Lipid‐Modulated Pharmacophore Nanorods Assembled at the Air/Water Interface

Philosof-Mazor, Liron; Volinsky, Roman; Jopp, Jürgen; Blumberg, Peter M.; Rapaport, Hanna; Márquez, Víctor E.; Jelinek, Raz

doi:10.1002/cphc.200900539

Cited by 3 publications

(1 citation statement)

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“…Recent studies have shown that Langmuir monolayers of amphiphilic molecules and lipids constrain hydrophobically coated Au NPs into defined structures . We have demonstrated that careful selection of surfactant constituents and external parameters, such as temperature and surface pressure, could produce diverse Au NP configurations at the air/water interface, including nanowires, nanoislets, and nanorods, within Langmuir monolayers. , Here we present a systematic analysis of Au NP self-assembly within monolayers of saturated-chain phospholipids. Using different microscopy techniques, we detect distinct organization of the NPs, which depend upon the degree of monolayer condensation, the phospholipid chain length, and capping agents of the Au NPs.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle Self-Assembly in Saturated Phospholipid Monolayers

et al. 2010

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Self-assembly of nanostructures on surfaces is a promising area in the emerging field of "bottom-up nanolithography". We describe a systematic analysis of hydrophobically capped gold nanoparticle (Au NP) assemblies created within monolayers of saturated phospholipids deposited at the air/water interface. We show that the Au NPs are segregated within the mixed monolayers, forming distinct configurations. Microscopy analysis reveals that organized Au NP aggregates, including wires, rings, and "doughnut-shape" structures, are observed only within condensed-phase monolayers comprising phospholipids exhibiting longer acyl side-chains. In these monolayers, the Au NPs are localized at the edges of the condensed phospholipid domains. In addition to the pronounced effect of the phospholipid phases at the air/water interface, NP organization was found to depend upon the hydrophobic capping agents of the particles. The Au nanostructures assembled at the air/water interface can be transferred onto solid substrates, suggesting that the self-assembly monolayer approach could be exploited for practical nanoelectronic and sensing applications.

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Section: Introductionmentioning

confidence: 99%