Lipid peroxidation derived reactive aldehydes in alcoholic liver disease

Ali, Hadi; Assiri, Mohammed A.; Shearn, Colin T.; Fritz, Kristofer S.

doi:10.1016/j.cotox.2018.10.003

Cited by 18 publications

(9 citation statements)

References 145 publications

(163 reference statements)

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Section: Ald Pathogenesismentioning

confidence: 99%

“…(3) Increasing levels of circulating inflammatory cytokines (e.g., tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)) [18]; (4) Exacerbated lipid peroxidation associated with alcoholic liver injury [21]. Finally, the last player in the inflammatory and fibrogenic phenomena is catalase, a peroxisomal enzyme involved in the regulation of non-oxidative alcohol metabolism, the product by which FAEEs are responsible for alcoholic steatosis and useful as biomarkers of chronic alcohol consumption [16] (Figure 1).…”

Section: Ald Pathogenesismentioning

confidence: 99%

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Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

et al. 2023

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Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most common causes of chronic liver disease and are increasingly emerging as a global health problem. Such disorders can lead to liver damage, resulting in the release of pro-inflammatory cytokines and the activation of infiltrating immune cells. These are some of the common features of ALD progression in ASH (alcoholic steatohepatitis) and NAFLD to NASH (non-alcoholic steatohepatitis). Hepatic steatosis, followed by fibrosis, lead to a continuous progression accompanied by angiogenesis. This process creates hypoxia, which activates vascular factors, initiating pathological angiogenesis and further fibrosis. This forms a vicious cycle of ongoing damage and progression. This condition further exacerbates liver injury and may contribute to the development of comorbidities, such as metabolic syndrome as well as hepatocellular carcinoma. Increasing evidence suggests that anti-angiogenic therapy may have beneficial effects on these hepatic disorders and their exacerbation. Therefore, there is a great interest to deepen the knowledge of the molecular mechanisms of natural anti-angiogenic products that could both prevent and control liver diseases. In this review, we focus on the role of major natural anti-angiogenic compounds against steatohepatitis and determine their potential therapeutic benefits in the treatment of liver inflammation caused by an imbalanced diet.

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Section: Ald Pathogenesismentioning

confidence: 99%

Section: Ald Pathogenesismentioning

confidence: 99%

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

et al. 2023

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“…Liver is the major organ involved in the metabolic disposal of ethanol. Cytosolic alcohol dehydrogenase, microsomal ethanol-oxidizing system, and peroxisomal catalase metabolize ethanol (EtOH) to acetaldehyde [1]. e latter is a reactive metabolite that can produce injury in a variety of ways.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of BV‐7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol‐Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl₄, Induced Liver Damage in Rats

Dey¹,

Chaskar²,

Bhatt³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Excessive alcohol consumption is a worldwide threat with severe morbidity and mortality. Other than abstinence, there is still no FDA-approved drug for alcoholic liver disease (ALD). Liver is the primary site of ethanol metabolism and hence gets the most damage from excessive drinking. It triggers multiple signalling events including inflammation, leading to an array of hepatic lesions like steatosis, hepatitis, fibrosis, and cirrhosis. Similarly, when medications or xenobiotic compounds are ingested orally, the liver gets the highest exposure of those metabolites, which in turn can cause severe liver toxicity. BV-7310 is a standardized mixture of four Ayurvedic plants, namely, Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata. In different systems of traditional medicine, each of these plants has been known to have use in gastrointestinal disorders. We wanted to assess the combined effect of these plant extracts on alcohol-induced liver damage. First, we investigated the hepatoprotective activity of BV-7310 against alcohol-induced toxicity in human liver HepG2 cells. Ethanol treatment (120 mM for 48 hours) significantly showed toxicity (around 42%) in these cells, and coincubation with BV-7310 prevented ethanol-induced cell death in a dose-dependent manner. Interestingly, the formulation BV-7310 showed synergistic activity than any individual extract tested in this assay. BV-7310 also showed potent antioxidant activity in 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. Next, we induced hepatitis in Sprague–Dawley (SD) rats using repeated alcohol (40%) dosing, and carbon tetrachloride (CCl4) 24 hours before termination. Both oral doses of BV-7310 (250 and 500 mg/kg body weight) protected the alcohol-induced body weight loss and significantly improved the elevated levels of liver enzymes compared to the vehicle treated group. Thus, BV-7310 prevents alcohol-induced toxicity in both in-vitro and in-vivo models and could be beneficial for the treatment of ALD or other conditions, which may cause liver toxicity.

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“…Typically, aldehydes (e.g., formaldehyde, semialdehyde) are generated inside the human body during peroxidation of polyunsaturated fatty acids. [226] Metabolic and/or genetic disorders can increase the concentration of aldehydes in blood and breath, which may cause lung cancer, diabetes, hypertension, aging, Alzheimer's disease, Parkinson's disease, and many other diseases. [209] Thus, the presence of aldehydes above a certain threshold in exhaled breath may act as a biomarker for various diseases, including lung cancer.…”

Section: Breath Analysismentioning

confidence: 99%

Recent Advancements in Development of Wearable Gas Sensors

Bag

Lee

2021

Adv Materials Technologies

139

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In the era of the Internet of Things, wearable technologies are expected to become an indispensable part of daily life. In recent times, highly sensitive, flexible, and stretchable electronic gas sensors are gaining tremendous interest due to their applicability in wearable electronics applications. The construction of wearable gas sensors are reviewed for real‐time, highly sensitive, and selective detection of hazardous gases at room temperature (RT) that can be laminated onto a human body or integrated with body‐worn textile or other consumer products, utilizing carbon nanomaterials, conductive polymers, 2D nanostructured materials, and their composites. Sensing materials, transduction techniques, and substrates for high‐performance wearable gas sensing are discussed in detail. The critical challenges for future development of wearable gas sensors are presented. Wearable gas sensors are believed to have great potential in environmental monitoring, healthcare, public safety, security, as well as food quality monitoring.

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Lipid peroxidation derived reactive aldehydes in alcoholic liver disease

Cited by 18 publications

References 145 publications

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Hepatoprotective Activity of BV‐7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol‐Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl₄, Induced Liver Damage in Rats

Recent Advancements in Development of Wearable Gas Sensors

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Lipid peroxidation derived reactive aldehydes in alcoholic liver disease

Cited by 18 publications

References 145 publications

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Hepatoprotective Activity of BV‐7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol‐Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl4, Induced Liver Damage in Rats

Recent Advancements in Development of Wearable Gas Sensors

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Product

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Hepatoprotective Activity of BV‐7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol‐Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl₄, Induced Liver Damage in Rats