2012
DOI: 10.1161/atvbaha.112.255711
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Lipid Oxidation in Carriers of Lecithin:Cholesterol Acyltransferase Gene Mutations

Abstract: Objective Lecithin:cholesterol acyltransferase (LCAT) has been shown to play a role in the depletion of lipid oxidation products, but this has so far not been studied in humans. In this study, we investigated processes and parameters relevant to lipid oxidation in carriers of functional LCAT mutations. Methods and Results In 4 carriers of 2 mutant LCAT alleles, 63 heterozygotes, and 63 family controls, we measured activities of LCAT, paraoxonase 1, and platelet-activating factor-acetylhydrolase; levels of ly… Show more

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Cited by 27 publications
(13 citation statements)
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“…Circulating levels of PAF-AH is also shown to be an independent marker of the risk of CAD ( 81 ). However, in a recent study by Holleboom et al ( 82 ), reduced LCAT activity and PAF-AH activity due to LCAT mutations was not associated with increased plasma lipid peroxidation.…”
Section: Effects Of Hdl On Enos-dependent No Productionmentioning
confidence: 80%
“…Circulating levels of PAF-AH is also shown to be an independent marker of the risk of CAD ( 81 ). However, in a recent study by Holleboom et al ( 82 ), reduced LCAT activity and PAF-AH activity due to LCAT mutations was not associated with increased plasma lipid peroxidation.…”
Section: Effects Of Hdl On Enos-dependent No Productionmentioning
confidence: 80%
“…Furthermore, LCAT can work as a chain-breaking antioxidant via its Cys residues at the positions 31 and 184 [109] . There is evidence that mutations in LCAT may reduce antioxidative capacity of HDL [110] . However, these mutations were not associated with increased concentrations of lipid peroxidation products in plasma [110] .…”
Section: Molecular Components Of Hdl Contributing To Its Antioxidativmentioning
confidence: 99%
“…Similarly, there is currently limited evidence to support a role for LCAT in the antioxidative activity of HDL (Holleboom et al, 2012 ), but its association with HDL and, like PON1 and PLA2, its role in generating lysophospholipids, does contribute to the hypothesis that HDL provides a safe place to release lysolipids otherwise potentially damaging to cell membranes and other lipoproteins.…”
Section: Lecithin: Cholesterol Acyl Transferasementioning
confidence: 99%