Lipid nanocapsules to enhance drug bioavailability to the central nervous system

Moura, Rui Pedro; Pacheco, Catarina; Pêgo, Ana Paula; Rieux, Anne des; Sarmento, Bruno

doi:10.1016/j.jconrel.2020.03.042

Cited by 54 publications

(31 citation statements)

References 106 publications

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“…Lipid nanocapsules (LNCs) are biocompatible and biodegradable carriers that contain an inner oily core and are prepared using a solvent-free and up-scalable process that is based on the energy-efficient phase inversion temperature method [ 267 ]. LNCs may be a suitable brain drug-delivery vehicle, while surface modification can further improve bioavailability towards the central nervous system.…”

Section: Pharmaceutical-grade Cannabinoid Formulationsmentioning

confidence: 99%

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Stella

Baratta

Pepa

et al. 2021

Drugs

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The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests that phytocannabinoids are beneficial for a range of conditions. At the same time impressing development has been observed for formulations and delivery systems expanding the potential use of cannabinoids as an effective medical therapy. The objective of this review is to present the most recent results from pharmaceutical companies and research groups investigating methods to improve cannabinoid bioavailability and to clearly establish its therapeutic efficacy, dose ranges, safety and also improve the patient compliance. Particular focus is the application of cannabinoids in pain treatment, describing the principal cannabinoids employed, the most promising delivery systems for each administration routes and updating the clinical evaluations. To offer the reader a wider view, this review discusses the formulation starting from galenic preparation up to nanotechnology approaches, showing advantages, limits, requirements needed. Furthermore, the most recent clinical data and meta-analysis for cannabinoids used in different pain management are summarized, evaluating their real effectiveness, in order also to spare opioids and improve patients’ quality of life. Promising evidence for pain treatments and for other important pathologies are also reviewed as likely future directions for cannabinoids formulations.

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Section: Pharmaceutical-grade Cannabinoid Formulationsmentioning

confidence: 99%

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Stella

Baratta

Pepa

et al. 2021

Drugs

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“…Moreover, lipid nanocapsule surface modification can further improve their bioavailability towards the central nervous system. Coupling these features with alternative delivery methods that stem to disrupt or fully circumvent the blood-brain barrier may fully harness the therapeutic advance that lipid nanocapsules can supply to current treatment options [54]. Surfactants are also employed to increase brain targeting.…”

Section: Lipid Nanocapsules In Treatment Of Brain Diseasesmentioning

confidence: 99%

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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“…Unlike earlier nanocarriers, LNCs are obtained with pharmaceutically acceptable excipients based on a solvent-free soft-energy procedure. Moreover, LNCs have a high drug-loading capacity and physical stability, and a sustained drug release pattern [ 73 ]. In a word, LNCs are promising nanocarriers for drug delivery.…”

Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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Lipid nanocapsules to enhance drug bioavailability to the central nervous system

Cited by 54 publications

References 106 publications

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Lipid Based Drug Delivery System: A Review

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

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