Lipid Peroxidation in Acute Respiratory Distress Syndrome and Liver Failure

Lichtenstern, Christoph; Hofer, Stefan; Möllers, Andrea; Snyder-Ramos, Steffi; Spies-Martin, Dorothee; Martin, Eike; Schmidt, Jan; Motsch, J.; Bardenheuer, Hubert J.; Weigand, Markus A.

doi:10.1016/j.jss.2009.10.028

Cited by 24 publications

(16 citation statements)

References 59 publications

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“…Due to this, oxidative stress in ARDS patients can be a secondary reason for outcome. Our study shows changes in levels of biomarkers of oxidative stress, especially on the According to recent studies, oxidative stress is an important process also in patients with hepatic malfunction, where lipid peroxidation is the main mechanism (Lichtenstern et al, 2011). Antioxidants showed greater activity in septic patients, which is in contrast with the results of our study and may be explained by different changes in levels of antioxidants for various diseases (Alonso de Vega et al, 2002).…”

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confidence: 83%

The Activity of Oxidative Stress Markers in Acute Respiratory Distress Syndrome / Oksidativa Stresa Marķieru Aktivitate Akuta Respiratora Distresa Sindroma Gadījuma

Šarkele

Ozoliņa

Sabeļņikovs

et al. 2014

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Acute respiratory distress syndrome (ARDS) is the complication of many acute conditions, which can be characterised with a non-cardiogenic lung edema and hypoxemia. The most common risk factors for developing ARDS can be grouped into direct (acute severe pneumonia, aspiration of gastric content) and indirect (sepsis, acute severe pancreatitis, massive blood component transfusion) effects (Galvin et al., 2011). The incidence of ARDS since 1990 has doubled (Sigurdsson et al., 2013), and the level of mortality can reach even 50% (Ferguson et al., 2007) in intensive care unit (ICU) patients. The treatment of these patients can be very complicated, and can include serious fluid management, feeding, extra corporal membrane oxygenation, and mechanical lung ventilation advanced techniques.Imbalance between oxidants and antioxidants may play an important role in pathogenesis of ARDS. The reactive oxygen molecules can be produced by all cells in the organism due to enzymatic and non-enzymatic processes. Lists of oxidative stress markers associated with development of many disorders are already known (Kumar et al., 2000;Bowler et al., 2003;Crimi et al., 2006), but their predictive role in ARDS is still underestimated. Reactive oxygen species initiate cellular tissue death by lipid peroxidation, and as a result also modulation of proteins and DNA.Oxidative stress related molecules, such as malondialdechyde and 4-hydroxinonenal, are important products of non-enzymatic reactions. On the other hand, protective function is provided by antioxidative molecules, for example, superoxiddismutase, glutathionperoxidase, and tocopherol.The main aim of this study was to investigate the dynamic changes of the level of oxidative stress markers in patients with acute respiratory distress syndrome. The secondary goal was to determine the relationship of the level of oxidative stress markers to the outcome in patients with acute respiratory distress syndrome.This prospective study was conducted in the ICU of Pauls Stradiòð Clinical University hospital during six months in 2013 according to the following inclusion criteria: mechanical lung ventilation 24 hours in patients over 18 years of age and acute severe pneumonia, pancreatitis, sepsis or massive blood component transfusion. The study was approved by the Ethics Committee of Rîga Stradiòð University.Patients with ARDS were monitored for seven days. The ARDS was diagnosed according to the Berlin definition (Ranieri et al., 2012)

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contrasting

confidence: 83%

The Activity of Oxidative Stress Markers in Acute Respiratory Distress Syndrome / Oksidativa Stresa Marķieru Aktivitate Akuta Respiratora Distresa Sindroma Gadījuma

Šarkele

Ozoliņa

Sabeļņikovs

et al. 2014

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Lipid peroxidation is a complex process involving the interaction of oxygen-derived free radicals with polyunsaturated acids, resulting in a variety of highly reactive electrophilic aldehydes [18]. This phenomenon occurs through an ongoing free radical chain reaction until termination occurs.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

Wang

et al. 2012

IJMS

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Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC50 ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS+, EC50 ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC50 ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS+ scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources.

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“…Reactive oxygen species are fatal to liver cells and result in cell death [13]. Significantly decreased levels of the polyunsaturated fatty acid arachidonic acid show evidence of lipid peroxidation [14]. Finally, GalN depletes the uridine triphosphate pool and thus inhibits mRNA and protein synthesis [15].…”

Section: Discussionmentioning

confidence: 99%

Metabonomic analysis of liver tissue from BALB/c mice with d-galactosamine/lipopolysaccharide-induced acute hepatic failure

Feng

Liu

et al. 2013

BMC Gastroenterol

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BackgroundCompared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic changes in acute liver failure (ALF).MethodsAfter pretreatment of liver tissue, gas chromatography coupled to time-of-flight mass spectrometry (GC/TOFMS) was used to separate and identify the liver metabolites. Partial least squares – discriminant analysis models were constructed to separate the ALF and control groups and to find those compounds whose liver levels differed significantly between the two groups.ResultsDistinct clustering was observed between the ALF and control mice. Fifty-eight endogenous metabolites were identified. Compared with the control mice, many metabolites, including sugars, amino acids, fatty acids, and organic acids, underwent significant changes in the ALF group, some of which differed from changes observed in plasma. Significant reduction of some important intermediate metabolites indicates that production of ketone bodies, the tricarboxylic acid and urea cycles, gluconeogenesis, glycolysis and pentose phosphate pathways are inhibited after GalN/LPS administration.ConclusionsGC/TOFMS can be a powerful technique to perform metabonomic studies of liver tissue. GalN/LPS treatment can severely disturb substance metabolism in the liver, with different effects on metabolites compared with those observed in the plasma.

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Lipid Peroxidation in Acute Respiratory Distress Syndrome and Liver Failure

Cited by 24 publications

References 59 publications

The Activity of Oxidative Stress Markers in Acute Respiratory Distress Syndrome / Oksidativa Stresa Marķieru Aktivitate Akuta Respiratora Distresa Sindroma Gadījuma

The Activity of Oxidative Stress Markers in Acute Respiratory Distress Syndrome / Oksidativa Stresa Marķieru Aktivitate Akuta Respiratora Distresa Sindroma Gadījuma

In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

Metabonomic analysis of liver tissue from BALB/c mice with d-galactosamine/lipopolysaccharide-induced acute hepatic failure

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