Lipid Metabolism in the Human Fetus Development

Guardamagna, Ornella; Cagliero, Paola

doi:10.1007/978-3-319-14874-8_12

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…For this reason, the highest amount of carotenes is found in the liver, testes and adrenal gland, where LDL receptor is primarily located, while xanthopylls are preferentially transported to the nervous tissue of the eye retina and the central nervous system due to the presence of HDL receptors [ 1 , 3 , 74 ]. Proteins, including albumin and lactoglobulin also participate in the transportation of carotenoids [ 75 , 76 , 77 ].…”

Section: Maternal-fetal Transfer Of Carotenoidsmentioning

confidence: 99%

“…The dominating lipoprotein fraction in the cord blood is HDL, while LDL and VLDL are found in small amounts in the fetus blood. It has also been found that unlike in adults, HDL present in the cord blood participates to a greater extent in the transport of β-carotene than LDL (55% vs. 45%) [ 75 , 76 , 77 , 78 ]. In a mouse model study, it was noticed that administering β-carotene per os has the capacity to regulate the transcription and activity of microsomal triglyceride transfer protein (MTP) as well as placental apolipoprotein B (apoB), factors necessary for the biosynthesis of lipoproteins, which overall brings about an increase in the transfer of β-carotene to the placenta [ 79 ].…”

Section: Maternal-fetal Transfer Of Carotenoidsmentioning

confidence: 99%

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Health Effects of Carotenoids during Pregnancy and Lactation

Zielińska

Wesołowska

Pawlus³

et al. 2017

Nutrients

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Adequate nutrition is particularly important during pregnancy since it is needed not only for maintaining the health of the mother, but also determines the course of pregnancy and its outcome, fetus development as well as the child’s health after birth and during the later period of life. Data coming from epidemiological and interventions studies support the observation that carotenoids intake provide positive health effects in adults and the elderly population. These health effects are the result of their antioxidant and anti-inflammatory properties. Recent studies have also demonstrated the significant role of carotenoids during pregnancy and infancy. Some studies indicate a correlation between carotenoid status and lower risk of pregnancy pathologies induced by intensified oxidative stress, but results of these investigations are equivocal. Carotenoids have been well studied in relation to their beneficial role in the prevention of preeclampsia. It is currently hypothesized that carotenoids can play an important role in the prevention of preterm birth and intrauterine growth restriction. Carotenoid status in the newborn depends on the nutritional status of the mother, but little is known about the transfer of carotenoids from the mother to the fetus. Carotenoids are among the few nutrients found in breast milk, in which the levels are determined by the mother’s diet. Nutritional status of the newborn directly depends on its diet. Both mix feeding and artificial feeding may cause depletion of carotenoids since infant formulas contain only trace amounts of these compounds. Carotenoids, particularly lutein and zeaxanthin play a significant role in the development of vision and nervous system (among others, they are important for the development of retina as well as energy metabolism and brain electrical activity). Furthermore, more scientific evidence is emerging on the role of carotenoids in the prevention of disorders affecting preterm infants, who are susceptible to oxidative stress, particularly retinopathy of prematurity.

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Section: Maternal-fetal Transfer Of Carotenoidsmentioning

confidence: 99%

Section: Maternal-fetal Transfer Of Carotenoidsmentioning

confidence: 99%

Health Effects of Carotenoids during Pregnancy and Lactation

Zielińska

Wesołowska

Pawlus³

et al. 2017

Nutrients

View full text Add to dashboard Cite

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Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring

Kang

Chiang

Wang

2020

Clinic Rev Allerg Immunol

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Origin and function of the yolk sac in primate embryogenesis

2020

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Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse. The function of the primary yolk sac and the origin of extraembryonic mesoderm remain unclear. Here, we hypothesise that the hypoblast-derived primary yolk sac serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo. We discuss the intricate relationship between the yolk sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional supply.

show abstract

Lipid Metabolism in the Human Fetus Development

Cited by 3 publications

References 85 publications

Health Effects of Carotenoids during Pregnancy and Lactation

Health Effects of Carotenoids during Pregnancy and Lactation

Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring

Origin and function of the yolk sac in primate embryogenesis

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