Lipid Peroxidation and Variation of Antioxidant Enzymes and Vitamins in Malaria Infected Pregnant Women

Tiyong, Serge Herve Ifoue; Gouado, Inocent; Teugwa, Clautilde Mofor; Zollo, Paul Henri Amvam

doi:10.1016/j.freeradbiomed.2010.10.491

Cited by 1 publication

(6 citation statements)

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“…The findings across several studies denote a marked decrease in TAS levels in patients with malaria compared to non-malaria cases. This trend was observed in several studies [ 15 , 17 , 26 , 27 , 29 , 32 , 33 , 35 , 37 – 42 ]. Furthermore, some studies also identified a negative association between TAS levels and parasite density [ 17 , 33 , 40 ].…”

Section: Resultssupporting

confidence: 73%

“…Others were excluded because they lacked abstracts, were letters or conference abstracts, or were non-original articles such as systematic reviews, case reports, or commentaries. After these exclusions, a total of 13 studies were retrieved from the main databases [ 15 – 17 , 26 – 35 ]. This list was supplemented with six studies from Google Scholar [ 36 – 41 ] and one additional study identified from a reference list [ 42 ], bringing the total to 20 studies [ 15 – 17 , 26 – 42 ] (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A few studies had exposure periods long enough to be meaningful [ 15 , 37 , 38 ], but not all. Eight cross-sectional studies generally met the following criteria [ 16 , 17 , 30 , 31 , 34 – 36 , 39 ], but one study lacked a detailed setting description [ 39 ], and some studies did not report on confounding factors or provide explicit strategies to address them [ 17 , 30 , 31 , 35 , 36 , 39 ]. A cohort study lacked strategies to deal with confounding factors and to address incomplete follow-up [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, two studies [ 16 , 34 ] found no significant difference in TAS levels between various patient groups and controls. Lastly, three studies on pregnant women showed diverse results [ 31 , 35 , 36 ]. Tiyong Ifoue et al .…”

Section: Resultsmentioning

confidence: 99%

“…Tiyong Ifoue et al . observed fluctuating TAS levels during different trimesters in pregnant women with malaria [ 35 ]. Mahamat et al .…”

Section: Resultsmentioning

confidence: 99%

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Total antioxidant status levels in malaria: a systematic review and meta-analysis

Kotepui,

Mahittikorn,

Mala

et al. 2024

Malar J

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Background Malaria, a severe health threat, significantly affects total antioxidant status (TAS) levels, leading to considerable oxidative stress. This systematic review and meta-analysis aimed to delineate differences in TAS levels between malaria patients and healthy controls, and assess correlations between disease severity and parasite density. Methods The systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42023448761. A comprehensive literature search was conducted in databases such as Embase, MEDLINE, Journals@Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify studies reporting data on TAS levels in malaria patients. Data from the included studies were analysed both qualitatively and quantitatively. Differences in TAS levels between malaria patients and controls were pooled using a random effects model, with Hedges' g as the effect size measure. Results Of 1796 identified records, 20 studies met the inclusion criteria. The qualitative synthesis of these studies revealed a marked decrease in TAS levels in patients with malaria compared to non-malaria cases. The meta-analysis results showed a significant decrease in TAS levels in patients with malaria compared to non-malaria cases (P < 0.01, Hedges’ g: − 2.75, 95% CI − 3.72 to −1.78, I2: 98.16%, 13 studies), suggesting elevated oxidative stress in these patients. Subgroup analyses revealed that TAS level variations were significantly influenced by geographical region, age group, Plasmodium species, and method for measuring TAS. Notably, TAS levels were significantly lower in severe malaria cases and those with high parasite density, indicating a potential relationship between oxidative stress and disease severity. Conclusion This study highlights the potential utility of TAS as a biomarker for disease risk and severity in malaria. The significant decrease in TAS levels in malaria patients compared to controls implies increased oxidative stress. Further well-designed, large-scale studies are warranted to validate these findings and elucidate the intricate mechanisms linking TAS and malaria.

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