Lipid metabolism as microecological and systemic factor in the development of periodontal disease: a review

Унаньян, К.Г.; Балмасова, И П; Царев, В.Н.; Мкртумян, А. М.; Эльбекьян, К. С.; Karakov, Karen; Гонтаренко, М.С.; Арутюнов, С Д

doi:10.37988/1811-153x_2020_3_36

Cited by 1 publication

(2 citation statements)

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“…Periodontopathogenic microbiota, to which the leading etiological significance is attributed, refers to gram-negative anaerobic bacteria such as, Porphyromonas gingivalis , Aggregatibacter actinomycetemcomitans , Tanerella forsythia , Treponema denticola , Fusobacterium nucleatum and some others. Their destructive action, caused by unique virulence factors, triggers an inflammatory process in periodontal tissues, which is accompanied by both local reactions and general changes in tissue metabolism with an increase in the level of pro-inflammatory mediators [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The complexity and diversity of factors influencing the separate phases of periodontitis pathogenesis, including a combination of polymicrobial synergy and dysbiosis, chronic inflammatory dysregulation, and genetic predisposition factors [ 4 , 14 , 15 ], have made the search for an ideal animal model of periodontitis difficult and challenging [ 9 ]. In addition, the pathogenesis of comorbid conditions aggravated by periodontitis is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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A New Way to Model Periodontitis in Laboratory Animals

Moiseev,

Donskov,

Dubrovin

et al. 2023

Dentistry Journal

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The prevalence of periodontal diseases is increasing, tends to increase with age and is considered as one of the main causes of tooth loss. To assess the effectiveness of new methods of treatment of periodontal diseases, studies on laboratory animals can be promising. The aim of the study: to develop a new method of accelerated modeling of experimental periodontitis on laboratory animals. Material and methods. The study was carried out on 22 female rats. A wire ligature was applied to the cervical area of the incisors of the animals in an eight-shaped manner. Plaque obtained from a patient with periodontitis was placed under the wire, and nicotine and ethyl alcohol solutions were injected under the gingival mucosa. A complex index has been proposed to assess inflammation. At the end of the experiment the animals were euthanized, their jaws were dissected into dentoalveolar blocks and further descriptive histologic analysis was performed. Results. On the second day the gingiva of the rats acquired a cyanotic-pink color, on the fourth day the consistency of the gingiva became friable, mobility appeared in the lower incisors. Complex index of inflammation in animals of the main group: before the study—9, on the 7th day—195. Gingival preparations showed signs of exudative inflammation. In alveolar processes—irreversible resorption of bone structures. The difference of indicators in animals before and after the experiment was statistically significant (p < 0.05). Conclusion. The new experimental model of periodontitis is reproduced in a short period of time, provides intensive development of inflammation, leads to disruption of the integrity of epithelial and connective tissue attachment, destruction of alveolar bone.

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Section: Introductionmentioning

confidence: 99%