Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation

Boujelben, Maissa; Ghorbel, Fatma; Vincent, Christian; Makni‐Ayadi, Fatma; Guermazi, F.; Croute, F.; El-Feki, Abelfettah

doi:10.1016/j.etp.2006.02.012

Cited by 44 publications

(27 citation statements)

References 33 publications

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“…In addition, magnesium supplements diminished the body weight losses resulting from cadmium administration. The beneficial action of magnesium on the relative weight of testicles may be in accordance with the results of Djukic-Cosic et al (5) who found that magnesium stimulates production of glutathione (GSH) de novo, which indicates a protective role of magnesium against the toxic action of cadmium and a magnesiummitigated decrease in lipid peroxidation produced by cadmium (2).…”

Section: Discussionsupporting

confidence: 77%

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Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Grosicki

Małagocki

Kycko

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The importance of magnesium supplements on organ retention of cadmium and allometric parameters after repeated exposure to cadmium chloride were studied in male Wistar rats. Magnesium chloride was given via drinking water (500 mg Mg/L) to rats exposed intragastrically to cadmium chloride (labelled with cadmium 109) at a daily dose corresponding to 25 mg/kg diet for 7, 14, 21, and 28 d. Supplements of magnesium temporarily decreased cadmium retention in the duodenum and liver. No significant differences in cadmium retention were evidenced in the kidneys and testicles. The supplements of magnesium also retain more of the body weight gains and restore the relative liver and testicle weight in rats intoxicated with cadmium. Comparison of the present results with earlier reports suggests a relationship between doses of magnesium and cadmium; higher doses of cadmium need more magnesium to overcome toxic action of the heavy metal.

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Section: Discussionsupporting

confidence: 77%

“…Research on the effects of nutrients on the bioavailability of cadmium has produced growing evidence for the beneficial role of selenium, calcium, zinc, and iron, and dietary ingredients in reducing cadmium uptake and toxicity (2,4,8,11,13,16,17,18,22,23).…”

Section: Introductionmentioning

confidence: 99%

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Grosicki

Małagocki

Kycko

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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“…Boujelben et al (73) showed that Mg supplementation could reduce both organ Cd accumulation and Cd-related LPO. The authors found that parenteral Mg supplementation (in form of sulphate) was associated with a dosedependent reduction in Cd levels in rat kidney, liver, and testis and lowered Cd-induced LPO in the liver and kidney.…”

Section: Magnesium and Cadmium Interactionmentioning

confidence: 99%

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Matović

Buha

Bulat

et al. 2011

Archives of Industrial Hygiene and Toxicology

183

122

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Discovered in late 1817, cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to fi nd out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically effi cient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has benefi cial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These fi ndings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

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“…Dong et al (2001) indicated that Cd treatment induced increases in secretion of such cytokines (and other chemokines) by monocytes and Kupffer cells. Because pro-inflammatory cytokines activate inflammatory cells to release large amounts of reactive oxygen species, it is not surprising that Cd exposure is associated with severe oxidant damage (Boujelben et al, 2006), even though the metal itself is not redox-active per se.…”

Section: Immunoglobulin µG/mlmentioning

confidence: 99%

Tunisian radish (Raphanus sativus) extract prevents cadmium-induced immunotoxic and biochemical alterations in rats

Salah-Abbès

Abbès

Haous

et al. 2014

Journal of Immunotoxicology

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Cadmium (Cd), a known carcinogen and potent immunotoxicant in humans and animals, is dispersed throughout the environment as a result of pollution from a variety of sources. Tunisian radish (Raphanus sativus) extract (TRE) is a known anti-oxidant and free radical scavenger that has been shown to help alleviate immune system disorders, including some induced by environmental toxicants. The present study was undertaken to investigate potential protective effects of TRE against Cd-induced immunotoxicities (and general toxicities) in situ. Cadmium chloride (at 2.5 mg CdCl 2 /kg BW) and TRE (5, 10, or 15 mg/kg BW) were given (alone or in combination [actually, in sequence of Cd and then TRE]) to rats daily by oral gavage for 2 weeks. Results indicated that treatment with CdCl 2 alone resulted in significant decreases in plasma levels of total protein, triglycerides, creatine kinase, creatinine, IgG and IgA, T-lymphocyte sub-types (CD4 + , CD3 + , CD56 + , and CD8 + ), and in thymic and hepatic indices (relative weights). In contrast, CdCl 2 treatment caused significant increases in serum LDH, AST, and ALT, in the formation/release of pro-inflammatory cytokines (IL-1 and TNF), and in the relative weights of host spleen and kidneys. Rats treated with TRE alone had no discernable changes compared to the controls with regard to all test parameters. Combined treatment of CdCl 2 and TRE-at any dose-resulted in a significant improvement of all test parameters compared to those seen with Cd alone. These results illustrated (and provided further support for a continuing belief in) the beneficial effects of TRE in reducing the harmful outcomes of commonly encountered toxicants (like Cd) on the immune system and on overall host health status.

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Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation

Cited by 44 publications

References 33 publications

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Magnesium supplements affect selected cadmium toxic actions and uptake of repeated doses of cadmium

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Tunisian radish (Raphanus sativus) extract prevents cadmium-induced immunotoxic and biochemical alterations in rats

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