dedicated to Steven A. Brown

Mildly elevated serum bilirubin and its correlations with lipid levels among male patients undergoing health checkups

Contact Info

Product

Resources

About