Lipid Peroxidation and Glutathione Peroxidase Activity in Patients With Copd: Relationship to Disease Severity

Tkáčová, Ružena; Petrášová, Darina; Kluchová, Zuzana; Joppa, Pavol; Klimcik, Roman; Dorková, Zuzana

doi:10.1378/chest.128.4_meetingabstracts.131s-a

Cited by 3 publications

(2 citation statements)

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“…COPD patients show increased levels of lipid peroxidation products such as F2-isoprostanes, 4-hydroxynonenal and MDA, especially during exacerbation. 22,23 Herein, MDA serum concentrations were initially similar to those in healthy subjects, but then rose significantly until discharge. TOS values increased constantly during hospitalisation and were proportional to other oxidative stress markers, which could imply general oxidative stress fluctuations of other measured markers.…”

Section: Discussionmentioning

confidence: 69%

“…Rahman et al measured changes in TAS values in COPD patients from the point of exacerbation to discharge as in our study, but instead they found elevated TAS values (opposite to our results). 22 This could be explained by different therapeutic approaches. The above-mentioned study included patients treated with corticosteroids for a week before admission to hospital; we examined only previously untreated patients.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

Stanojkovic¹,

Kotur‐Stevuljević²,

Milenković³

et al. 2011

Respiratory Medicine

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

Stanojkovic¹,

Kotur‐Stevuljević²,

Milenković³

et al. 2011

Respiratory Medicine

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Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease

Arja

Surapaneni

Raya³

et al. 2013

Respirology

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The role of oxidative stress in lung injury induced by cigarette smoke

Kluchová

Tkáčová

2006

Biologia

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Oxidative stress is a damaging process resulting from an imbalance between excessive generation of oxidant compounds and insufficient antioxidant defence mechanisms. Oxidative stress plays a crucial role in the initiation and progression of cigarette smoke-induced lung injury, deterioration in lung functions, and development of chronic obstructive pulmonary disease (COPD). In smokers and in patients with COPD, the increased oxidant burden derives from cigarette smoke per se, and from activated inflammatory cells releasing enhanced amounts of reactive oxygen and nitrogen species (ROS, RNS, respectively). Although mild oxidative stress resulting from cigarette smoking leads to the upregulation of the antioxidative enzymes synthesis in the lungs, high levels of ROS and RNS observed in patients with COPD overwhelm the antioxidant enzymes capacities, resulting in oxidant-mediated lung injury and cell death. In addition, depletion of antioxidative systems in the systemic circulation was consistently observed in such patients. The imbalance between the generation of ROS/RNS and antioxidant capacities -the state of "oxidative stress" -is one of the major pathophysiologic hallmarks in the development of COPD. Detrimental effects of oxidative stress include impairment of membrane functions, inactivation of membrane-bound receptors and enzymes, and increased tissue permeability. In addition, oxidative stress aggravates the inflammatory processes in the lungs, and contributes to the worsening of the protease-antiprotease imbalance. Several markers of oxidative stress, such as increases in lipid peroxidation products and reductions in glutathione peroxidase activity, have been shown to be related to the reductions in pulmonary functions. In the present article we review the current knowledge about the vicious cycle of cigarette smoking, oxidative stress, and inflammation in the pathogenesis of COPD.

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Lipid Peroxidation and Glutathione Peroxidase Activity in Patients With Copd: Relationship to Disease Severity

Cited by 3 publications

References 0 publications

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease

The role of oxidative stress in lung injury induced by cigarette smoke

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