Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

“…Just as LDL can enter vessel walls, minimally modified LDL (LDL with some oxidation but not enough to be recognized by scavenger receptors) can escape back into the circulation. As a result, the sensitivity of circulating LDL to peroxidation can be a potentially valuable biomarker, suggestive of peroxidation in blood vessels [ 41 ].…”

The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice

“…Excessive oxidation products are harmful to proteins, lipids, and nucleic acids, leading to the damage to cellular structure and function (Cháfer-Pericás, 2021). Thereby, reactive oxygen species-induced lipid peroxidation could contribute to chronic diseases, such as cardiovascular disease, diabetes, cancer, and senescence (Clemente et al, 2020;Gianazza et al, 2020;Kuzgun et al, 2020). Due to the side effects of drug treatment on dyslipidemia and lipid peroxidation, finding bioactive compounds from natural products has attracted more and more attention.…”

In-Depth AGE and ALE Profiling of Human Albumin in Heart Failure: Ex Vivo Studies

“…Glyoxal can also be formed from the non-enzymatic peroxidation of polyunsaturated fatty acids, such as linoleic and linolenic acids, forming peroxide intermediates, which then degrade to yield a variety of oxidative products, including glyoxal [9]. By considering that the patients were non-diabetic and the blood glucose as well as the glycated Hb (HbA1C) content did not significantly differ between patients and control subjects, we can reasonably argue that CML adducts arise from lipid peroxidation, the occurrence of which in HF patients is well documented, as recently reviewed by Gianazza et al [16]. The involvement of GO derived from lipid peroxidation is also evidenced by the fact that the Nε-(Carboxyethyl)-L-lysine (CEL) adducts which are formed from the reaction of Lys residues with methylglyoxal (MGO), a reaction product of glycolysis but not of lipid peroxidation, were not detected.…”