Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease

Mas-Bargues, Cristina; Escrivá, C.; Dromant, Mar; Borrás, Consuelo; Viña, José

doi:10.1016/j.abb.2021.108941

Cited by 193 publications

(126 citation statements)

References 53 publications

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“…The initial mean GDF15 and FGF21 values of patients with CO poisoning were higher in this study than in our previous study on healthy adult volunteers (GDF15: 1.92 vs. 0.73 ng/mL; FGF21: 2.02 vs. 0.42 ng/mL) [ 20 ]. In addition, indirect comparisons of the 8-OHdG and MDA values from the patients in this cohort and that of other studies [ 43 , 44 ] revealed an increase in 8-OHdG and MDA in these patients (8-OHdG: 29.2 vs. 25.5 pg/mL; MDA: 2.02 vs. 1.25 nmol/mL). Elevated serum biomarkers in the early stages of CO poisoning demonstrate that acute CO exposure induces mitochondrial and oxidative stress.…”

Section: Discussionsupporting

confidence: 64%

Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning

et al. 2022

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Mitochondrial and oxidative stress play critical roles in the pathogenic mechanisms of carbon monoxide (CO)-induced toxicity. This study was designed to evaluate whether the serum levels of specific stress biomarkers might reflect brain injury and act as prognostic markers for the development of neurocognitive sequelae following CO poisoning. We analyzed the data from 51 adult patients admitted with acute CO poisoning and measured the serum level expression of growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21), indicators of mitochondrial stress, and 8-Oxo-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), indicators of oxidative stress. Serum was collected upon arrival at the hospital, at 24 h post treatment, and within 7 days of HBO2 therapy. Global Deterioration Scale scores were measured 1 month post incident and used to place the patients in either favorable or poor outcome groups. Initial serum GDF15 and 8-OHdG concentrations were significantly increased in the poor-outcome group and all four biomarkers decreased at 24 h post HBO2 therapy, and were then maintained or further decreased at the 1-week mark. Notably, the degree of change in these biomarkers between baseline and 24 h post HBO2 were significantly larger in the poor-outcome group, reflecting greater CO-associated stress, confirming that post-CO poisoning serum biomarker levels and their response to HBO2 were proportional to the initial stress. We suggest that these biomarkers accurately reflect neuronal toxicity in response to CO poisoning, which is consistent with their activity in other pathologies.

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Section: Discussionsupporting

confidence: 64%

Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning

et al. 2022

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“…Kang R et al [ 35 ] described that lipid peroxidation in ferroptosis induces pyroptosis, suggesting a link between ferroptosis and other forms of cell death in sepsis. Lipid peroxidation is involved in several disease conditions [ 36 ] like cardiovascular disease [ 37 ] cancer [ 38 ], Alzheimer [ 39 ] and chronic diseases such as NAFLD [ 40 ], Multiple Sclerosis [ 41 ], COPD [ 42 ] and Diabetes mellitus [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Lipid peroxidation as a hallmark of severity in COVID-19 patients

et al. 2021

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“…The oxidation products are categorized into primary and secondary products. Critical criteria for detecting lipid oxidation include accuracy, precision, sensitivity, and detection limits [30,31]. Either direct or indirect methods determine lipid oxidation in foods.…”

Section: Introductionmentioning

confidence: 99%

Analytical Methods for Lipid Oxidation and Antioxidant Capacity in Food Systems

2021

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Lipid oxidation is the most crucial quality parameter in foods. Many methods were developed to determine the level of oxidation and antioxidant activity. This review compares the methods used to determine lipid oxidation and antioxidant capacity in foods. Lipid oxidation methods developed are based on the direct or indirect measurement of produced primary or secondary oxidation substances. Peroxide values and conjugated diene methods determine the primary oxidative products of lipid oxidation and are commonly used for plant oils and high-fat products. 2-Thiobarbituric acid-reactive substances and chromatographic methods are used to determine the secondary products of oxidation and are suitable for meat and meat-based products. The fluorometric and sensory analyses are indirect methods. The antioxidant capacity of additives is determined indirectly using the lipid oxidation methods mentioned above or directly based on the free-radical scavenging activity of the antioxidant compounds. Each lipid oxidation and antioxidant capacity methods use different approaches, and one method cannot be used for all foods. Therefore, selecting proper methods for specific foods is essential for accurately evaluating lipid oxidation or antioxidant capacity.

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Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease

Cited by 193 publications

References 53 publications

Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning

Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning

Lipid peroxidation as a hallmark of severity in COVID-19 patients

Analytical Methods for Lipid Oxidation and Antioxidant Capacity in Food Systems

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