Lipid peroxidation and atherosclerosis in type II diabetes

Oranje, W.A.; Wolffenbuttel, Bruce H. R.

doi:10.1016/s0022-2143(99)90050-1

Cited by 41 publications

(32 citation statements)

References 171 publications

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“…Hyperglycemia and hyperinsulinemia increase the production of free radicals (26). Oxidatively modified LDL seems to have the main role in the initiation of atherogenesis (27,28), and there is evidence that lipid peroxidation is increased in type 2 diabetic patients (29,30). Diets rich in antioxidants have been associated with antiatherogenic properties (28).…”

Section: Results -mentioning

confidence: 99%

Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 Diabetes

Marniemi²,

et al. 2007

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OBJECTIVE -Low serum zinc level may predispose nondiabetic subjects to cardiovascular diseases. Our aim was to investigate whether serum zinc level predicts coronary heart disease (CHD) events in subjects with type 2 diabetes RESEARCH DESIGN AND METHODS -The original study population consisted of 1,059 patients with type 2 diabetes, aged 45-64 years. Mean duration of diabetes was 8 years.Serum zinc values were available from 1,050 subjects. CHD mortality and the incidence of nonfatal myocardial infarction (MI) were assessed in a 7-year follow-up.RESULTS -During the follow-up, 156 patients died from CHD and 254 patients had a fatal or nonfatal MI. Patients with serum zinc concentration Յ14.1 mol/l at baseline had a higher risk for death from CHD than patients with serum zinc level Ͼ14.1 mol/l (20.8 and 12.8%, respectively; P ϭ 0.001) The risks for fatal or nonfatal MI were 30.5 and 22.0%, respectively (P ϭ 0.005). In Cox regression analyses, low serum zinc concentration was significantly associated with CHD mortality (relative risk [RR] 1.7, P ϭ 0.002) and all CHD events (RR 1.37, P ϭ 0.030), even after adjustment for confounding variables.CONCLUSIONS -In this large cohort of type 2 diabetic patients, low serum zinc level was an independent risk factor for CHD events. Diabetes Care 30:523-528, 2007C oronary heart disease (CHD) is a major cause of death in type 2 diabetic patients, and the risk of CHD is two-to fourfold higher among patients with type 2 diabetes than in nondiabetic subjects. This enhanced risk is partly explained by traditional risk factors, e.g., hypertension, plasma lipid and lipoprotein abnormalities, smoking, and obesity, but all of the excess risk cannot be explained by these conventional risk factors. Nontraditional risk factors may be important in the pathogenesis of CHD in patients with type 2 diabetes.Because serum zinc is a micronutrient with known antioxidant activity (1), it might be relevant to assess its role in the atherogenesis in type 2 diabetes. Patients with diabetes have lower serum levels of zinc (2).In nondiabetic subjects there are studies suggesting that low serum level of zinc is associated with increased incidence of cardiovascular disease (3-5). To our knowledge, there are no studies in type 2 diabetic patients on the association between low serum levels of zinc and cardiovascular events. In this large prospective study with type 2 diabetic patients, we examined the association between serum zinc level and CHD events. RESEARCH DESIGN AND METHODSBaseline study A detailed description of study participants has been given elsewhere (6). Patients with type 2 diabetes, aged 45-64 years, who were born and living in the Turku University Central Hospital district in West Finland or in the Kuopio University Hospital district in East Finland were identified through a national drug reimbursement register. The final population consisted of 1,059 type 2 diabetic subjects. Of these, 328 men and 221 women were from West Finland (participation rate 79%), and 253 men and 257 women were fr...

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Section: Results -mentioning

confidence: 99%

Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 Diabetes

Marniemi²,

et al. 2007

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“…[11,12] With regards to LDL oxidizability in Type 2 Diabetes Mellitus (T2DM), studies to date show divergent results, due to the heterogeneity of the diabetic populations, glycemic control, age and the presence of vascular complications. [13] While some studies have not found increased susceptibility of LDL to oxidation in diabetic subjects, evidence for increased LDL oxidizability in diabetic subjects has been shown in at least five studies. [13] Also, T2DM has small, dense LDL, which is more prone to oxidation than large, buoyant LDL.…”

Section: Introductionmentioning

confidence: 99%

“…[6,7] The most common antioxidant deficiencies reported in diabetes are lower levels of ascorbate, glutathione and superoxide dismutase. [13] Lower concentrations of reduced glutathione have been documented in diabetic neutrophils and monocytes. The most common antioxidant deficiency that has been reported in diabetes is lower concentrations of ascorbate in both diabetic plasma and mononuclear cells.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress, Inflammation, and Diabetic Vasculopathies: The Role of Alpha Tocopherol Therapy

Jialal¹,

Devaraj²,

Venugopal³

2002

Free Radical Research

125

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The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress and inflammation in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation (e.g. increased F2-isoprostanes) and increased DNA damage. Evidence for increased inflammation includes increased monocyte superoxide and pro-inflammatory cytokine release (IL-1, IL-6, and TNF-alpha), increased monocyte adhesion to endothelium and increased levels of plasma C-reactive protein, the prototypic marker of inflammation. Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality.

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“…Several investigators have found an increase in serum lipid peroxide leves, antibody titer against oxidized LDL (oxLDL-Ab), and the susceptibility of LDL or very low-density lipoproteins (VLDL+LDL) to lipid peroxidation in patients with some atherosclerotic risk factors, such as hypercholesterolemia [7,8], diabetes mellitus [9,10], essential hypertension [11,12], aging [13], and those with atherosclerosis [5,6,9,[14][15][16][17]. On the other hand, some restricted experimental [18,19] and clinical evidence [20][21][22][23][24] has suggested that pro-oxidant-antioxidant balance was also affected in obesity.…”

Section: Introductionmentioning

confidence: 99%

An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Mutlu-Türkoglu¹,

Öztezcan²,

Telci³

et al. 2003

Clinical and Experimental Medicine

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Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoproteincholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoproteincholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.

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Lipid peroxidation and atherosclerosis in type II diabetes

Cited by 41 publications

References 171 publications

Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 Diabetes

Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 Diabetes

Oxidative Stress, Inflammation, and Diabetic Vasculopathies: The Role of Alpha Tocopherol Therapy

An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

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