Lipid peroxidation and cancer

Dianzani, Mario U.

doi:10.1016/1040-8428(93)90052-6

Cited by 107 publications

(46 citation statements)

References 160 publications

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“…57 Finally, different grades of the tumors studied with a low lipoperoxydation level have also been related to better proliferative potential. 58 In the case of the carcinogenic effect of HNE as an exogenous compound, during the promotion of colorectal carcinogenesis by heme iron, HNE has been shown to be produced in the colon lumen. It has been shown that normal cells are highly sensitive to HNE, whereas preneoplastic cells are resistant.…”

Section: Hne and Diseases Associated With Oxidative Damage: Links To mentioning

confidence: 99%

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

et al. 2013

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During the last three decades, 4-hydroxy-2-nonenal (HNE), a major a,b-unsaturated aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great number of pathologies such as metabolic diseases, neurodegenerative diseases and cancers. These multiple pathologies can be explained by the fact that HNE is a potent modulator of numerous cell processes such as oxidative stress signaling, cell proliferation, transformation or cell death. The main objective of this review is to focus on the different aspects of HNE-induced cell death, with a particular emphasis on apoptosis. HNE is a special apoptotic inducer because of its abilities to form protein adducts and to propagate oxidative stress. It can stimulate intrinsic and extrinsic apoptotic pathways and interact with typical actors such as tumor protein 53, JNK, Fas or mitochondrial regulators. At the same time, due to its oxidant status, it can also induce some cellular defense mechanisms against oxidative stress, thus being involved in its own detoxification. These processes in turn limit the apoptotic potential of HNE. These dualities can imbalance cell fate, either toward cell death or toward survival, depending on the cell type, the metabolic state and the ability to detoxify.

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Section: Hne and Diseases Associated With Oxidative Damage: Links To mentioning

confidence: 99%

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

et al. 2013

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“…In human renal cell carcinoma, immunohistochemistry for HNE-modified proteins showed positive staining in the cytoplasm of tumor cells, with respect to controls, without correlation to the clinical stage (Okamoto et al, 1994). However other reports have demonstrated the opposite: a low or undetectable lipid peroxidation, as well as HNE content, such as in hepatomas (Dianzani, 1993). Several studies have shown elevated lipid peroxidation markers in the sera, plasma or urine of breast carcinoma (Hung et al, 1999;Chandramathi et al, 2009), cervical intraepithelial neoplasia and carcinoma of the cervix (Looi et al, 2008), head and neck squamous cell carcinoma (Gupta et al, 2009) and prostate tumor (Kotrikadze et al, 2008), compared to healthy controls.…”

Section: Hne Content In Human Cancersmentioning

confidence: 90%

Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News

Pizzimenti¹,

Toaldo²,

Pettazzoni³

et al. 2012

Colorectal Cancer Biology - From Genes to Tumor

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“…On the contrary, once transformed, cancer cells become generally resistant to oxidative stress and their susceptibility to lipid peroxidation decreases. Major reasons for this behavior are an increased cholesterol-dependent rigidity and a decreased availability of the peroxidative substrates arachidonic and linoleic acids in tumor membranes [25].…”

Section: Colon Cancermentioning

confidence: 99%

TGFβ1 expression in colonic mucosa: modulation by dietary lipids

2007

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Transforming growth factor beta1 (TGFb1) is fundamental to maintain the intestinal epithelial cell homeostasis through its control action on cell proliferation, differentiation and apoptosis. TGFb1 dysregulation has been observed in several chronic human diseases, including ulcerative colitis, Crohn's disease and colon carcinoma. In the first two conditions, a marked oxidative stress is consistently present, while in the third one, levels of reactive oxygen species tend to be significantly lower than in the surrounding normal tissue. Lipid-derived compounds such as the aldehyde 4-hydroxynonenal (HNE) or cholesterol oxidation products (oxysterols) were shown able to induce expression and synthesis of TGFb1, an event which can be detrimental or beneficial, essentially depending on its actual intensity. Understanding how specific dietary lipids may influence the complex molecular signaling underlying this cytokine expression, may provide new indications for therapeutic and preventive strategies in inflammatory bowel diseases and colon carcinoma.

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Lipid peroxidation and cancer

Cited by 107 publications

References 160 publications

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News

TGFβ1 expression in colonic mucosa: modulation by dietary lipids

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