Lipid nanovesicles for biomedical applications: ‘What is in a name’?

Apolinário, Alexsandra Conceição; Hauschke, Leon; Nunes, Jessica Ribeiro; Lopes, Luciana B.

doi:10.1016/j.plipres.2021.101096

Cited by 59 publications

(31 citation statements)

References 285 publications

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“…They were macroscopically characterized as single phase, transparent, isotropic, and fluid formulations. , The selection of tricaprylin was based on its ability to dissolve lipophilic drugs like fenretinide and the acceptable safety profile . In addition to its ability to form liquid-crystalline phases, PC was selected due to its biocompatibility, which implicates in low irritation potential. , …”

Section: Methodsmentioning

confidence: 99%

“…31 In addition to its ability to form liquid-crystalline phases, PC was selected due to its biocompatibility, which implicates in low irritation potential. 31,38 PC and tricaprylin (T) (9:1, w/w) were vortex-mixed (Genie 2, Scientific Industries, Bohemia, NY) and heated at 50 °C in a water bath. Subsequently, PG was added to the PCT mixture at 40 and 50%, forming two MEs: ME 9:1−40% and ME 9:1−50% were composed of PC/T/PG at 54:6:40 and 45:5:50 (w/w/w), respectively.…”

Section: Non-aqueous Me Development and Phasementioning

confidence: 99%

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Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development

et al. 2021

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The need of pharmacological strategies to preclude breast cancer development motivated us to develop a non-aqueous microemulsion (ME) capable of forming a depot after administration in the mammary tissue and uptake of interstitial fluids for prolonged release of the retinoid fenretinide. The selected ME was composed of phosphatidylcholine/tricaprylin/propylene glycol (45:5:50, w/w/w) and presented a droplet diameter of 175.3 ± 8.9 nm. Upon water uptake, the ME transformed successively into a lamellar phase, gel, and a lamellar phase-containing emulsion in vitro as the water content increased and released 30% of fenretinide in vitro after 9 days. Consistent with the slow release, the ME formed a depot in cell cultures and increased fenretinide IC50 values by 68.3- and 13.2-fold in MCF-7 and T-47D cells compared to a solution, respectively. At non-cytotoxic concentrations, the ME reduced T-47D cell migration by 75.9% and spheroid growth, resulting in ∼30% smaller structures. The depot formed in vivo prolonged a fluorochrome release for 30 days without producing any sings of local irritation. In a preclinical model of chemically induced carcinogenesis, ME administration every 3 weeks for 3 months significantly reduced (4.7-fold) the incidence of breast tumors and increased type II collagen expression, which might contribute to limit spreading. These promising results support the potential ME applicability as a preventive therapy of breast cancer.

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Section: Methodsmentioning

confidence: 99%

Section: Non-aqueous Me Development and Phasementioning

confidence: 99%

Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development

et al. 2021

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“…Their appeal stems from their applicability as nanocarriers for drug delivery, in modeling cell mimicking studies, and supporting theories on the origins of life. [ 176–178 ] The success in these fields can be attributed to several factors, including their ability to: (i) encapsulate hydrophilic/hydrophobic drugs, (ii) functionalize their surface for targeted applications, and (iii) easily manipulate their composition to produce rigid or flexible vesicles depending on the intended use [171] . These benefits are translatable for H 2 S sensing in biological settings and enable formerly impracticable applications, as previously shown [179] .…”

Section: H2s Detection By Nanomaterial‐based Probesmentioning

confidence: 99%

Synthetic nanoprobes for biological hydrogen sulfide detection and imaging

Zhou

Mazur

Fan

et al. 2022

VIEW

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Hydrogen sulfide (H2S) is a gaseous molecule involved in multiple biological and physiological processes, including various diseases such as cancer and neurodegenerative disorders. This has led to the development of various analytical methods to monitor H2S in biological settings. Among these, fluorescence‐based assays, specifically organic small‐molecule probes, have been thoroughly utilized. They offer good sensitivity and specificity as sensors, and noninvasive detection with high spatiotemporal resolution in in vitro and in vivo imaging. Despite attempts to decrease the rate of photobleaching and enhance the photostability of these dyes, they are still limited by low survival time and complex reagent pretreatment. Fortunately, nanotechnology has been applied to develop effective, highly sensitive, and specific fluorescent nanoprobes. Specifically, nanomaterial‐based H2S probes have emerged as promising candidates for real‐time detection and imaging. In contrast to their organic molecule‐based counterparts, they offer higher versatility in imaging modes due to their unique optical properties, improved photostability and solubility within physiological fluids, as well as easily modifiable surfaces and tuneable structures for improved specificity. Recently, many nanomaterial‐based probes, ranging from inorganic nanoparticles to self‐assembled nanocomposites, have been developed. These have, for the most part, achieved sensitive and specific endogenous H2S detection and in vivo imaging. In this review, we evaluate five different nanomaterials currently being researched to detect and image endogenous H2S within the last 5 years. Furthermore, analytical methods associated with the various signal outputs, current challenges in H2S nanoprobe design, and possible future research interests are outlined and discussed.

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“…Promising strategy is the functionalization of liposomes with surfactants, which allows for controlling the size, shape and charge characteristics of vesicular nanocarriers, improving drug loading, overcoming the biological barriers, etc. [29][30][31][32][33][34][35][36]. Key factors that should be considered upon the modification are the nature of surfactant head group, hydrophobicity and presence of unsaturated C-C bonds in alkyl chains, and lipid/surfactant ratio [29].…”

Section: Lipid Nanocarriers Modified With Amphiphilic Moleculesmentioning

confidence: 99%

“…It was demonstrated that surfactants are capable of irreversible integration with lipid bilayer far beyond their critical micellar concentration due to lateral interactions [30], thereby markedly changing surface characteristics of liposomes. Surfactant-modified vesicles exhibit essentially improved physicochemical properties and functionality, which in some cases resulted in the isolation of special types of flexible or elastic (deformable) vehicles with enhanced skin permeability, the so-called transferosomes [26,[31][32][33], and alternative carriers, niosomes [35].…”

Section: Lipid Nanocarriers Modified With Amphiphilic Moleculesmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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Lipid nanovesicles for biomedical applications: ‘What is in a name’?

Cited by 59 publications

References 285 publications

Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development

Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development

Synthetic nanoprobes for biological hydrogen sulfide detection and imaging

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

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