Lipid metabolism during pregnancy: consequences for mother and child

Mulder, Janneke W.C.M.; Kusters, D. Meeike; Roeters van Lennep, Jeanine E.; Hutten, Barbara A.

doi:10.1097/mol.0000000000000927

Cited by 13 publications

(2 citation statements)

References 51 publications

(75 reference statements)

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“…During a normal pregnancy, maternal metabolic status changes dramatically, which associates with weight gain, elevated fasting blood glucose levels, insulin resistance, glucose intolerance, low grade inflammation and altered metabolic hormone levels. During early pregnancy, typically referred to as the anabolic phase, there is an increase in maternal lipid accumulation driven by increased food intake and lipogenesis [ 7 ]. Underlying the promotion of fat storage is an increase in the levels of hormones such as progesterone, leptin, prolactin and cortisol in addition to significant adipose tissue hypertrophy [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…During early pregnancy, typically referred to as the anabolic phase, there is an increase in maternal lipid accumulation driven by increased food intake and lipogenesis [ 7 ]. Underlying the promotion of fat storage is an increase in the levels of hormones such as progesterone, leptin, prolactin and cortisol in addition to significant adipose tissue hypertrophy [ 7 , 8 , 9 ]. In contrast, glucose homeostasis is maintained by increasing insulin secretion through hypertrophy and hyperplasia of pancreatic β-cells [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Sub-Optimal Paternal Diet at the Time of Mating Disrupts Maternal Adaptations to Pregnancy in the Late Gestation Mouse

Khoshkerdar,

Eid,

Batra

et al. 2024

Nutrients

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Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provision and an environment that is tolerant to the semi-allogenic foetus. While poor maternal diet during pregnancy is associated with perturbed maternal adaptations during pregnancy, the influence of paternal diet on maternal well-being is less clearly defined. We fed C57BL/6 male mice either a control (CD), low protein diet (LPD), a high fat/sugar Western diet (WD) or the LPD or WD supplemented with methyl donors (MD-LPD and MD-WD, respectively) for a minimum of 8 weeks prior to mating with C57BL/6 females. Mated females were culled at day 17 of gestation for the analysis of maternal metabolic, gut, cardiac and bone health. Paternal diet had minimal influences on maternal serum and hepatic metabolite levels or gut microbiota diversity. However, analysis of the maternal hepatic transcriptome revealed distinct profiles of differential gene expression in response to the diet of the father. Paternal LPD and MD-LPD resulted in differential expression of genes associated with lipid metabolism, transcription, ubiquitin conjugation and immunity in dams, while paternal WD and MD-WD modified the expression of genes associated with ubiquitin conjugation and cardiac morphology. Finally, we observed changes in maternal femur length, volume of trabecular bone, trabecular connectivity, volume of the cortical medullar cavity and thickness of the cortical bone in response to the father’s diets. Our current study demonstrates that poor paternal diet at the time of mating can influence the patterns of maternal metabolism and gestation-associated adaptations to her physiology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sub-Optimal Paternal Diet at the Time of Mating Disrupts Maternal Adaptations to Pregnancy in the Late Gestation Mouse

Khoshkerdar,

Eid,

Batra

et al. 2024

Nutrients

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Dictamnine Reduces Gestational Diabetic Complications in Streptozotocin-Induced Diabetic Pregnant Rats via Regulating Inflammation and NOX-2, MCP-1/AGE–RAGE Pathway

Wang,

Gao,

Zhang

et al. 2024

Rev. Bras. Farmacogn.

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Gestational diabetes mellitus is a type of diabetes that arises during pregnancy. Around 15–25% of pregnancies are affected by gestational diabetes mellitus, which involves hyperglycemia, insulin resistance, and abnormal fetal development. The present work was conducted to reveal the therapeutic potentials of dictamnine against streptozotocin-induced gestational diabetes mellitus in rats. To induce gestational diabetes mellitus, pregnant rats were administered the streptozotocin, and subsequently, the gestational diabetes mellitus rats were given dictamnine for 14 days. Following the end of treatments, the body weight, blood glucose, and fetus and placental weights were measured. The concentrations of biochemical markers, including fasting insulin, HbA1c, and hepatic glycogen, were analyzed. The lipid profiles, antioxidant levels, apoptotic proteins, and inflammatory cytokine levels were measured using the test kits. A histopathological investigation was conducted on the pancreatic tissues obtained from the experimental rats. Dictamnine treatment at concentrations of 15 and 30 mg/kg successfully reduced glucose levels, increased body weight, and regulated insulin and other biochemical marker levels in rats with gestational diabetes mellitus. The treatment of dictamnine resulted in an increase in the antioxidant levels, successfully lowered the lipid markers in the rats with gestational diabetes mellitus. The treatment with dictamnine also reduced the inflammatory cytokines, apoptotic proteins, and other molecular markers in the gestational diabetes mellitus rats. The histological study of pancreatic tissues likewise confirmed the therapeutic capabilities of dictamnine. The results of the current study emphasize that dictamnine has a positive effect on reducing gestational diabetes mellitus in rats. Graphical Abstract

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Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study

Shi,

Wu,

Zhao

et al. 2024

J of Clinical Hypertension

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Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease.

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Lipid metabolism during pregnancy: consequences for mother and child

Cited by 13 publications

References 51 publications

Sub-Optimal Paternal Diet at the Time of Mating Disrupts Maternal Adaptations to Pregnancy in the Late Gestation Mouse

Sub-Optimal Paternal Diet at the Time of Mating Disrupts Maternal Adaptations to Pregnancy in the Late Gestation Mouse

Dictamnine Reduces Gestational Diabetic Complications in Streptozotocin-Induced Diabetic Pregnant Rats via Regulating Inflammation and NOX-2, MCP-1/AGE–RAGE Pathway

Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study

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