Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders

Chu, Runxuan; Wang, Yi; Kong, Jianglong; Pan, Ting; Yang, Yani; He, Jun

doi:10.1039/d3tb02766j

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02766j

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Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders

Runxuan Chu,

Yi Wang,

Jianglong Kong

et al.

Abstract: The liver, a complex and vital organ in the human body, is susceptible to various diseases that have emerged as significant contributors to global morbidity and mortality over recent decades....

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Cited by 3 publications

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After the COVID-19 pandemic, mRNA-based vaccines have emerged as a revolutionary technology in immunization and vaccination. These vaccines have shown remarkable efficacy against the virus and opened up avenues for their possible application in other diseases. This has renewed interest and investment in mRNA vaccine research and development, attracting the scientific community to explore all its other applications beyond infectious diseases. Recently, researchers have focused on the possibility of adapting this vaccination approach to cancer immunotherapy. While there is a huge potential, challenges still remain in the design and optimization of the synthetic mRNA molecules and the lipid nanoparticle delivery system required to ensure the adequate elicitation of the immune response and the successful eradication of tumors. This review points out the basic mechanisms of mRNA-LNP vaccines in cancer immunotherapy and recent approaches in mRNA vaccine design. This review displays the current mRNA modifications and lipid nanoparticle components and how these factors affect vaccine efficacy. Furthermore, this review discusses the future directions and clinical applications of mRNA-LNP vaccines in cancer treatment.

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Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders

Abstract: The liver, a complex and vital organ in the human body, is susceptible to various diseases that have emerged as significant contributors to global morbidity and mortality over recent decades....

Cited by 3 publications

References 245 publications

Antioxidant-related enzymes and peptides as biomarkers of metallic nanoparticles (eco)toxicity in the aquatic environment

Antioxidant-related enzymes and peptides as biomarkers of metallic nanoparticles (eco)toxicity in the aquatic environment

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Advances in mRNA LNP-Based Cancer Vaccines: Mechanisms, Formulation Aspects, Challenges, and Future Directions

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