Lipid peroxidation during acute coronary syndromes and its intensification at the time of myocardial ischemia reperfusion

Iqbal, Khurshid; Rauoof, Malik A.; Mir, Mohammad Muzaffar; Tramboo, Nisar A.; Malik, Javid Ahmad; Naikoo, B; Dar, Mehboob Ali; Masoodi, Shariq Rashid; Khan, Abdul Rasheed

doi:10.1016/s0002-9149(01)02237-8

Cited by 14 publications

(11 citation statements)

References 18 publications

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“…However, a sudden restoration of oxygen supply to previously ischemic myocardium can lead to oxidative stress, with consequent oxidative injury to cell function and structure due to lipid peroxidation. Several studies have evaluated the level of MDA in patients with AMI after thrombolytic therapy [3,[10][11][12][13][14]. In all cases, there was an increase of MDA after thrombolysis, although in some studies, the increase did not reach the level of statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Markers of oxidative stress in acute myocardial infarction treated by percutaneous coronary intervention

et al. 2009

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AbstractIn the current study, we evaluated the dynamics of oxidative stress markers in patients with acute myocardial infarction (AMI) treated by primary percutaneous coronary intervention (PCI). Thirty consecutive patients with AMI with ST elevation were included. Plasma lipid peroxidation end product malondialdehyde (MDA) and total antioxidant capacity (TAC) in blood plasma were evaluated. Peripheral venous blood samples were obtained prior to reperfusion and at five time points after reperfusion. The control group consisted of 20 ischemic patients without acute coronary syndrome. TAC in the AMI group at admission was lower than in control patients (1.26 + 0.32 vs. 1.52 + 0.24 mmol/l). Within 1 h after reperfusion, in most cases, values significantly declined (1 min, 1.10 + 0.33 mmol/l; 1 h, 1.06 + 0.21 mmol/l [p= 0.03]). After 3 h, values began to increase (1.14 + 0.29 mmol/l) and returned to basal values after 3 d (1.29 + 0.24 mmol/l). MDA levels in AMI patients at admission were higher than in control patients (1.66 + 0.55 vs. 1.44 + 0.55 mmol/l) but showed a sustained decrease over the 3 h after reperfusion of the occluded artery (1 min, 1.57 + 0.37 mmol/l; 1 h, 1.50 + 0.35 μmol/l; 3 h, 1.35 + 0.59 μmol/l [p = 0.03]). Reperfusion of the occluded coronary artery by PCI in AMI lead to an immediate decrease in TAC, suggesting formation of reactive oxygen species. However, the MDA level significantly decreased after reperfusion. This may suggests less reperfusion injury after PCI.

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Section: Discussionmentioning

confidence: 99%

Markers of oxidative stress in acute myocardial infarction treated by percutaneous coronary intervention

et al. 2009

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“…Phenomena such as induction of lipid peroxidation reaction chain, [1] modification of protein structure with change of their activity, [2,3] alteration of nucleic acids [4] have been assessed in various experimental models. Moreover, the demonstration of ROS involvement in different human pathologies, including myocardial ischemia and reperfusion, [5,6] diabetes, [7] viral infections, [8] cerebral trauma, [9,10] has contributed to increase either the interest in finding possible pharmacological remedies, that should be adopted in the clinical practice for avoiding (or at least reducing) the insurgence of the aforementioned ROS-mediated cell and tissue damages, or the attention in determining different nutrients with ROS scavenging activity, that should be assumed with diet for preventing eventual ROS impact by increasing organism antioxidant defenses.…”

Section: Introductionmentioning

confidence: 99%

Cyanidin-3- O -β-glucopyranoside Protects Myocardium and Erythrocytes from Oxygen Radical-mediated Damages

Amorini

Lazzarino

Galvano

et al. 2003

Free Radical Research

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The cyanidin-3-O-beta-glucopyranoside (C-3-G) antioxidant capacity towards reactive oxygen species (ROS)-mediated damages was assessed in tissue and cells submitted to increased oxidative stress. In the isolated ischemic and reperfused rat heart, 10 or 30 degreesM C-3-G protected from both lipid peroxidation (66.7 and 94% inhibition of malondialdehyde (MDA) generation in 10 and 30 microM C-3-G-reperfused hearts, respectively, in comparison with control reperfused hearts) and energy metabolism impairment (higher ATP concentration in 10 and 30 microM C-3-G-reperfused hearts than in control reperfused hearts). These effects were associated to C-3-G permeation within myocardial cells, as indicated by results obtained in the isolated rat heart perfused for 30 min in the recirculating Langendorff mode under normoxia with 10 and 30 microM C-3-G. Protective effects were exerted, in a dose-dependent manner, by C-3-G also in 2 mM hydrogen peroxide-treated human erythrocytes. With respect to MDA formation, an apparent IC50 of 5.12 microM was calculated for C-3-G (the polyphenol resveratrol used for comparison showed an apparent IC50 of 38.43 microM). The general indications are that C-3-G (largely diffused in dietary plants and fruits, such as pigmented oranges very common in the Mediterranean diet) represents a powerful natural antioxidant with beneficial effects in case of increased oxidative stress, and at pharmacological concentrations it is able to decrease tissue damages occurring in myocardial ischemia and reperfusion.

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“…4 Some studies demonstrated an increase in lipid peroxidation products in patients with chronic coronary heart disease. [5][6][7][8] An increase in lipid peroxidation was observed in AMI, 9,10 with a In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 ± 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions.…”

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confidence: 99%

Oxidative Stress in Young Subjects With Acute Myocardial Infarction: Evaluation at the Initial Stage and After 12 Months

LoPresti

Catania

D'Amico

et al. 2007

Clin Appl Thromb Hemost

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In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.

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Lipid peroxidation during acute coronary syndromes and its intensification at the time of myocardial ischemia reperfusion

Cited by 14 publications

References 18 publications

Markers of oxidative stress in acute myocardial infarction treated by percutaneous coronary intervention

Markers of oxidative stress in acute myocardial infarction treated by percutaneous coronary intervention

Cyanidin-3- O -β-glucopyranoside Protects Myocardium and Erythrocytes from Oxygen Radical-mediated Damages

Oxidative Stress in Young Subjects With Acute Myocardial Infarction: Evaluation at the Initial Stage and After 12 Months

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