Lipid peroxidation and total antioxidant status in patients with breast cancer

Abstract

Oxidative stress is considered to be involved in the pathophysiology of all cancers. The aim of this study is to examine oxidative stress and antioxidant status in patients with breast cancer by evaluation of the serum levels of total antioxidant capacity (TAC) and lipid peroxidation products as malondialdehyde (MDA) and lipid hydroperoxide and to investigate the relationship between these parameters, oxidative stress and serum lipids and lipoproteins. In our study, serum TAC, MDA, lipid hydroperoxide, HDL-cholesterol, VLDL-cholesterol, LDL-cholesterol, total cholesterol, triacylglycerol (TAG), albumin and uric acid levels of 56-breast cancer patients in different clinical stages and 18 healthy women were determined. Significantly lower-levels of TAC were detected in patients with breast cancer in comparison to controls (2.01 +/- 0.01 mmol/l and 2.07 +/- 0.03 mmol/l, respectively, p < 0.05). Serum MDA levels of the patients were higher compared to the controls (3.64 +/- 0.25 microM and 2.72 +/- 0.22 microM, respectively, p < 0.05). No significant difference between lipid hydroperoxide levels of patients and controls was found (0.33 +/- 0.05 microM and 0.32 +/- 0.01 microM, respectively, p > 0.05). These data show that lower TAC and higher MDA levels i.e. increased oxidative stress may be related to breast cancer.

The 8‐epimer of prostaglandin F2α, a marker of lipid peroxidation and oxidative stress, is decreased in the nipple aspirate fluid of women with breast cancer

“…8 Several studies have found enhanced lipid peroxidation and depletion of antioxidants in the plasma of BC patients, suggesting that increased oxidative stress may be related to human breast carcinogenesis. [9][10][11][12][13] Moreover, an increased content of lipid peroxidation products was found in BC tissue, supporting the hypothesis of breast tumorigenesis by in situ oxidative stress. 14,15 On the other hand, recent reports suggest that lipid peroxidation may represent a protective mechanism in BC through the induction of apoptosis, thereby maintaining the balance between breast epithelial cell growth and death, 8,16 supporting the hypothesis that lipid peroxidation in tissue of benign breast disease (BBD) is greater than in BC.…”

“…Although several lipid peroxidation products have been previously identified in plasma and tissues of women with breast disease, as well as in human milk, [9][10][11][12][13][14][15][16]23,24 we report for the first time the detection of both MDA and 8-iso-PGF 2a , 2 major indexes of lipid peroxidation and oxidative stress, in NAF from healthy women and patients with BC. [4][5][6][7] We found that breast milk from healthy women contains lower levels of MDA than matched plasma, postulating that this difference may be related to different metabolism of free fatty acids (e.g.…”

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

“…However, the salivary concentrations of TAC and MDA in the PTC patients were respectively lower and higher compared to the control subjects. Consistent with our findings, Sener et al reported significantly lower levels of TAC in breast cancer patients compared to the control group (17). Furthermore, Hosseini-Zijoud et al demonstrated significantly lower TAC concentrations in the patients medullary thyroid cancer compared to healthy controls, which could be due to the consumption of antioxidants as a result of augmented metabolism and production of free radicals (8).…”

Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients

“…Several reports exist that reveal increases in MDA concentration in patients presenting neoplasm (Thangaraju et al 1994;Ray et al 2000;Sener et al 2007). It has also been reported that lipid peroxidation in breast cancer tissues was enhanced compared to nonmalignant tissues (Tas et al 2005).…”

“…Analysis of data obtained by Sener et al (2007) showed that lower total antioxidant capacity and higher malondialdehyde (MDA) levels increased oxidative stress and could be related to breast cancer.…”