Lipid metabolism genes and predisposition to ischemic heart disease

Churilin, M. I.; Kononov, S. I.; Маль, Г. С.; Полоников, А. В.; Лазаренко, В А

doi:10.14300/mnnc.2019.14100

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…It is widely agreed that dyslipidemia plays a crucial role in the development of atherosclerosis and coronary artery disease (CAD) [ 2 ]. Lipid metabolism abnormalities and coronary heart disease are determined by substantial effects of genetic factors [ 3 , 4 , 5 ]. According to the GWAS Catalog ( , accessed on 14 February 2019), approximately 1700 genome-wide association studies (GWAS) on over 450 cardiovascular phenotypes have been conducted, yielding substantial insights into the genetic etiology of cardiovascular disease and related traits [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Kononov

Azarova

Klyosova

et al. 2023

Genes

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We have shown that lipid-associated loci discovered by genome-wide association studies (GWAS) have pleiotropic effects on lipid metabolism, carotid intima-media thickness (CIMT), and CAD risk. Here, we investigated the impact of lipid-associated GWAS loci on the efficacy of rosuvastatin therapy in terms of changes in plasma lipid levels and CIMT. The study comprised 116 CAD patients with hypercholesterolemia. CIMT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were measured at baseline and after 6 and 12 months of follow-up, respectively. Genotyping of fifteen lipid-associated GWAS loci was performed by the MassArray-4 System. Linear regression analysis adjusted for sex, age, body mass index, and rosuvastatin dose was used to estimate the phenotypic effects of polymorphisms, and p-values were calculated through adaptive permutation tests by the PLINK software, v1.9. Over one-year rosuvastatin therapy, a decrease in CIMT was linked to rs1689800, rs4846914, rs12328675, rs55730499, rs9987289, rs11220463, rs16942887, and rs881844 polymorphisms (Pperm < 0.05). TC change was associated with rs55730499, rs11220463, and rs6065906; LDL-C change was linked to the rs55730499, rs1689800, and rs16942887 polymorphisms; and TG change was linked to polymorphisms rs838880 and rs1883025 (Pperm < 0.05). In conclusion, polymorphisms rs1689800, rs55730499, rs11220463, and rs16942887 were found to be predictive markers for multiple antiatherogenic effects of rosuvastatin in CAD patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Kononov

Azarova

Klyosova

et al. 2023

Genes

Self Cite

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Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Kononov¹,

Azarova²,

Klyosova³

et al. 2023

Preprint

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We have shown that lipid-associated loci discovered by genome-wide association studies (GWAS) have pleiotropic effects on lipid metabolism, carotid intima-media thickness (CIMT), and CAD risk. Here, we investigated the impact of lipid-associated GWAS loci on the efficacy of rosuvastatin therapy in terms of changes in plasma lipid levels and CIMT. The study comprised 116 CAD patients with hypercholesterolemia. CIMT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were measured at baseline and after 6 and 12 months of follow-up, respectively. Genotyping of fifteen lipid-associated GWAS loci was performed by the MassArray-4 System. Linear regression analysis adjusted for sex, age, body mass index, and rosuvastatin dose was used to estimate the phenotypic effects of polymorphisms, and P-values were calculated through adaptive permutation tests. Over one-year therapy, a decrease in CIMT was linked to rs1689800, rs4846914, rs12328675, rs55730499, rs9987289, rs11220463, rs16942887, and rs881844 polymorphisms (Pperm&lt;0.05). TC change was associated with rs55730499, rs11220463, and rs6065906; LDL-C change was linked to the rs55730499, rs1689800, and rs16942887 polymorphisms; and TG change was linked to polymorphisms rs838880 and rs1883025 (Pperm&lt;0.05). In conclusion, the polymorphisms rs1689800, rs55730499, rs11220463, and rs16942887 were found to be predictive markers for multiple antiatherogenic effects of rosuvastatin in CAD patients.

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Selection of Informative Genetic Markers for Assessment of Adaptabilities of Northerners: A Review

Bezmenova¹

2023

PH&LE

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Introduction: Habitation and the process of adaptation of the population of northern regions to the harsh environment are associated with the development of such syndromes and conditions as polar tension, polar dyspnea, the polar metabolic type, premature aging, and north-related hypertension, and aimed at maintaining homeostasis constancy to ensure full life activity in extreme environmental conditions, it which issues of preserving human health and labor potential remain highly relevant. Objective: To review published data on physiological and genetic adaptation to adverse climate and environmental stressors and to establish informative genetic markers for assessing adaptabilities of northerners. Materials and methods: The review includes data of Russian and foreign studies published in Russian and English languages in 1980–2021 and cited in the Pubmed, NCBI, eLIBRARY.RU, Scopus, Web of Science, and RSCI databases. Of 330 articles found, 40 full-text materials were selected for this review based on the following criteria: availability of data on polymorphic variants of genes involved in the genetic adaptation of humans to extreme conditions of the north; availability of data on epidemiology of genes associated with multifactorial diseases most common in the circumpolar zone; availability of data on adverse health effects of environmental factors in northerners, and ethnic features of gene pools of indigenous people and newcomers of the circumpolar zone. Methods of information analysis were applied to summarize the results of studies reviewed. Results: A strategy for assessing the level of functional reorganization of the human organism in the North is proposed. The article also describes a panel of informative genetic markers selected for a comprehensive assessment of adaptability of northerners, including, inter alia, normal genetic variability of adapting people, with the purpose of creating region-oriented diagnostic maps allowing assessment of total risks of cold-related illnesses for timely correction of the lifestyle and taking preventive and therapeutic measures. Discussion: In the genetic and epidemiological study of human populations living in extreme environments, it is expedient to use a comprehensive approach that includes personalized, preventive and predictive assessment of medical, psycho-physiological and genetic determinants of the functional state matrix, reflecting the current level of adaptation of northerners.

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Lipid metabolism genes and predisposition to ischemic heart disease

Cited by 3 publications

References 47 publications

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

Selection of Informative Genetic Markers for Assessment of Adaptabilities of Northerners: A Review

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