Lipid-nanoparticles-based co-delivery of black phosphorus quantum dots and melphalan by photothermal therapy combined with chemotherapy for retinoblastoma

Wang, Shijing; Wei, Pengxue; Zhang, Yujun; Zhang, Shaochong

doi:10.1016/j.polymertesting.2023.108292

Cited by 7 publications

(1 citation statement)

References 55 publications

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“…One interesting finding is that free BPQDs were more cytotoxic than those loaded in nanoparticles, which is optimal for mitigating their toxic side effects, such as nephrotoxicity. In fact, BPQDs alone induced the highest inhibitory effect, at 79%, but they showed the highest ki67 levels, which were reduced in co-loaded LNPs [62,63]. As mentioned previously, ongoing research to optimize the formulation of LNPs only or within a combination therapy is needed to better understand the characteristics and changes in the structure and function, which loading of different elements may cause.…”

Section: Lipid Nanoparticlesmentioning

confidence: 94%

Advancements in Nanosystems for Ocular Drug Delivery: A Focus on Pediatric Retinoblastoma

Wu,

Wang,

Anderson

et al. 2024

Molecules

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The eye’s complex anatomical structures present formidable barriers to effective drug delivery across a range of ocular diseases, from anterior to posterior segment pathologies. Emerging as a promising solution to these challenges, nanotechnology-based platforms—including but not limited to liposomes, dendrimers, and micelles—have shown the potential to revolutionize ophthalmic therapeutics. These nanocarriers enhance drug bioavailability, increase residence time in targeted ocular tissues, and offer precise, localized delivery, minimizing systemic side effects. Focusing on pediatric ophthalmology, particularly on retinoblastoma, this review delves into the recent advancements in functionalized nanosystems for drug delivery. Covering the literature from 2017 to 2023, it comprehensively examines these nanocarriers’ potential impact on transforming the treatment landscape for retinoblastoma. The review highlights the critical role of these platforms in overcoming the unique pediatric eye barriers, thus enhancing treatment efficacy. It underscores the necessity for ongoing research to realize the full clinical potential of these innovative drug delivery systems in pediatric ophthalmology.

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Section: Lipid Nanoparticlesmentioning

confidence: 94%